Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism

Autor: Christopher R. Wellaway, Ian R. Baldwin, Paul Bamborough, Daniel Barker, Michelle A. Bartholomew, Chun-wa Chung, Birgit Dümpelfeld, John P. Evans, Neal J. Fazakerley, Paul Homes, Steven P. Keeling, Xiao Q. Lewell, Finlay W. McNab, Joanne Morley, Deborah Needham, Margarete Neu, Antoon J. M. van Oosterhout, Anshu Pal, Friedrich B. M. Reinhard, Francesco Rianjongdee, Craig M. Robertson, Paul Rowland, Rishi R. Shah, Emma B. Sherriff, Lisa A. Sloan, Simon Teague, Daniel A. Thomas, Natalie Wellaway, Justyna Wojno-Picon, James M. Woolven, Diane M. Coe

Publikováno v: Journal of Medicinal Chemistry. 65:633-664

The Janus family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) play an essential role in the receptor signaling of cytokines that have been implicated in the pathogenesis of severe asthma, and there is emerging interest in the development of small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25612a371cd9b4befcdd69bdbd64fbaa
https://doi.org/10.1021/acs.jmedchem.1c01765

Determination of kinase inhibitor potencies in cell extracts by competition binding assays and isobaric mass tags

Autor: Carsten, Hopf, Dirk, Eberhard, Markus, Boesche, Sonja, Bastuck, Birgit, Dümpelfeld, Marcus, Bantscheff

Publikováno v: Methods in molecular biology (Clifton, N.J.). 803

Chemical proteomics offers a unique approach for target identification of small molecule inhibitors directly from cell extracts, thus enabling characterization of target proteins under close to physiological conditions. Here, we describe a competitio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3344fd6f61a86877b50728be6e5ee913
https://pubmed.ncbi.nlm.nih.gov/22065223

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

Autor: Isabelle Becher, Valerie Reader, Giovanna Bergamini, Gavain Sweetman, Carola Huthmacher, Nigel Ramsden, Katja Strunk, Dirk Eberhard, Markus Boesche, Antje Dittmann, Marcus Bantscheff, Mikhail M. Savitski, Ulrich Kruse, Daniel Poeckel, Birgit Dümpelfeld, Gitte Neubauer, Judith Schlegl, Anne-Marie Michon, Gerard Drewes, Paola Grandi, Toby Mathieson, Carsten Hopf, Yann Abraham, Manja Delling

Publikováno v: Nature biotechnology. 29(3)

The development of selective histone deacetylase (HDAC) inhibitors with anti-cancer and anti-inflammatory properties remains challenging in large part owing to the difficulty of probing the interaction of small molecules with megadalton protein compl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858112a78ab434e3f673b402df393db3
https://pubmed.ncbi.nlm.nih.gov/21390028

Proteome survey reveals modularity of the yeast cell machinery

Autor: Paola Grandi, Georg Casari, Roland Krause, Marie-Anne Heurtier, Lars Juhl Jensen, Anne-Marie Michon, Gerard Drewes, Martina Marzioch, Angela Edelmann, Andreas Bauer, Christian Hoefert, Christina Rau, Verena Hoffman, Tatjana Rudi, Marita Remor, Giulio Superti-Furga, Karin Klein, Bernhard Kuster, Tewis Bouwmeester, Patrick Aloy, Robert B. Russell, Manuela Hudak, Sonja Bastuck, Birgit Dümpelfeld, Jens Rick, Markus Schirle, Markus Boesche, Peer Bork, Sean D. Hooper, Malgorzata Schelder, Gitte Neubauer, Anne-Claude Gavin

Publikováno v: Nature, Vol. 440, No 7084 (2006) pp. 631-636

Protein complexes are key molecular entities that integrate multiple gene products to perform cellular functions. Here we report the first genome-wide screen for complexes in an organism, budding yeast, using affinity purification and mass spectromet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d8009f07f8203f6ed2e3505bdf3e5b
https://archive-ouverte.unige.ch/unige:156899

Biotransformation novel advances – 2021 year in review.

Autor: Khojasteh, S. Cyrus¹ (AUTHOR), Argikar, Upendra A.² (AUTHOR), Cho, Sungjoon¹ (AUTHOR), Crouch, Rachel³ (AUTHOR), Heck, Carley J. S.⁴ (AUTHOR), Johnson, Kevin M.¹ (AUTHOR), Kalgutkar, Amit S.⁵ (AUTHOR), King, Lloyd⁶ (AUTHOR), Maw, Hlaing⁷ (AUTHOR), Seneviratne, Herana Kamal⁸ (AUTHOR), Wang, Shuai¹ (AUTHOR), Wei, Cong⁹ (AUTHOR), Zhang, Donglu¹ (AUTHOR), Jackson, Klarissa D.¹⁰ (AUTHOR), Kramlinger, Valerie M. (AUTHOR), Dalvie, Deepak (AUTHOR), O'Neill, James (AUTHOR), Su, Dian (AUTHOR), Teitelbaum, Aaron M. (AUTHOR), Totah, Rheem A. (AUTHOR)

Publikováno v: Drug Metabolism Reviews. Aug2022, Vol. 54 Issue 3, p207-245. 39p.