Structural elements in the flexible tail of the co-chaperone p23 coordinate client binding and progression of the Hsp90 chaperone cycle

Autor: Maximilian M. Biebl, Abraham Lopez, Alexandra Rehn, Lee Freiburger, Jannis Lawatscheck, Birgit Blank, Michael Sattler, Johannes Buchner

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

p23 is a co-chaperone of Hsp90 but its mode of action is mechanistically not well understood. Here, the authors combine in vitro and yeast in vivo assays, biochemical measurements and NMR experiments to characterize p23 and identify two conserved hel

Externí odkaz: https://doaj.org/article/a9b045045e0840e9b855e22c23e4ac09

Author Correction: A methylated lysine is a switch point for conformational communication in the chaperone Hsp90

Autor: Alexandra Rehn, Jannis Lawatscheck, Marie-Lena Jokisch, Sophie L. Mader, Qi Luo, Franziska Tippel, Birgit Blank, Klaus Richter, Kathrin Lang, Ville R. I. Kaila, Johannes Buchner

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Externí odkaz: https://doaj.org/article/9000f64049f1435abef4e720c2f80539

Fam20C regulates protein secretion by Cab45 phosphorylation

Autor: Gisela Beck, Martin Steger, Tobias Karl Heinz Hecht, Vincent S. Tagliabracci, Matthias Mann, Victor Lopez, Birgit Blank, Julia von Blume, Bulat Ramazanov

Publikováno v: The Journal of Cell Biology

The TGN is a central compartment for protein sorting and secretion. Hecht et al. demonstrate that Cab45, a Ca2+-dependent sorting protein in the TGN, is phosphorylated by the Golgi kinase Fam20C. Phosphorylation of Cab45 decreases its TGN retention a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ec805879b565771deb96e3f8b59b4a
http://europepmc.org/articles/PMC7265331

Nucleobindin-1 regulates ECM degradation by promoting intra-Golgi trafficking of MMPs

Autor: Tobias Karl Heinz Hecht, Renate Gautsch, Ismael Sánchez-González, Mehrshad Pakdel, Julia von Blume, Birgit Blank, Natalia Pacheco-Fernandez, Angelika Hausser, Kathrin Weber, Franck Perez, Gisela Beck, Stefan Linder, Mai Ly Tran

Publikováno v: The Journal of Cell Biology : JCB
Journal of Cell Biology
Journal of Cell Biology, Rockefeller University Press, 2020, 219, ⟨10.1083/jcb.201907058⟩
The Journal of Cell Biology

Trafficking of matrix metalloproteinases (MMPs) through the Golgi remains enigmatic in the field. Pacheco-Fernandez et al. find that nucleobindin-1 (NUCB1), a cis-Golgi localized Ca2+-binding protein, plays a major role in this process by binding to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db30940044611ea100bc860a4e2adc15
https://hdl.handle.net/21.11116/0000-0007-4BE7-121.11116/0000-0007-4BE9-F

Secretory cargo sorting by Ca2+-dependent Cab45 oligomerization at the trans-Golgi network

Autor: Bianca Habermann, Alvaro H. Crevenna, Julia von Blume, Andreas Maiser, Gisela Beck, Jens Prescher, Don C. Lamb, Christine Kienzle, Kira Bartnik, Derya Emin, Heinrich Leonhardt, Mehrshad Pakdel, Birgit Blank

Publikováno v: The Journal of Cell Biology

Crevenna et al. examine the mechanism by which secretory cargoes are segregated at the trans-Golgi network (TGN) for release into the extracellular space. The authors demonstrate that Ca2+-dependent changes in Cab45 oligomerization mediate sorting of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1677bcb2dd1ddb9ee8fdfa675c96a0
https://doi.org/10.1083/jcb.201601089