Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Birgit M Wollmann"'
Autor:
Robert Løvsletten Smith, Birgit M. Wollmann, Elisabet Størset, Hasan Çağın Lenk, Kevin S. O'Connell, Marianne Kringen Kristiansen, Magnus Ingelman‐Sundberg, Espen Molden
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 2, Pp n/a-n/a (2024)
Abstract Cytochrome P450 2D6 (CYP2D6) is important for metabolism of 20%–25% of all clinically used drugs. Many known genetic variants contribute to the large interindividual variability in CYP2D6 metabolism, but much is still unexplained. We recen
Externí odkaz:
https://doaj.org/article/bc583d3f16e243a881eff9ea3dbfb57a
Autor:
Birgit M. Wollmann, Elisabet Størset, Marianne Kristiansen Kringen, Espen Molden, Robert L. Smith
Publikováno v:
European Journal of Clinical Pharmacology. 79:523-531
Purpose Poor metabolizers (PMs) of the highly polymorphic enzyme CYP2D6 are usually at high risk of adverse effects during standard recommended dosing of CYP2D6-metabolized drugs. We studied if the metabolism of solanidine, a dietary compound found i
Autor:
Lennart Kyllesø, Robert Løvsletten Smith, Birgit M. Wollmann, Øystein Karlstad, Ole A. Andreassen, Espen Molden
Publikováno v:
Journal of Clinical Psychopharmacology
Purpose/Background Pharmacokinetics may be of relevance for the risk of clozapine discontinuation. We compared metabolite profiles, accounting for smoking habits, in patients switching versus maintaining clozapine treatment at therapeutic concentrati
Autor:
Birgit M. Wollmann, Robert L. Smith, Marianne Kristiansen Kringen, Magnus Ingelman‐Sundberg, Espen Molden, Elisabet Størset
Publikováno v:
British Journal of Clinical Pharmacology.
Autor:
Robert Løvsletten Smith, Birgit M. Wollmann, Lennart Kyllesø, Thu Thuy Anh Tran, Marit Tveito, Espen Molden
Publikováno v:
Journal of Clinical Psychopharmacology. 42:43-50
Valproic acid (VPA) is frequently used with clozapine (CLZ) as mood stabilizer and/or seizure prophylaxis. Valproic acid is known to reduce N-desmethylclozapine (N-DMC) but not CLZ levels. This leads to the hypothesis that VPA induces the CLZ metabol
Publikováno v:
Frederiksen, T, Smith, R L, Wollmann, B M, Areberg, J & Molden, E 2021, ' Validation of a Population Pharmacokinetic Model of Vortioxetine Using Therapeutic Drug Monitoring Data ', Clinical Pharmacokinetics, vol. 60, no. 11, pp. 1475-1486 . https://doi.org/10.1007/s40262-021-01029-7
Clinical Pharmacokinetics
Clinical Pharmacokinetics
Introduction Vortioxetine is an antidepressant primarily metabolized by the polymorphic enzyme cytochrome P450 (CYP) 2D6. A population pharmacokinetic (popPK) model of vortioxetine and its CYP2D6-dependent metabolite was recently published. Objective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c2219e990ad44f794b91b8a588049c
https://findresearcher.sdu.dk:8443/ws/files/194772021/Frederiksen_2021_Validation_of_a_population_pharmaco.pdf
https://findresearcher.sdu.dk:8443/ws/files/194772021/Frederiksen_2021_Validation_of_a_population_pharmaco.pdf
Publikováno v:
Therapeutic Drug Monitoring. 41:396-400
Drugs may potentially adsorb to blood collection tubes containing gel separators in the preanalytical phase of therapeutic drug monitoring. The aim of this study was to compare measured concentrations of 28 psychoactive drugs and 13 metabolites in sp
Autor:
Hege Christensen, Veronica Krogstad, Philip Carlo Angeles, Anders Åsberg, Ida Robertsen, Kine Eide Kvitne, Rasmus Jansson-Löfmark, Kristine Hole, Per Artursson, Rune Sandbu, Shalini Andersson, Christine Wegler, Line Kristin Johnson, Birgit M Wollmann, Jøran Hjelmesæth, Eva Skovlund, Tommy B. Andersson, Cecilia Karlsson
Publikováno v:
Clinical and Translational Science (CTS)
Clinical and Translational Science
Clinical and Translational Science, Vol 15, Iss 1, Pp 221-233 (2022)
Clinical and Translational Science
Clinical and Translational Science, Vol 15, Iss 1, Pp 221-233 (2022)
It remains uncertain whether pharmacokinetic changes following Roux‐en‐Y gastric bypass (RYGB) can be attributed to surgery‐induced gastrointestinal alterations per se and/or the subsequent weight loss. The aim was to compare short‐ and long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62809665bead3028aaa50ba4bebae32d
https://hdl.handle.net/11250/2824429
https://hdl.handle.net/11250/2824429
Autor:
Caroline Gjestad, Birgit M Wollmann, Lise Larsen Mehus, IC Olsen, Espen Molden, E Lie, SW Syversen
Publikováno v:
Clinical and Translational Science. 10:42-49
Systemic inflammation has been linked to suppressed CYP3A(4) activity. We determined 4β-hydroxycholesterol (4βOHC), an endogenous CYP3A4 metabolite, in patients with rheumatoid arthritis (RA) before and after treatment with biological disease-modif
Autor:
Lise Larsen Mehus, Elisabeth Lie, Silje Watterdal Syversen, Espen Molden, Maria Vistnes, Birgit M Wollmann
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 46(10)
Systemic inflammation has been linked to suppressed CYP3A4 activity. The aim of this study was to examine associations between levels of a broad selection of cytokines and CYP3A4 phenotype in patients with rheumatoid arthritis (RA). The study include