Zobrazeno 1 - 10
of 92
pro vyhledávání: '"Birgit, Schoeberl"'
Autor:
Anna Kondic, Dean Bottino, John Harrold, Jeffrey D. Kearns, CJ Musante, Aleksandrs Odinecs, Saroja Ramanujan, Jangir Selimkhanov, Birgit Schoeberl
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The goal of this mini-review is to summarize the collective experience of the authors for how modeling and simulation approaches have been used to inform various decision points from discovery to First-In-Human clinical trials. The article is divided
Externí odkaz:
https://doaj.org/article/cc2e644a24a548b9a118216b30197d39
Autor:
Enrico Ferrero, Sophie Brachat, Jeremy L Jenkins, Philippe Marc, Peter Skewes-Cox, Robert C Altshuler, Caroline Gubser Keller, Audrey Kauffmann, Erik K Sassaman, Jason M Laramie, Birgit Schoeberl, Mark L Borowsky, Nikolaus Stiefl
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 8, p e1008126 (2020)
Externí odkaz:
https://doaj.org/article/f082e4cb53aa47739dce312fd02efbf6
Autor:
Max Schelker, Sonia Feau, Jinyan Du, Nav Ranu, Edda Klipp, Gavin MacBeath, Birgit Schoeberl, Andreas Raue
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Mathematical approaches can be used to assess immune cell composition from the tumour's bulk expression data. Here the authors optimise the CYBERSORT-based deconvolution algorithm by including cell type-specific reference gene expression profiles gen
Externí odkaz:
https://doaj.org/article/5c63f788f9dd4251a8c28f805ab97385
Autor:
James D. Marks, Ulrik B. Nielsen, Birgit Schoeberl, Gregory P. Adams, Fraser Conrad, Jianlong Lou, Hao Zou, Brian D. Harms, Anne-Laure Goenaga, Yu Zhou
PDF file, 450KB, Biphasic distribution of the increase in binding affinity for conversion from monovalent to bivalent forms for antibodies with different intrinsic affinities.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dad4b36218fddcc93214aa8599e29c9
https://doi.org/10.1158/1535-7163.22498900.v1
https://doi.org/10.1158/1535-7163.22498900.v1
Autor:
James D. Marks, Ulrik B. Nielsen, Birgit Schoeberl, Gregory P. Adams, Fraser Conrad, Jianlong Lou, Hao Zou, Brian D. Harms, Anne-Laure Goenaga, Yu Zhou
PDF file, 95KB, Comparison of cell-binding curves for low and high affinity anti-EGFR IgG antibodies at the experimental incubation time and a hypothetical time.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d912714f35509e5cb38fad73680d2e5
https://doi.org/10.1158/1535-7163.22498897
https://doi.org/10.1158/1535-7163.22498897
Autor:
Ulrik B. Nielsen, Birgit Schoeberl, Arthur J. Kudla, Michael J. Feldhaus, Matt Wallace, Neeraj Kohli, Jinming Gu, Stephanie Nguyen, Ryan Overland, Lia Luus, Bo Zhang, Shinji Oyama, Violette Paragas, Sharlene Adams, Brian D. Harms, Alexandra Huhalov, Charlotte F. McDonagh
PDF file - 189K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::740c3b57b3148fec19b2a1932a1c942b
https://doi.org/10.1158/1535-7163.22498605
https://doi.org/10.1158/1535-7163.22498605
Autor:
Alexey A. Lugovskoy, Ulrik B. Nielsen, Birgit Schoeberl, Kenneth J. Olivier, Brian D. Harms, Yang Jiao, Maja Razlog, Rachel Rennard, Neeraj Kohli, Lihui Xu, Victoria Rimkunas, Jian Tang, Sergio Iadevaia, Sharlene Adams, Jason Baum, Bryan W. Johnson, Jonathan B. Fitzgerald
PDF - 111K, Additional details on the implementation and training of the mechanistic model.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a54401ccec2fdca3751258fe817721
https://doi.org/10.1158/1535-7163.22500898.v1
https://doi.org/10.1158/1535-7163.22500898.v1
Autor:
James D. Marks, Ulrik B. Nielsen, Birgit Schoeberl, Gregory P. Adams, Fraser Conrad, Jianlong Lou, Hao Zou, Brian D. Harms, Anne-Laure Goenaga, Yu Zhou
PDF file, 52KB, Comparison of measured apparent IgG affinities vs affinities calculated by using a mathematical model on cells of different EGFR density (A431, MDAMB468, and MDAMB231).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80173de6710a95bc7f5e6126c03912b9
https://doi.org/10.1158/1535-7163.22498879.v1
https://doi.org/10.1158/1535-7163.22498879.v1
Autor:
Alexey A. Lugovskoy, Ulrik B. Nielsen, Birgit Schoeberl, Kenneth J. Olivier, Brian D. Harms, Yang Jiao, Maja Razlog, Rachel Rennard, Neeraj Kohli, Lihui Xu, Victoria Rimkunas, Jian Tang, Sergio Iadevaia, Sharlene Adams, Jason Baum, Bryan W. Johnson, Jonathan B. Fitzgerald
Although inhibition of the insulin-like growth factor (IGF) signaling pathway was expected to eliminate a key resistance mechanism for EGF receptor (EGFR)-driven cancers, the effectiveness of IGF-I receptor (IGF-IR) inhibitors in clinical trials has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63aadf5ac0a5228ff209cf3c30de8a8a
https://doi.org/10.1158/1535-7163.c.6536614.v1
https://doi.org/10.1158/1535-7163.c.6536614.v1
Autor:
James D. Marks, Ulrik B. Nielsen, Birgit Schoeberl, Gregory P. Adams, Fraser Conrad, Jianlong Lou, Hao Zou, Brian D. Harms, Anne-Laure Goenaga, Yu Zhou
PDF file, 56KB, Kinetic parameters used in the computational model of antibody binding.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01eaae82ca847d4d1067a9547389809e
https://doi.org/10.1158/1535-7163.22498882
https://doi.org/10.1158/1535-7163.22498882