Výsledky vyhledávání - "Birgit, Kittel"

The Dog as a Second Species for Toxicology Testing Provides Value to Drug Development

Autor: Nancy Bower, William E. Achanzar, Virginie Boulifard, Peter R. Brinck, Birgit Kittel, John L. Vahle

Publikováno v: International Journal of Toxicology. 41:431-441

The objective of the pharmaceutical industry is to develop new drugs that are safe for human use. In many cases, the accepted approach codified in guidance from regulatory authorities to assess the nonclinical safety profile of potential pharmaceutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c8280d91d8e4206ca7f39a704c155a
https://doi.org/10.1177/10915818221125670

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Revised guides for organ sampling and trimming in rats and mice – Part 2

Autor: M. Gerard O'Sullivan, Christine Ruehl-Fehlert, Daniel Robert Roth, Gerd Morawietz, Jan Klapwijk, Peter F. Wadsworth, Birgit Kittel, Michael R. Elwell, Barbara Lenz

Publikováno v: Experimental and Toxicologic Pathology. 55:413-431

This is the second part of a series of three articles on trimming instructions of rat and mouse protocol organs and tissues in regulatory type toxicity studies, covering the respiratory, male and female genital, and the endocrine systems. The article

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c4f54ae4306b2412e7487c13d38dddb
https://doi.org/10.1078/0940-2993-00349

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Revised guides for organ sampling and trimming in rats and mice – Part 3

Autor: Kevin Keane, Christine Ruehl-Fehlert, Birgit Kittel, Sabine Halm, Anke Heuser, Axel Bube, Jürgen Hellmann, Gerd Morawietz

Publikováno v: Experimental and Toxicologic Pathology. 55:433-449

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::adf03f8f74bec34718ff2a62a6dbc3d4
https://doi.org/10.1078/0940-2993-00350

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Integrated preclinical photosafety testing strategy for systemically applied pharmaceuticals

Autor: Douglas C. Bauer, René Schaffner, Nathalie Runser Loll, Birgit Kittel, Jens Schümann, Stéphanie Boudon, Peter Ulrich, Jeannine Streich, Deborah Garcia

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 139(1)

Phototoxic properties of systemically applied pharmaceuticals may be the cause of serious adverse drug reactions. Therefore, a reliable preclinical photosafety assessment strategy, combining in vitro and in vivo approaches in a quantitative manner, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9b1c8d18cae3f388a6fa3f1b268c39
https://pubmed.ncbi.nlm.nih.gov/24519524

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RITA-Registry of Industrial Toxicology Animal data: The application of historical control data for Leydig cell tumors in rats

Autor: Eberhard Karbe, Birgit Kittel, Rupert Kellner, Matthias Rinke, Ulrich Deschl, Susanne Rittinghausen, Thomas Nolte

Publikováno v: Experimental and Toxicologic Pathology
Experimental and Toxicologic Pathology, Elsevier, 2011, 63 (7-8), pp.645. ⟨10.1016/j.etp.2010.05.006⟩

Historical data for Leydig cell tumors from untreated or vehicle treated rats from carcinogenicity studies collected in the RITA database are presented. Examples are given for analyses of these data for dependency on variables considered to be of pos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::598c082499762e7452c3d208469a1950
https://hal.archives-ouvertes.fr/hal-00734584

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Evaluation of lung tolerance of ethanol, propylene glycol, and sorbitan monooleate as solvents in medical aerosols

Autor: Michèle de Monte, Jérôme Montharu, Yvon Rabemampianina, Francis Gauthier, Sandrine Le Guellec, Patrice Diot, Birgit Kittel, Joël Guillemain

Publikováno v: Journal of aerosol medicine and pulmonary drug delivery. 23(1)

Aerosol therapy is an expanding technique allowing administration of drugs acting locally in the bronchial tree and lungs or acting systemically after absorption through the respiratory tract. However, the choice of solvents and adjuvants is a critic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb66f0639e61746ca3b8150c1d49afa
https://pubmed.ncbi.nlm.nih.gov/20131984

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Proliferative and nonproliferative lesions of the rat and mouse respiratory tract

Autor: Thomas Wöhrmann, Birgit Kittel, Ron Herbert, Roger A. Renne, Michael V. Pino, Martin Rosenbruch, Jack R. Harkema, Kasuke Nagano, Amy E. Brix, Pierre Tellier, Susanne Rittinghausen, David B. Lewis, Thomas H. March

Publikováno v: Toxicologic pathology. 37

The INHAND Project (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North Ame

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56eb0f36f587cf3ff4ad696f84ce0c3
https://pubmed.ncbi.nlm.nih.gov/20032296

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1st international ESTP expert workshop: 'Larynx squamous metaplasia'. A re-consideration of morphology and diagnostic approaches in rodent studies and its relevance for human risk assessment

Autor: Martin Rosenbruch, Roger Renne, Heinrich Ernst, Susanne Rittinghausen, Agnes Schulte, Rainer Bader, Thomas Wöhrmann, Jerry F. Hardisty, Wolfgang Kaufmann, Takanori Harada, Angelika Kolling, Birgit Kittel, Michael Pino

Publikováno v: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 61(6)

Invited international experts participated in a 2-day workshop organized by the European Society of Toxicologic Pathology (ESTP) to evaluate and discuss spontaneous and induced laryngeal lesions in rodents. The main purpose of the workshop was to agr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334ee9304e7e59f8f6016d2b934c544e
https://pubmed.ncbi.nlm.nih.gov/19285845

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Revised guides for organ sampling and trimming in rats and mice--Part 3. A joint publication of the RITA and NACAD groups

Autor: Gerd, Morawietz, Christine, Ruehl-Fehlert, Birgit, Kittel, Axel, Bube, Kevin, Keane, Sabine, Halm, Anke, Heuser, Jürgen, Hellmann

Publikováno v: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 55(6)

This is the third part of a series of three articles on trimming instructions of rat and mouse protocol organs and tissues in regulatory type toxicity studies, covering the urinary, nervous, musculoskeletal, cardiovascular, and lymphoreticular system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e72b410500b6135666de8c1700c84a64
https://pubmed.ncbi.nlm.nih.gov/15384249

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Revised guides for organ sampling and trimming in rats and mice--Part 2. A joint publication of the RITA and NACAD groups

Autor: Birgit, Kittel, Christine, Ruehl-Fehlert, Gerd, Morawietz, Jan, Klapwijk, Michael R, Elwell, Barbara, Lenz, M Gerard, O'Sullivan, Daniel R, Roth, Peter F, Wadsworth

Publikováno v: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 55(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::64e287f3b714c6d4e492089ac5a610db
https://pubmed.ncbi.nlm.nih.gov/15384248

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