RASSF8-mediated transport of Echinoid via the exocyst promotes Drosophila wing elongation and epithelial ordering

Autor: David J. Barry, Maxine V. Holder, Anne Weston, Lucy M. Collinson, Eunice H Y Chan, Nicolas Tapon, Birgit L. Aerne, Yanxiang Zhou

Publikováno v: Development (Cambridge, England)
article-version (VoR) Version of Record
Development (Cambridge, England), 2021, 148 (20), ⟨10.1242/dev.199731⟩

Cell-cell junctions are dynamic structures that maintain cell cohesion and shape in epithelial tissues. During development, junctions undergo extensive rearrangements to drive the epithelial remodelling required for morphogenesis. This is particularl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e462571e67cfc2ab7584f6994ee342d
http://europepmc.org/articles/PMC8572004

Regulation of nuclear factor κB (NF-κB) transcriptional activity via p65 acetylation by the chaperonin containing TCP1 (CCT).

Autor: Nadja Pejanovic, Karin Hochrainer, Tao Liu, Birgit L Aerne, Miguel P Soares, Josef Anrather

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e42020 (2012)

The NF-κB family member p65 is central to inflammation and immunity. The purpose of this study was to identify and characterize evolutionary conserved genes modulating p65 transcriptional activity. Using an RNAi screening approach, we identified cha

Externí odkaz: https://doaj.org/article/cfe851ef7b9a4d9680149cbbf39e5cf9

Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division

Autor: Simon Hauri, Maxine V. Holder, Birgit L. Aerne, Matthias Gstaiger, Jennifer J Banerjee, Nicolas Tapon

Publikováno v: eLife, 6
eLife, Vol 6 (2017)
eLife

Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99d714ccb76b1f0ea8ad0050b5c80c0
https://hdl.handle.net/20.500.11850/191249

Drosophila ASPP Regulates C-Terminal Src Kinase Activity

Autor: Birgit L. Aerne, Nicolas Tapon, Paul F. Langton, Julien Colombani

Publikováno v: Developmental Cell. 13(6):773-782

Src-family kinases (SFKs) control a variety of biological processes, from cell proliferation and differentiation to cytoskeletal rearrangements. Abnormal activation of SFKs has been implicated in a wide variety of cancers and is associated with metas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c51899bd1d090afc19b44aaa8f6852

Hippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4

Autor: Ieva Gailite, David Sims, Nicolas Tapon, Birgit L. Aerne

Publikováno v: PLoS ONE
PLoS ONE, Vol 10, Iss 6, p e0131113 (2015)

Signalling through the Hippo (Hpo) pathway involves a kinase cascade, which leads to the phosphorylation and inactivation of the pro-growth transcriptional co-activator Yorkie (Yki). Despite the identification of a large number of pathway members and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffea58beadf3825271e010f6af0d7a08
https://pubmed.ncbi.nlm.nih.gov/26125558