Výsledky vyhledávání - "Birgit Manno"

The Dok-3/Grb2 adaptor module promotes inducible association of the lipid phosphatase SHIP with the BCR in a coreceptor-independent manner

Autor: Tim Schnyder, Thomas Oellerich, Facundo D. Batista, Michael Engelke, Jasmin Corso, Birgit Manno, Henning Urlaub, Marion Lösing, Jürgen Wienands, Konstantin Neumann

Publikováno v: European Journal of Immunology

The SH2 domain-containing inositol 5'-phosphatase (SHIP) plays a key role in preventing autoimmune phenomena by limiting antigen-mediated B cell activation. SHIP function is thought to require the dual engagement of the BCR and negative regulatory co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a32e8f597030320548d2a1f2fae5996
https://pubmed.ncbi.nlm.nih.gov/27813071

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The Dok-3/Grb2 protein signal module attenuates Lyn kinase-dependent activation of Syk kinase in B cell antigen receptor microclusters

Autor: Michael Engelke, Henning Urlaub, Birgit Manno, Hanibal Bohnenberger, Thomas Oellerich, Tim Schnyder, Björn Stork, Marion Lösing, Ingo Goldbeck, Jürgen Wienands, Facundo D. Batista

Publikováno v: Journal of Biological Chemistry

Recruitment of the growth factor receptor-bound protein 2 (Grb2) by the plasma membrane-associated adapter protein downstream of kinase 3 (Dok-3) attenuates signals transduced by the B cell antigen receptor (BCR). Here we describe molecular details o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5206f323b51d5de3a0804ca9e29e751
https://hdl.handle.net/11858/00-001M-0000-000E-ECF6-811858/00-001M-0000-000E-ECF8-4

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B cell antigen receptor-induced plasma membrane recruitment of the SH2 domain-containing inositol phosphatase is mediated by the protein tyrosine kinases Lyn and Syk

Autor: Michael Engelke, Birgit Manno, Konstantin Neumann, Jürgen Wienands, X Li

Publikováno v: Cell Communication and Signaling : CCS

Signals transduced by the B cell antigen receptor (BCR) are essential for B cell development and activation. Precise regulation of BCR signals is required to provide antigen-specific humoral immunity on one hand and tolerance of self proteins on the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dfc09ea6d2d556c225720c27b30f506
http://europepmc.org/articles/PMC4291812

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Real time monitoring of B cell antigen receptor-proximal events by fluorescence lifetime imaging

Autor: Michael Engelke, Ingo Goldbeck, Jürgen Wienands, A Stirnweiß, Roland Hartig, Werner Zuschratter, Burkhart Schraven, Birgit Manno

Publikováno v: Cell Communication and Signaling, Vol 7, Iss Suppl 1, p A72 (2009)
Cell Communication and Signaling : CCS

Many molecular events downstream of B cell antigen receptor engagement have been elucidated by different genetic and biochemical approaches. These studies revealed that a hallmark of BCR signalling is the assembly of a multiproteincomlplex comprising

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb8a78b51626cc4be4b636795666ccb

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