Zobrazeno 1 - 10
of 452
pro vyhledávání: '"Birgit Schilling"'
Autor:
David V. Begelman, Bhavna Dixit, Carly Truong, Christina D. King, Mark A. Watson, Birgit Schilling, Martin D. Brand, Amutha Boominathan
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101372- (2024)
Replicative errors, inefficient repair, and proximity to sites of reactive oxygen species production make mitochondrial DNA (mtDNA) susceptible to damage with time. We explore in vivo allotopic expression (re-engineering mitochondrial genes and expre
Externí odkaz:
https://doaj.org/article/df6f8d7c84984156a9146f7f86548334
Autor:
Jordi Creus-Muncunill, Jean Vianney Haure-Mirande, Daniele Mattei, Joanna Bons, Angie V. Ramirez, B. Wade Hamilton, Chuhyon Corwin, Sarah Chowdhury, Birgit Schilling, Lisa M. Ellerby, Michelle E. Ehrlich
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-26 (2024)
Abstract Introduction Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the Huntingtin gene (HTT). Immune activation is abundant in the striatum of HD patients. Detection of ac
Externí odkaz:
https://doaj.org/article/b2af945c340e484f850a0185183190e3
Autor:
Charles A. Schurman, Serra Kaya, Neha Dole, Nadja M. Maldonado Luna, Natalia Castillo, Ryan Potter, Jacob P. Rose, Joanna Bons, Christina D. King, Jordan B. Burton, Birgit Schilling, Simon Melov, Simon Tang, Eric Schaible, Tamara Alliston
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-17 (2024)
Abstract Poor bone quality is a major factor in skeletal fragility in elderly individuals. The molecular mechanisms that establish and maintain bone quality, independent of bone mass, are unknown but are thought to be primarily determined by osteocyt
Externí odkaz:
https://doaj.org/article/c2c16007bc0342fcbf0738afdd0a91e6
Autor:
Elisa B. Moutin, Joanna Bons, Giada Giavara, Filipe Lourenco, Deng Pan, Jordan B. Burton, Samah Shah, Mathilde Colombé, Philippe Gascard, Thea Tlsty, Birgit Schilling, Douglas J. Winton
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 4, Pp 639-656 (2024)
Background & Aims: Chronic inflammatory illnesses are debilitating and recurrent conditions associated with significant comorbidities, including an increased risk of developing cancer. Extensive tissue remodeling is a hallmark of such illnesses, and
Externí odkaz:
https://doaj.org/article/fcc1fde8b09c421eb911020017c66e0f
Autor:
Kenneth A. Wilson, Sudipta Bar, Eric B. Dammer, Enrique M. Carrera, Brian A. Hodge, Tyler A. U. Hilsabeck, Joanna Bons, George W. Brownridge, Jennifer N. Beck, Jacob Rose, Melia Granath-Panelo, Christopher S. Nelson, Grace Qi, Akos A. Gerencser, Jianfeng Lan, Alexandra Afenjar, Geetanjali Chawla, Rachel B. Brem, Philippe M. Campeau, Hugo J. Bellen, Birgit Schilling, Nicholas T. Seyfried, Lisa M. Ellerby, Pankaj Kapahi
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Dietary restriction (DR) delays aging, but the mechanism remains unclear. We identified polymorphisms in mtd, the fly homolog of OXR1, which influenced lifespan and mtd expression in response to DR. Knockdown in adulthood inhibited DR-mediat
Externí odkaz:
https://doaj.org/article/3db7a1cee89643b094c27462834817ac
Publikováno v:
STAR Protocols, Vol 5, Iss 2, Pp 103074- (2024)
Summary: Lysine malonylation is a protein posttranslational modification. We present a protocol to generate stable gene-knockdown K562 cell lines through lentiviral infection of a CRISPR interference (CRISPRi) system followed by lysine malonylation m
Externí odkaz:
https://doaj.org/article/5ff7c7179f8a4985bab2dca07820f187
Autor:
Andrés Fuentes‐Flores, Cristian Geronimo‐Olvera, Karina Girardi, David Necuñir‐Ibarra, Sandip Kumar Patel, Joanna Bons, Megan C Wright, Daniel Geschwind, Ahmet Hoke, Jose A Gomez‐Sanchez, Birgit Schilling, Daniela L Rebolledo, Judith Campisi, Felipe A Court
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-18 (2023)
Abstract Following peripheral nerve injury, successful axonal growth and functional recovery require Schwann cell (SC) reprogramming into a reparative phenotype, a process dependent upon c‐Jun transcription factor activation. Unfortunately, axonal
Externí odkaz:
https://doaj.org/article/81de24a7030f424a99feff5a63cbe0ba
Autor:
Alexandra V. Schmidt, Sivakama S. Bharathi, Keaton J. Solo, Joanna Bons, Jacob P. Rose, Birgit Schilling, Eric S. Goetzman
Publikováno v:
Biomolecules, Vol 14, Iss 9, p 1160 (2024)
Sirtuin-2 (Sirt2), an NAD+-dependent lysine deacylase enzyme, has previously been implicated as a regulator of glucose metabolism, but the specific mechanisms remain poorly defined. Here, we observed that Sirt2−/− males, but not females, have dec
Externí odkaz:
https://doaj.org/article/313e585950c041e8a1492b3a783497cc
Autor:
Kizito-Tshitoko Tshilenge, Joanna Bons, Carlos Galicia Aguirre, Cristian Geronimo-Olvera, Samah Shah, Jacob Rose, Akos A. Gerencser, Sally K. Mak, Michelle E. Ehrlich, D. Cristopher Bragg, Birgit Schilling, Lisa M. Ellerby
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106367- (2024)
Summary: X-linked dystonia-parkinsonism (XDP) is a rare neurodegenerative disease endemic to the Philippines. The genetic cause for XDP is an insertion of a SINE-VNTR-Alu (SVA)-type retrotransposon within intron 32 of TATA-binding protein associated
Externí odkaz:
https://doaj.org/article/297c02029d604c4fb715e2e69b76c9cc
Autor:
Andres Fuentes-Flores, Cristian Geronimo-Olvera, David Necuñir-Ibarra, Sandip Kumar Patel, Joanna Bons, Megan Wright, Daniel Geschwind, Ahmet Höke, Jose Gomez Sanchez, Birgit Schilling, Judith Campisi, Felipe Court
Publikováno v:
IBRO Neuroscience Reports, Vol 15, Iss , Pp S226-S227 (2023)
Externí odkaz:
https://doaj.org/article/bf5172649e9341259d3c0181d37763e1