Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Birgit Fichtlscherer"'
Autor:
Birgit Fichtlscherer, Alexander Muelsch, Cornel Badorff, Andreas M. Zeiher, Stefanie Dimmeler
Publikováno v:
Nitric Oxide. 6:305-312
Nitric oxide (NO) regulates multiple biological processes. To use NO as a potential therapeutic substance, a more selective modulation of individual NO targets is desirable. Here, we tested whether peptide conjugation of the dinitrosyl-iron complex (
Publikováno v:
Free Radical Biology and Medicine. 27:636-646
The nitrogen monoxide radical (NO ) forms paramagnetic mono- and dinitrosyl–iron complexes in biologic tissues. To establish a noninvasive technique for in vivo NO imaging, we evaluated the suitability of these complexes as magnetic resonance (MR)
Autor:
Lothar Rossig, Stefanie Dimmeler, Alexander Mülsch, Judith Haendeler, Andreas M. Zeiher, Birgit Fichtlscherer, Kristin Breitschopf
Publikováno v:
Journal of Biological Chemistry. 274:6823-6826
In cultured human endothelial cells, physiological levels of NO prevent apoptosis and interfere with the activation of the caspase cascade. In vitro data have demonstrated that NO inhibits the activity of caspase-3 by S-nitrosation of the enzyme. Her
Autor:
Karl-Friedrich Beck, Birgit Fichtlscherer, Andrea Huwiler, Oliver Wingerter, Ralf P. Brandes, Miriam Pleskova, Meik Helmut Behrens, Alexander Mülsch, Josef Pfeilschifter
Publikováno v:
GBM Annual Spring meeting Mosbach 2006. 2006
Autor:
Birgit Fichtlscherer, Ralf P. Brandes, Andrea Huwiler, Meik Helmut Behrens, Alexander Mülsch, Miriam Pleskova, Oliver Wingerter, Josef Pfeilschifter, Karl-Friedrich Beck
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 20(1)
Glomerular mesangial cells can produce high amounts of nitric oxide (NO) and reactive oxygen species (ROS). Here we analyzed the impact of NO on the ROS-generating system, particularly on the NADPH oxidase Nox1. Nox1 mRNA and protein levels were mark
Autor:
Birgit Fichtlscherer, Beate Fisslthaler, Bruce E. Kemp, Christian Schulz, Rudi Busse, Ingrid Fleming
Publikováno v:
Scopus-Elsevier
SummaryLittle is known about the signaling cascades that eventually regulate the activity of the endothelial nitric oxide synthase (eNOS) in platelets. Here, we investigated the effects of insulin on the phosphorylation and activation of eNOS in wash
Autor:
Andrei L. Kleschyov, Thomas Münzel, Birgit Fichtlscherer, Alexander Mülsch, Eberhard Schulz, Andreas Daiber, Karsten Sydow, Yale Huang, Matthias Oelze, Hanke Mollnau
Publikováno v:
Circulation Research. 93
Nitroglycerin (glyceryl trinitrate, GTN) relaxes blood vessels primarily via activation of the soluble guanylyl cyclase (sGC)/cGMP/cGMP-dependent protein kinase (cGK-I) pathway. Although the precise mechanism of sGC activation by GTN in the vascular
Autor:
Karin Kohlstedt, Alexander Mülsch, Rudi Busse, Ingrid Fleming, Birgit Fichtlscherer, Helena Lenasi
Publikováno v:
Cardiovascular research. 59(4)
Objective: The Ca2+ antagonist amlodipine increases the generation of nitric oxide (NO) from native and cultured endothelial cells. The aim of this investigation was to determine whether or not the activation of the endothelial NO synthase (eNOS) by
Autor:
Kirk U. Knowlton, Alexander Muelsch, Birgit Fichtlscherer, Cornel Badorff, Stefanie Dimmeler, Robert E. Rhoads, Andreas M. Zeiher
Publikováno v:
Circulation. 102(18)
Background —Infection with enteroviruses like coxsackievirus B3 (CVB3) as well as genetic dystrophin deficiency can cause dilated cardiomyopathy. We recently identified cleavage and functional impairment of dystrophin by the viral protease 2A durin
Autor:
Birgit Fichtlscherer, Alexander Mülsch
Publikováno v:
Radiology. 216(1)
To assess the influence of several nitrosyl-iron complexes on proton nuclear spin relaxation rates to establish a magnetic resonance (MR) imaging technique for nitric oxide.The influence of aqueous phantom solutions of nitrosyl-iron complexes on prot