Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Birgit, Geertz"'
Autor:
Constantin von Bibra, Aya Shibamiya, Andrea Bähr, Birgit Geertz, Maria Köhne, Tim Stuedemann, Jutta Starbatty, Verena Horneffer-van der Sluis, Ulrich C. Klostermeier, Nadja Hornaschewitz, Xinghai Li, Eckhard Wolf, Nikolai Klymiuk, Markus Krane, Christian Kupatt, Bernhard Hiebl, Thomas Eschenhagen, Florian Weinberger
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/b2f866000a454c14a8dba3101b884926
Autor:
Benjamin Kloth, Giulia Mearini, Florian Weinberger, Justus Stenzig, Birgit Geertz, Jutta Starbatty, Diana Lindner, Udo Schumacher, Hermann Reichenspurner, Thomas Eschenhagen, Marc N. Hirt
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract A short-term increase in ventricular filling leads to an immediate (Frank-Starling mechanism) and a slower (Anrep effect) rise in cardiac contractility, while long-term increased cardiac load (e.g., in arterial hypertension) decreases contra
Externí odkaz:
https://doaj.org/article/e97f01fb532e4bb386845e9e151fa9b8
Autor:
Kristin Wenzel, Elisabeth Krämer, Birgit Geertz, Lucie Carrier, Stephan B. Felix, Stephanie Könemann, Saskia Schlossarek
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
The ubiquitin-proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are the main proteolytic systems involved in cellular homeostasis. Since cardiomyocytes, as terminally differentiated cells, lack the ability to share damaged proteins wi
Externí odkaz:
https://doaj.org/article/2cd2198e0a0f4f1688a627357ad2f042
Autor:
Niels Pietsch, Christina Y. Chen, Svenja Kupsch, Lucas Bacmeister, Birgit Geertz, Marisol Herrera-Rivero, Hanna Voß, Elisabeth Krämer, Ingke Braren, Dirk Westermann, Hartmut Schlüter, Giulia Mearini, Saskia Schlossarek, Jolanda van der Velden, Matthew Caporizzo, Diana Lindner, Benjamin L. Prosser, Lucie Carrier
Publikováno v:
bioRxiv
RationaleHypertrophic cardiomyopathy (HCM) is the most common cardiac genetic disorder caused by sarcomeric gene variants and associated with left ventricular (LV) hypertrophy and diastolic dysfunction. The role of the microtubule network has recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e267baf0ee68a8949bbbbb4f7fb877eb
https://doi.org/10.1101/2023.05.25.542365
https://doi.org/10.1101/2023.05.25.542365
Autor:
Nikoleta Pavlaki, Kirstie A. De Jong, Birgit Geertz, Viacheslav O. Nikolaev, Alexander Froese
Publikováno v:
Cells, Vol 10, Iss 3, p 535 (2021)
3′,5′-Cyclic adenosine monophosphate (cAMP) is a ubiquitous second messenger which plays critical roles in cardiac function and disease. In adult mouse ventricular myocytes (AMVMs), several distinct functionally relevant microdomains with tightly
Externí odkaz:
https://doaj.org/article/3f4994f0220a42a5876fb76751398b50
Autor:
Felix W. Friedrich, Hannieh Sotoud, Birgit Geertz, Silvio Weber, Frederik Flenner, Silke Reischmann, Thomas Eschenhagen, Lucie Carrier, Ali El-Armouche
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 8, Iss C, Pp 87-94 (2015)
Aims: Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy, diastolic dysfunction and increased interstitial fibrosis. Current treatment is based on beta-adrenoceptor (AR) and calcium channel blockers. Since mice deficie
Externí odkaz:
https://doaj.org/article/e8c2dbbdb4be462c88dcc33c4e71d251
Autor:
Tim Stüdemann, Judith Rössinger, Christoph Manthey, Birgit Geertz, Rajiven Srikantharajah, Constantin von Bibra, Aya Shibamiya, Maria Köhne, Antonius Wiehler, J. Simon Wiegert, Thomas Eschenhagen, Florian Weinberger
Publikováno v:
Circulation. 146(15)
Background: Transplantation of pluripotent stem cell–derived cardiomyocytes represents a promising therapeutic strategy for cardiac regeneration, and the first clinical studies in patients with heart failure have commenced. Yet, little is known abo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91c75386f2d5583ba56900d593822496
https://pubmed.ncbi.nlm.nih.gov/36073365
https://pubmed.ncbi.nlm.nih.gov/36073365
Autor:
Constantin von Bibra, Aya Shibamiya, Andrea Bähr, Birgit Geertz, Maria Köhne, Tim Stuedemann, Jutta Starbatty, Nadja Hornaschewitz, Xinghai Li, Eckhard Wolf, Nikolai Klymiuk, Markus Krane, Christian Kupatt, Bernhard Hiebl, Thomas Eschenhagen, Florian Weinberger
Engineered heart tissue (EHT) transplantation represents an innovative, regenerative approach for heart failure patients. Late preclinical trials are underway, and the first clinical trial has started in 2021. Preceding studies revealed functional re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::263d536fef4df3e794f69165ceae98a1
https://doi.org/10.1101/2022.07.07.499077
https://doi.org/10.1101/2022.07.07.499077
Autor:
Christina Gedicke‐Hornung, Verena Behrens‐Gawlik, Silke Reischmann, Birgit Geertz, Doreen Stimpel, Florian Weinberger, Saskia Schlossarek, Guillaume Précigout, Ingke Braren, Thomas Eschenhagen, Giulia Mearini, Stéphanie Lorain, Thomas Voit, Patrick A. Dreyfus, Luis Garcia, Lucie Carrier
Publikováno v:
EMBO Molecular Medicine, Vol 5, Iss 7, Pp 1128-1145 (2013)
Abstract Exon skipping mediated by antisense oligoribonucleotides (AON) is a promising therapeutic approach for genetic disorders, but has not yet been evaluated for cardiac diseases. We investigated the feasibility and efficacy of viral‐mediated A
Externí odkaz:
https://doaj.org/article/2151f46ca23e4c23b5b19581f81c7297
Autor:
Maria Köhne, Charlotta Sophie Behrens, Tim Stüdemann, Constantin von Bibra, Eva Querdel, Aya Shibamiya, Birgit Geertz, Jakob Olfe, Ida Hüners, Stefan Jockenhövel, Michael Hübler, Thomas Eschenhagen, Jörg Siegmar Sachweh, Florian Weinberger, Daniel Biermann
Publikováno v:
European journal of cardio-thoracic surgery 62(2), (2022). doi:10.1093/ejcts/ezac111
European journal of cardio-thoracic surgery 62(2), (2022). doi:10.1093/ejcts/ezac111
Published by Oxford Univ. Press, Oxford
Published by Oxford Univ. Press, Oxford
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905ef2f096d428d62784805785e2a1ab