Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Birgit Kegel"'
Autor:
Heike A, Behrensdorf-Nicol, Emina, Wild, Ursula, Bonifas, Jolanta, Klimek, Kay-Martin, Hanschmann, Beate, Krämer, Birgit, Kegel
Publikováno v:
Toxicology in Vitro. 53:80-88
Botulinum neurotoxins (BoNTs) inhibit the release of the neurotransmitter acetylcholine from motor neurons, resulting in highly effective muscle relaxation. In clinical and aesthetic medicine, serotype BoNT/A, which is most potent for humans, is wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a938c17955ad741ba4376cd3bceafb99
https://doi.org/10.1016/j.tiv.2018.07.008
https://doi.org/10.1016/j.tiv.2018.07.008
Autor:
Ursula Bonifas, Birgit Kegel, Lars Töllner, Brigitte G. Dorner, Christine Hohenadl, Beate Krämer, Heike A. Behrensdorf-Nicol, Kay-Martin Hanschmann, Jolanta Klimek
Publikováno v:
Biologicals : journal of the International Association of Biological Standardization. 67
The muscle-relaxing effects of the botulinum neurotoxin (BoNT) serotypes A and B are widely used in clinical and aesthetic medicine. The standard method for measuring the biological activity of pharmaceutical BoNT products is a mouse bioassay. In lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de1313fced17cdab044ae8f332a7ed1
https://pubmed.ncbi.nlm.nih.gov/32739117
https://pubmed.ncbi.nlm.nih.gov/32739117
Autor:
Beate Krämer, Birgit Kegel, Heike A. Behrensdorf-Nicol, Jolanta Klimek, Ursula Bonifas, Kay-Martin Hanschmann
Publikováno v:
Toxicon. 190:S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24775db23f0be933701d30ea98f38424
https://doi.org/10.1016/j.toxicon.2020.11.354
https://doi.org/10.1016/j.toxicon.2020.11.354
Autor:
Heidemarie Ratsch, Gerhard Stiens, Andrew Pickett, Dirk Dressler, Dorothea Sesardic, Manfred Liebsch, Irmela Ruhdel, Birgit Kegel, Andreas Luch, Peter D. Thornton, Gerd Bicker, Martin Vey, Catherine Milne, Sarah Adler, Hans Bigalke, Joan Fitzgerald, Heide Heuschen, Frank Gessler, Christopher Bishop, René Thürmer, Martin L. Stephens, Jörg Blümel, Horst Spielmann, Barbara Grune
Publikováno v:
Alternatives to Laboratory Animals. 38:315-330
An Expert Meeting on The Current Scientific and Legal Status of Alternative Methods to the LD50 Test for Botulinum Neurotoxin (BoNT) Potency Testing was organised by the Centre for Documentation and Evaluation of Alternatives to Animal Experiments (Z
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ef209315b1946b279a0fca5c256edca
https://doi.org/10.1177/026119291003800401
https://doi.org/10.1177/026119291003800401
Autor:
Heike A. Behrensdorf-Nicol, Birgit Kegel, Ursula Bonifas, K. Weißer, K. Silberbach, Beate Krämer
Publikováno v:
Toxicology in Vitro. 24:988-994
Assays for the detection of tetanus neurotoxin (TeNT) are relevant for research applications as well as for the safety testing of tetanus vaccines. So far, these assays are usually performed as toxicity tests in guinea pigs or mice. The alternative m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46e90eb6ebc9e2ec104c2b7e700437b
https://doi.org/10.1016/j.tiv.2009.12.018
https://doi.org/10.1016/j.tiv.2009.12.018
Autor:
Ursula Bonifas, Beate Krämer, K. Silberbach, Birgit Kegel, Heike A. Behrensdorf-Nicol, Jolanta Klimek, K. Weißer
Publikováno v:
Toxicology in Vitro. 21:1641-1649
Tetanus neurotoxin (TeNT1) is a bacterial protease which specifically cleaves the vesicle protein synaptobrevin-2 (vesicle associated membrane protein-2, VAMP-2). This proteolytic feature of the toxin has been used to develop a sensitive endopeptidas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21417cd1a40629aa4272e5e98b70a54a
https://doi.org/10.1016/j.tiv.2007.06.015
https://doi.org/10.1016/j.tiv.2007.06.015
Autor:
Norbert Braun, Eltahmash Israr, Petra Heine, Herbert Zimmermann, Birgit Kegel, Petra Vollmayer, Marco Koch, Jörg Servos
Publikováno v:
Journal of Neurochemistry. 78:1019-1028
The physiological action of extracellular ATP and other nucleotides in the nervous system is controlled by surface-located enzymes (ecto-nucleotidases) of which several families with partially overlapping substrate specificities exist. In order to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ede3ef80f548045229858c8216183757
https://doi.org/10.1046/j.1471-4159.2001.00480.x
https://doi.org/10.1046/j.1471-4159.2001.00480.x
Autor:
Ursula Bonifas, Heike A. Behrensdorf-Nicol, Jolanta Klimek, Birgit Kegel, Beate Krämer, Emina Wild, Jan-Hendrik Trösemeier
Publikováno v:
Toxicon. 123:S84
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a1437a0ee0453323960c200c7145ac9
https://doi.org/10.1016/j.toxicon.2016.11.232
https://doi.org/10.1016/j.toxicon.2016.11.232
Autor:
Birgit Kegel, Ursula Bonifas, K. Silberbach, Heike A. Behrensdorf-Nicol, K. Weißer, Jolanta Klimek, Beate Krämer
Publikováno v:
Vaccine. 26(31)
The light chain of tetanus neurotoxin (TeNT) is a zinc-dependent metalloprotease which specifically cleaves the synaptic vesicle protein synaptobrevin. This crucial mechanism of tetanus toxicity leads to a blockade of inhibitory neurotransmitter rele
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f9dd0bc1b55f4d1e98f38c52fae7d5
https://pubmed.ncbi.nlm.nih.gov/18554757
https://pubmed.ncbi.nlm.nih.gov/18554757