Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Birgit Heltweg"'
Autor:
Antonio Bedalov, Julian A. Simon, Yansong Gu, Ronald A. DePinho, Ramya Kollipara, Sondra Goehle, Hongzhe Li, Jeff Posakony, Aaron D. Schuler, Tonibelle Gatbonton, Birgit Heltweg
Supplementary Figure 3 from Antitumor Activity of a Small-Molecule Inhibitor of Human Silent Information Regulator 2 Enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d7ff873e40d7420e02a95c0a51e5f6
https://doi.org/10.1158/0008-5472.22366713.v1
https://doi.org/10.1158/0008-5472.22366713.v1
Autor:
Antonio Bedalov, Julian A. Simon, Yansong Gu, Ronald A. DePinho, Ramya Kollipara, Sondra Goehle, Hongzhe Li, Jeff Posakony, Aaron D. Schuler, Tonibelle Gatbonton, Birgit Heltweg
Supplementary Figure 6 from Antitumor Activity of a Small-Molecule Inhibitor of Human Silent Information Regulator 2 Enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a154bf39326cc085b428165f00e2e1af
https://doi.org/10.1158/0008-5472.22366704.v1
https://doi.org/10.1158/0008-5472.22366704.v1
Autor:
Antonio Bedalov, Julian A. Simon, Yansong Gu, Ronald A. DePinho, Ramya Kollipara, Sondra Goehle, Hongzhe Li, Jeff Posakony, Aaron D. Schuler, Tonibelle Gatbonton, Birgit Heltweg
Supplementary Figure 1 from Antitumor Activity of a Small-Molecule Inhibitor of Human Silent Information Regulator 2 Enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e49c2017451866b1f69b4625ce2bf98
https://doi.org/10.1158/0008-5472.22366719
https://doi.org/10.1158/0008-5472.22366719
Autor:
Antonio Bedalov, Julian A. Simon, Yansong Gu, Ronald A. DePinho, Ramya Kollipara, Sondra Goehle, Hongzhe Li, Jeff Posakony, Aaron D. Schuler, Tonibelle Gatbonton, Birgit Heltweg
Supplementary Figure 7 from Antitumor Activity of a Small-Molecule Inhibitor of Human Silent Information Regulator 2 Enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64f6bd4fed6dd7e7c1300d0da13629f
https://doi.org/10.1158/0008-5472.22366701
https://doi.org/10.1158/0008-5472.22366701
Autor:
Antonio Bedalov, Julian A. Simon, Yansong Gu, Ronald A. DePinho, Ramya Kollipara, Sondra Goehle, Hongzhe Li, Jeff Posakony, Aaron D. Schuler, Tonibelle Gatbonton, Birgit Heltweg
Supplementary Figure 2 from Antitumor Activity of a Small-Molecule Inhibitor of Human Silent Information Regulator 2 Enzymes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::660f4323fec4cf9369b7d63b738660d7
https://doi.org/10.1158/0008-5472.22366716
https://doi.org/10.1158/0008-5472.22366716
Autor:
Antonio Bedalov, Julian A. Simon, Yansong Gu, Ronald A. DePinho, Ramya Kollipara, Sondra Goehle, Hongzhe Li, Jeff Posakony, Aaron D. Schuler, Tonibelle Gatbonton, Birgit Heltweg
SIRT1 and other NAD-dependent deacetylases have been implicated in control of cellular responses to stress and in tumorigenesis through deacetylation of important regulatory proteins, including p53 and the BCL6 oncoprotein. Hereby, we describe the id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7664d9d521942265647d12bd0d29621
https://doi.org/10.1158/0008-5472.c.6495255.v1
https://doi.org/10.1158/0008-5472.c.6495255.v1
Autor:
Ramya Kollipara, Birgit Heltweg, Yansong Gu, S Goehle, Julian A. Simon, Ronald A. DePinho, Antonio Bedalov, Aaron D. Schuler, Hongzhe Li, Jeff Posakony, Tonibelle Gatbonton
Publikováno v:
Cancer Research. 66:4368-4377
SIRT1 and other NAD-dependent deacetylases have been implicated in control of cellular responses to stress and in tumorigenesis through deacetylation of important regulatory proteins, including p53 and the BCL6 oncoprotein. Hereby, we describe the id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c1bc8dedbc1c36d87c4133896c6ec6
https://doi.org/10.1158/0008-5472.can-05-3617
https://doi.org/10.1158/0008-5472.can-05-3617
Autor:
Brett Marshall, Carsten Brauch, Manfred Jung, Eric Verdin, Minoru Yoshida, Birgit Heltweg, Norikazu Nishino, Franck Dequiedt
Publikováno v:
Journal of Medicinal Chemistry. 47:5235-5243
To probe the steric requirements for deacylation, we synthesized lysine-derived small molecule substrates and examined structure-reactivity relationships with various histone deacetylases. Rat liver, human HeLa, and human recombinant class I and II h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d69331a6328b3644d7dcf22fc8fe5f6e
https://doi.org/10.1021/jm0497592
https://doi.org/10.1021/jm0497592
Publikováno v:
Analytical Biochemistry. 319:42-48
Histone deacetylases (HDACs) are involved in the regulation of transcription and their inhibitors are a promising class of new anticancer drugs. We have previously reported Boc(Ac)Lys-AMC, also termed MAL, as a fluorescent substrate for HDACs. Now we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbecc46da882c187f7f99950be105af4
https://doi.org/10.1016/s0003-2697(03)00276-8
https://doi.org/10.1016/s0003-2697(03)00276-8
Autor:
Birgit Heltweg, Manfred Jung
Publikováno v:
Analytical Biochemistry. 302:175-183
Recent years have brought an enormous increase in knowledge concerning the involvement of histone deacetylase (HDAC) in gene regulation and the potential use of its inhibitors in transcription therapy. This also stimulates research toward new methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a6421703b49234223ea4679c825e8d5
https://doi.org/10.1006/abio.2001.5542
https://doi.org/10.1006/abio.2001.5542