Zobrazeno 1 - 10
of 177
pro vyhledávání: '"Birgit Hutter‐Paier"'
Autor:
Joshua Adekunle Babalola, Anika Stracke, Tina Loeffler, Irene Schilcher, Spyridon Sideromenos, Stefanie Flunkert, Joerg Neddens, Ake Lignell, Manuela Prokesch, Ute Panzenboeck, Herbert Strobl, Jelena Tadic, Gerd Leitinger, Achim Lass, Birgit Hutter-Paier, Gerald Hoefler
Publikováno v:
Molecular Metabolism, Vol 86, Iss , Pp 101972- (2024)
Externí odkaz:
https://doaj.org/article/d463c6ae0e50498bb0f6926bfae42908
Autor:
Joshua Adekunle Babalola, Anika Stracke, Tina Loeffler, Irene Schilcher, Spyridon Sideromenos, Stefanie Flunkert, Joerg Neddens, Ake Lignell, Manuela Prokesch, Ute Pazenboeck, Herbert Strobl, Jelena Tadic, Gerd Leitinger, Achim Lass, Birgit Hutter-Paier, Gerald Hoefler
Publikováno v:
Molecular Metabolism, Vol 85, Iss , Pp 101959- (2024)
Objectives: Aggregation and misfolding of amyloid beta (Aβ) and tau proteins, suggested to arise from post-translational modification processes, are thought to be the main cause of Alzheimer's disease (AD). Additionally, a plethora of evidence exist
Externí odkaz:
https://doaj.org/article/adc5cdc60dae4aeea2d8de4c6bfa0ca8
Autor:
Shirin Sharghi, Stefanie Flunkert, Magdalena Daurer, Roland Rabl, Boris Philippe Chagnaud, Marcello Leopoldo, Enza Lacivita, Birgit Hutter-Paier, Manuela Prokesch
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionAutism spectrum disorder (ASD) is a persistent neurodevelopmental condition characterized by two core behavioral symptoms: impaired social communication and interaction, as well as stereotypic, repetitive behavior. No distinct cause of AS
Externí odkaz:
https://doaj.org/article/bf00381a84fc4ffaa83f71f23204e7fe
Autor:
Thomas Filip, Severin Mairinger, Joerg Neddens, Michael Sauberer, Stefanie Flunkert, Johann Stanek, Thomas Wanek, Nobuyuki Okamura, Oliver Langer, Birgit Hutter-Paier, Claudia Kuntner
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-13 (2021)
Abstract Background To better understand the etiology and pathomechanisms of Alzheimer’s disease, several transgenic animal models that overexpress human tau or human amyloid-beta (Aβ) have been developed. In the present study, we generated a nove
Externí odkaz:
https://doaj.org/article/f7befd60ea1646b98674434c48abf123
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Externí odkaz:
https://doaj.org/article/222ace6f94674711b2e80d64198f6ca8
Autor:
Helen Crehan, Bin Liu, Martin Kleinschmidt, Jens-Ulrich Rahfeld, Kevin X. Le, Barbara J. Caldarone, Jeffrey L. Frost, Thore Hettmann, Birgit Hutter-Paier, Brian O’Nuallain, Mi-Ae Park, Marcelo F. DiCarli, Inge Lues, Stephan Schilling, Cynthia A. Lemere
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2020)
Abstract Background Pyroglutamate-3 Aβ (pGlu-3 Aβ) is an N-terminally truncated and post-translationally modified Aβ species found in Alzheimer’s disease (AD) brain. Its increased peptide aggregation propensity and toxicity make it an attractive
Externí odkaz:
https://doaj.org/article/a0a62adb0fd742e6bf4a5334e028d25a
Autor:
Agnes Molnar-Kasza, Barbara Hinteregger, Joerg Neddens, Roland Rabl, Stefanie Flunkert, Birgit Hutter-Paier
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2021)
Amyotrophic lateral sclerosis (ALS) still depicts an incurable and devastating disease. Drug development efforts are mostly based on superoxide dismutase 1 gene (SOD1)-G93A mice that present a very strong and early phenotype, allowing only a short ti
Externí odkaz:
https://doaj.org/article/6cfbeb8bdd8e4c9fa1a428a29d137ea9
Autor:
Gernot F. Grabner, Nermeen Fawzy, Maria A. Pribasnig, Markus Trieb, Ulrike Taschler, Michael Holzer, Martina Schweiger, Heimo Wolinski, Dagmar Kolb, Angela Horvath, Rolf Breinbauer, Thomas Rülicke, Roland Rabl, Achim Lass, Vanessa Stadlbauer, Birgit Hutter-Paier, Rudolf E. Stauber, Peter Fickert, Rudolf Zechner, Gunther Marsche, Thomas O. Eichmann, Robert Zimmermann
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 5, Pp 1020-1031 (2019)
Bis(monoacylglycerol)phosphate (BMP) is a phospholipid that is crucial for lipid degradation and sorting in acidic organelles. Genetic and drug-induced lysosomal storage disorders (LSDs) are associated with increased BMP concentrations in tissues and
Externí odkaz:
https://doaj.org/article/6811fbb03319497cbbdc699b457cff47
Autor:
Estibaliz Etxeberria-Rekalde, Saioa Alzola-Aldamizetxebarria, Stefanie Flunkert, Isabella Hable, Magdalena Daurer, Joerg Neddens, Birgit Hutter-Paier
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2021)
Huntington’s disease (HD) is caused by an expansion of CAG triplets in the huntingtin gene, leading to severe neuropathological changes that result in a devasting and lethal phenotype. Neurodegeneration in HD begins in the striatum and spreads to o
Externí odkaz:
https://doaj.org/article/6c00daedc56e4f30a6118a1c306a2f1f
Autor:
Joerg Neddens, Magdalena Daurer, Tina Loeffler, Saioa Alzola Aldamizetxebarria, Stefanie Flunkert, Birgit Hutter-Paier
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Excessive tau phosphorylation is the hallmark of tauopathies. Today’s research thus focusses on the development of drugs targeting this pathological feature. To test new drugs in preclinical studies, animal models are needed that properly mimic thi
Externí odkaz:
https://doaj.org/article/df5722407bdb4230818fc8a4c7743ad7