Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Birger Dieriks"'
Autor:
Deidre Jansson, Victor Birger Dieriks, Justin Rustenhoven, Leon C. D. Smyth, Emma Scotter, Miranda Aalderink, Sheryl Feng, Rebecca Johnson, Patrick Schweder, Edward Mee, Peter Heppner, Clinton Turner, Maurice Curtis, Richard Faull, Mike Dragunow
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Jansson et al. design a high content screening system to target inflammation in human brain cells of the blood–brain barrier (pericytes and endothelial cells) to identify inflammatory modifiers. They identify cardiac glycosides as powerful regulato
Externí odkaz:
https://doaj.org/article/16813cdb8f5946e8a7e3b8526d12998c
Autor:
Ashley Cai, Richard L.M. Faull, Maurice A. Curtis, Daniel Finley, Nicole R. Higgins, Josephine J. Wu, Emma L. Scotter, Cong Fan, Mervyn J. Monteiro, Miguel A. Prado, Christopher Shaw, Jessie E. Greenslade, Alexandra M. Whiteley, Teepu Siddique, Micaela Tatman, Birger Dieriks, Nhat T. T. Le
Publikováno v:
Proceedings of the National Academy of Sciences. 117:15230-15241
Mutations in UBQLN2 cause amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neurodegenerations. However, the mechanism by which the UBQLN2 mutations cause disease remains unclear. Alterations in proteins involved in autoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f41f9f51298f0160dfb7a4add9eb99fc
https://doi.org/10.1073/pnas.1917371117
https://doi.org/10.1073/pnas.1917371117
Autor:
Jiyan An, Natasha L. Grimsey, Sarah Waters, Birger Dieriks, Mike Dragunow, Clinton Turner, Robert Bowser, Maurice A. Curtis, Henry J. Waldvogel, Richard L.M. Faull, Helen C. Murray, Yibin Zhang, Molly E. V. Swanson, Emma L. Scotter
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
BackgroundAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving progressive degeneration of upper and lower motor neurons. Both lower motor neuron loss and the deposition of phosphorylated TDP-43 inclusions display region
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b134c086e59bb3f5338a9ecd9e49f7a8
https://doi.org/10.1186/s40478-021-01244-0
https://doi.org/10.1186/s40478-021-01244-0
Autor:
Brigid Ryan, Blake Highet, Natacha Coppieters, Mike Dragunow, Birger Dieriks, Malvindar Singh-Bains, Richard L.M. Faull, Helen C. Murray, Praju Vikas Anekal, Nasim F Mehrabi, Maurice A. Curtis
Publikováno v:
Journal of neurochemistryReferences. 157(4)
In situ hybridization (ISH) is a powerful tool that can be used to localize mRNA expression in tissue samples. Combining ISH with immunohistochemistry (IHC) to determine cell type provides cellular context of mRNA expression, which cannot be achieved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0c56a19e000b424da90b1389a82c7cf
https://pubmed.ncbi.nlm.nih.gov/33368239
https://pubmed.ncbi.nlm.nih.gov/33368239
Autor:
Helen C. Murray, Clinton Turner, Molly E. V. Swanson, Birger Dieriks, Alan P. Koretsky, Praju Vikas Anekal, Maurice A. Curtis, Leonardo Belluscio, Richard L.M. Faull
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-15 (2020)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Olfactory dysfunction is an early and prevalent symptom of Alzheimer’s disease (AD) and the olfactory bulb is a nexus of beta-amyloid plaque and tau neurofibrillary tangle (NFT) pathology during early AD progression. To mitigate the accumulation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f94d2b5e6636f9d9a3bdc14fb4e1796
https://doi.org/10.1186/s40478-020-00986-7
https://doi.org/10.1186/s40478-020-00986-7
Autor:
Mike Dragunow, Emma L. Scotter, Clinton Turner, Peter Heppner, Victor Birger Dieriks, Maurice A. Curtis, Patrick Schweder, Miranda Aalderink, Deidre Jansson, Leon Smyth, Justin Rustenhoven, Rebecca Johnson, Richard L.M. Faull, Sheryl Feng, Edward W. Mee
Neuroinflammation is a key component of virtually all neurodegenerative diseases; preceding neuronal loss and associating directly with cognitive impairment. Neuroinflammatory signals can originate and be amplified at barrier tissues such as brain va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bd1654a940a9361aa95a1dc3b3c536
https://doi.org/10.1101/2020.04.15.043588
https://doi.org/10.1101/2020.04.15.043588
Autor:
Birger Dieriks, Maurice A. Curtis, Helen C. Murray, Richard L.M. Faull, Clinton Turner, Taylor J. Stevenson
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Reduced olfactory function (hyposmia) is one of the most common non-motor symptoms experienced by those living with Parkinson’s disease (PD), however, the underlying pathology of the dysfunction is unclear. Recent evidence indicates that α-synucle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7573f751b9cca705b0702fee545ec604
http://europepmc.org/articles/PMC7174302
http://europepmc.org/articles/PMC7174302
Autor:
Richard L.M. Faull, Leon Smyth, Patrick Schweder, Thomas I. H. Park, Yewon Jung, Edward W. Mee, Peter Heppner, Johanna M. Montgomery, Justin Rustenhoven, Kevin Lee, Birger Dieriks, Mike Dragunow, Maurice A. Curtis, Clinton Turner
Publikováno v:
Brain Communications
The ability to characterize and study primary neurons isolated directly from the adult human brain would greatly advance neuroscience research. However, significant challenges such as accessibility of human brain tissue and the lack of a robust neuro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ca9d6ee84fefa4b35922053f7edb224
https://doi.org/10.1093/braincomms/fcaa171
https://doi.org/10.1093/braincomms/fcaa171
Autor:
Clinton Turner, Steve Cameron, Lakshini H. S. Mendis, Richard L.M. Faull, Bronwen Gardner, Maurice A. Curtis, Birger Dieriks
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports
In Parkinson’s disease (PD), the olfactory bulb is typically the first region in the body to accumulate alpha-synuclein aggregates. This pathology is linked to decreased olfactory ability, which becomes apparent before any motor symptoms occur, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2f5a1a928f5f8273769d676446911b4
http://link.springer.com/article/10.1038/s41598-017-10659-6
http://link.springer.com/article/10.1038/s41598-017-10659-6
Autor:
Victoria F. Low, Clinton Turner, Richard L.M. Faull, Helen C. Murray, Molly E. V. Swanson, Maurice A. Curtis, Birger Dieriks
Publikováno v:
Neuroscience. 330:359-375
Polysialated neural cell adhesion molecule (PSA-NCAM) is a membrane bound glycoprotein widely expressed during nervous system development. While commonly described in the neurogenic niches of the adult human brain, there is limited evidence of its di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17ab82b9e1aa7cda47e7ee293e46883
https://doi.org/10.1016/j.neuroscience.2016.06.003
https://doi.org/10.1016/j.neuroscience.2016.06.003