Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Birgit Nelsen-Salz"'
Publikováno v:
Journal of Virology. 73:10536-10539
HBB [2-(α-hydroxybenzyl)-benzimidazole] selectively inhibits RNA synthesis of most enteroviruses. However, isolation of HBB-dependent variants is possible. Sequence analysis and characterization of recombinant viruses revealed that HBB dependence ma
Publikováno v:
Journal of Virology. 71:1697-1702
Recombinant viruses of echovirus 12 carrying mutations of a rhodanine-resistant or -dependent variant, were investigated, and five single mutations each inducing a rhodanine-resistant or -dependent phenotype were defined. Four mutations are localized
Autor:
Birgit Nelsen-Salz, Hans J. Eggers, Arne Botta, Stephan Wickert, Georg Arnold, Albert Zimmermann, J. P. Kruppenbacher
Publikováno v:
Virus Research. 41:109-122
The encephalomyocarditis (EMC) virus-induced diabetes-like syndrome in mouse inbred strains was used as a model to study the insulin-dependent diabetes mellitus (IDDM). Our investigations were performed with two EMC virus variants, PV2 and PV7. After
Publikováno v:
Virus Genes. 12:149-154
As part of a study of the molecular basis of pathogenicity of echovirus 9, the complete nucleotide sequence of the mouse-virulent echovirus 9 strain Barty was determined. Excluding the poly(A) tail, the complete RNA genome is composed of 7451 bases.
Publikováno v:
Virus Research. 39:311-319
The prototype Hill of echovirus 9, a human enterovirus, exhibits no pathogenicity for newborn mice in contrast to some other echovirus 9 strains isolated subsequently during epidemics. In this communication we report the first complete nucleotide seq
Publikováno v:
Journal of Virology. 69:5853-5858
Determination of the complete sequences of echovirus 12 and a rhodanine-resistant variant revealed seven amino acid deviations and two additional exchanges not confirmed in all clones. In rhodanine sensitivity assays with infectious cDNAs, it was sho
Publikováno v:
The Plant Journal. 2:705-711
The maize transposable element Activator (Ac) carries subterminal CpG-rich sequences which are essential for the transposition of the element. It has previously been shown that the methylation of certain sequences contained in this region can alter t
Publikováno v:
The Journal of general virology. 81(Pt 10)
Polypeptide 2C is essential for picornavirus replication. Although many data on multiple functions of this highly conserved protein are available, the mechanism of RNA binding is still obscure. In this work, protein 2C of echovirus-9 strain Barty was
Publikováno v:
The Journal of general virology. 81(Pt 4)
HBB [2-(alpha-hydroxybenzyl)-benzimidazole] and guanidine are potent inhibitors of picornavirus replication. Among other evidence, limited cross-resistance and a synergistic effect of both inhibitors suggest similar but not identical mechanisms of an
Publikováno v:
Virus research. 65(2)
Non-structural protein 2C is known to play a fundamental role in the replication of picornaviruses. Sequence analyses revealed that 2C belongs to a rapidly expanding group of proteins containing a consensus sequence for nucleotide binding (NTB). We r