Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Birgit I, Gaiser"'
Autor:
Wanisa Salaemae, Andrew P. Thompson, Birgit I. Gaiser, Kwang Jun Lee, Michael T. Huxley, Christopher J. Sumby, Steven W. Polyak, Andrew D. Abell, John B. Bruning, Kate L. Wegener
We previously reported potent ligands and inhibitors ofMycobacterium tuberculosisdethiobiotin synthetase (MtDTBS), a promising target for antituberculosis drug development (Schumannet al.,ACS Chem Biol. 2021, 16, 2339-2347); here the unconventional o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bd3bb7628f80537dee2c1e04bf286f8
https://doi.org/10.1101/2023.03.26.531482
https://doi.org/10.1101/2023.03.26.531482
Autor:
Jordan L. Pederick, Birgit I Gaiser, Nicholas C Schumann, Kate L. Wegener, Kwangjun Lee, James Hodgkinson-Bean, Steven W. Polyak, Thomas D. Avery, Grant W. Booker, John B. Bruning, Andrew D. Abell, Wanisa Salaemae, Andrew P. Thompson
Publikováno v:
ACS Chemical Biology. 16:2339-2347
Mycobacterium tuberculosis dethiobiotin synthase (MtDTBS) is a crucial enzyme involved in the biosynthesis of biotin in the causative agent of tuberculosis, M. tuberculosis. Here, we report a binder of MtDTBS, cyclopentylacetic acid 2 (KD = 3.4 ± 0.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ac2bc6435643604f3c068bed34da81f
https://doi.org/10.1021/acschembio.1c00491
https://doi.org/10.1021/acschembio.1c00491
Autor:
Nicholas C, Schumann, Kwang Jun, Lee, Andrew P, Thompson, Wanisa, Salaemae, Jordan L, Pederick, Thomas, Avery, Birgit I, Gaiser, James, Hodgkinson-Bean, Grant W, Booker, Steven W, Polyak, John B, Bruning, Kate L, Wegener, Andrew D, Abell
Publikováno v:
ACS chemical biology. 16(11)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a67d54aea5164bd70befc0f5c2bc214
https://pubmed.ncbi.nlm.nih.gov/34533923
https://pubmed.ncbi.nlm.nih.gov/34533923
Autor:
Kira Røpke Jørgensen, David E. Gloriam, Jesper Mosolff Mathiesen, Mikael Frykman, Daniel Sejer Pedersen, Emil Märcher-Rørsted, Henrik Johansson, Tomasz M. Wróbel, Mia Danielsen, Hans Bräuner-Osborne, Birgit I. Gaiser
Publikováno v:
Journal of Medicinal Chemistry. 62:7806-7839
Herein, we report the development of bitopic ligands aimed at targeting the orthosteric binding site (OBS) and a metastable binding site (MBS) within the same receptor unit. Previous molecular dynamics studies on ligand binding to the β2-adrenergic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f266c9b44be06ae8c41471ac2e4cba3
https://doi.org/10.1021/acs.jmedchem.9b00595
https://doi.org/10.1021/acs.jmedchem.9b00595
Autor:
Birgit I, Gaiser, Mia, Danielsen, Emil, Marcher-Rørsted, Kira, Røpke Jørgensen, Tomasz M, Wróbel, Mikael, Frykman, Henrik, Johansson, Hans, Bräuner-Osborne, David E, Gloriam, Jesper Mosolff, Mathiesen, Daniel, Sejer Pedersen
Publikováno v:
Journal of medicinal chemistry. 62(17)
Herein, we report the development of bitopic ligands aimed at targeting the orthosteric binding site (OBS) and a metastable binding site (MBS) within the same receptor unit. Previous molecular dynamics studies on ligand binding to the β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6e99f45875f5b20c131181f4a364116d
https://pubmed.ncbi.nlm.nih.gov/31298548
https://pubmed.ncbi.nlm.nih.gov/31298548
Publikováno v:
Journal of medicinal chemistry. 60(10)
G protein-coupled receptors (GPCRs) belong to a large superfamily of membrane receptors mediating a variety of physiological functions. As such they are attractive targets for drug therapy. However, it remains a challenge to develop subtype selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce91cb67ec6357416058cbceae50383
https://pubmed.ncbi.nlm.nih.gov/28140580
https://pubmed.ncbi.nlm.nih.gov/28140580