Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Birgit, Schiøtt"'
Autor:
Elad Arad, Kasper B. Pedersen, Orit Malka, Sisira Mambram Kunnath, Nimrod Golan, Polina Aibinder, Birgit Schiøtt, Hanna Rapaport, Meytal Landau, Raz Jelinek
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Antibiotic resistance of bacteria is considered one of the most alarming developments in modern medicine. While varied pathways for bacteria acquiring antibiotic resistance have been identified, there still are open questions concerning the
Externí odkaz:
https://doaj.org/article/2e6f4b67c7264031b3ec5edb8e5ec825
Autor:
Steven J. Roeters, Kris Strunge, Kasper B. Pedersen, Thaddeus W. Golbek, Mikkel Bregnhøj, Yuge Zhang, Yin Wang, Mingdong Dong, Janni Nielsen, Daniel E. Otzen, Birgit Schiøtt, Tobias Weidner
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract The amyloid aggregation of α-synuclein (αS), related to Parkinson’s disease, can be catalyzed by lipid membranes. Despite the importance of lipid surfaces, the 3D-structure and orientation of lipid-bound αS is still not known in detail.
Externí odkaz:
https://doaj.org/article/e2c70aa70bdf4978bba2517cd5c5812f
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The human dopamine transporter (hDAT) is one in three members of the monoamine transporter family (MAT). hDAT is essential for regulating the dopamine concentration in the synaptic cleft through dopamine reuptake into the presynaptic neuron;
Externí odkaz:
https://doaj.org/article/8672ebf9631d40e4bbb79de58c8abfae
Autor:
Mikkel Vestergaard, Nils Anton Berglund, Pin-Chia Hsu, Chen Song, Heidi Koldsø, Birgit Schiøtt, Mark S. P. Sansom
Publikováno v:
ACS Omega, Vol 4, Iss 20, Pp 18889-18899 (2019)
Externí odkaz:
https://doaj.org/article/2800c97b623748a18240b3c4f85c8be3
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Islet amyloid polypeptide (IAPP) is a proposed cause of the decreased beta-cell mass in patients with type-II diabetes. The molecular composition of the cell-membrane is important for regulating IAPP cytotoxicity and aggregation. Cholesterol is prese
Externí odkaz:
https://doaj.org/article/4d0e81fc59c54a07bd64be52dd95be0e
Autor:
Emil Laust Kristoffersen, Andrea Coletta, Line Mørkholt Lund, Birgit Schiøtt, Victoria Birkedal
Publikováno v:
Kristoffersen, E L, Coletta, A, Lund, L M, Schiøtt, B & Birkedal, V 2023, ' Inhibited complete folding of consecutive human telomeric G-quadruplexes ', Nucleic Acids Research, vol. 51, no. 4, pp. 1571-1582 . https://doi.org/10.1093/nar/gkad004
Noncanonical DNA structures, termed G-quadruplexes, are present in human genomic DNA and are important elements in many DNA metabolic processes. Multiple sites in the human genome have G-rich DNA stretches able to support formation of several consecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5705d774db627f9a31d52518caa97906
https://doi.org/10.1093/nar/gkad004
https://doi.org/10.1093/nar/gkad004
Autor:
Tone Bengtsen, Viktor L Holm, Lisbeth Ravnkilde Kjølbye, Søren R Midtgaard, Nicolai Tidemand Johansen, Giulio Tesei, Sandro Bottaro, Birgit Schiøtt, Lise Arleth, Kresten Lindorff-Larsen
Publikováno v:
eLife, Vol 9 (2020)
Nanodiscs are membrane mimetics that consist of a protein belt surrounding a lipid bilayer, and are broadly used for characterization of membrane proteins. Here, we investigate the structure, dynamics and biophysical properties of two small nanodiscs
Externí odkaz:
https://doaj.org/article/a171d85d99464a76b087a8e0b6ca30d5
Autor:
Lisbeth R. Kjølbye, Lars Sørensen, Jun Yan, Nils A. Berglund, Jesper Ferkinghoff-Borg, Carol V. Robinson, Birgit Schiøtt
Publikováno v:
Kjølbye, L R, Sørensen, L, Yan, J, Berglund, N A, Ferkinghoff-Borg, J, Robinson, C V & Schiøtt, B 2022, ' Lipid Modulation of a Class B GPCR : Elucidating the Modulatory Role of PI(4,5)P 2 Lipids ', Journal of Chemical Information and Modeling, vol. 62, no. 24, pp. 6788-6802 . https://doi.org/10.1021/acs.jcim.2c00635
Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) lipids have been shown to stabilize an active conformation of class A G-protein coupled receptors (GPCRs) through a conserved binding site, not present in class B GPCRs. For class B GPCRs, previous mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1cc6945e3055bdbe9efde2fc6f56687
https://doi.org/10.1021/acs.jcim.2c00635
https://doi.org/10.1021/acs.jcim.2c00635
Autor:
Laust Bavnhøj, Jan Heiner Driller, Lorena Zuzic, Amanda Dyrholm Stange, Birgit Schiøtt, Bjørn Panyella Pedersen
Publikováno v:
Nature Plants.
Sucrose import from photosynthetic tissues into the phloem is mediated by transporters from the low-affinity sucrose transporter family (SUC/SUT family). Furthermore, sucrose redistribution to other tissues is driven by phloem sap movement, the produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1b77ef064305121ab4ae41d2ebcfbfa
https://doi.org/10.1038/s41477-023-01421-0
https://doi.org/10.1038/s41477-023-01421-0
Autor:
Lina Malinauskaite, Saida Said, Caglanur Sahin, Julie Grouleff, Azadeh Shahsavar, Henriette Bjerregaard, Pernille Noer, Kasper Severinsen, Thomas Boesen, Birgit Schiøtt, Steffen Sinning, Poul Nissen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Neurotransmitter:sodium symporters (NSS) perform Na+-dependent amino-acid uptake, but a full structural description of their function is lacking. Here the authors present a structure of the bacterial NSS LeuT in the outward-oriented empty state and s
Externí odkaz:
https://doaj.org/article/0c4dfaf71bb84eee82b29dd34e8c741a