Commentary on the draft revised guideline on the environmental risk assessment of medicinal products for human use

Autor: Rhys Whomsley, Susanne Brendler-Schwaab, Eadaoin Griffin, John Jensen, Caroline Moermond, Birger Scholz, Laila Sortvik Nilssen, Henry Stemplewski, Ines Roennefahrt

Publikováno v: Environmental Sciences Europe, Vol 31, Iss 1, Pp 1-4 (2019)

Abstract Applicants for marketing authorisation for human medicinal products in the European Union must submit an environmental risk assessment which is assessed by assessors from the national competent authorities. The EMA guideline on the environme

Externí odkaz: https://doaj.org/article/f4f6990cc68c41c0b1fc1e039cc8cd54

Effects of the histone deacetylase inhibitor valproic acid on human pericytes in vitro.

Autor: Jakob Karén, Alejandro Rodriguez, Tomas Friman, Lennart Dencker, Christian Sundberg, Birger Scholz

Publikováno v: PLoS ONE, Vol 6, Iss 9, p e24954 (2011)

Microvascular pericytes are of key importance in neoformation of blood vessels, in stabilization of newly formed vessels as well as maintenance of angiostasis in resting tissues. Furthermore, pericytes are capable of differentiating into pro-fibrotic

Externí odkaz: https://doaj.org/article/8077904b187547388e02e5df0ee2a833

Commentary on the draft revised guideline on the environmental risk assessment of medicinal products for human use

Autor: Birger Scholz, Caroline Moermond, John Jensen, Rhys Whomsley, Henry Stemplewski, Susanne Brendler-Schwaab, Eadaoin Griffin, Ines Roennefahrt, Laila Sortvik Nilssen

Publikováno v: Whomsley, R, Brendler-Schwaab, S, Griffin, E, Jensen, J, Moermond, C, Scholz, B, Nilssen, L S, Stemplewski, H & Roennefahrt, I 2019, ' Commentary on the draft revised guideline on the environmental risk assessment of medicinal products for human use ', Environmental Sciences Europe, vol. 31, no. 1, 17 . https://doi.org/10.1186/s12302-019-0198-9
Environmental Sciences Europe, Vol 31, Iss 1, Pp 1-4 (2019)

Applicants for marketing authorisation for human medicinal products in the European Union must submit an environmental risk assessment which is assessed by assessors from the national competent authorities. The EMA guideline on the environmental risk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c254df97c050d05881ef4161d0aa3e
https://doi.org/10.1186/s12302-019-0198-9

Molecular Targets and Early Response Biomarkers for the Prediction of Developmental ToxicityIn Vitro

Autor: Kim Kultima, Anne-Lee Gustafson, Henrik Alm, Michael Stigson, Birger Scholz, Lennart Dencker, Måns Jergil

Publikováno v: Europe PubMed Central
Scopus-Elsevier

There is an urgent need for new in vitro methods to predict the potential developmental toxicity of candidate drugs in the early lead identification and optimisation process. This would lead to a reduction in the total number of animals required in f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa3c5ad54fc18b7088d678825248b2b
https://doi.org/10.1177/026119290703500313

Proteomic Evaluation of Neonatal Exposure to 2,2′,4,4′,5-Pentabromodiphenyl Ether

Autor: Kim Kultima, Lennart Dencker, Celia Fischer, Henrik Alm, Michael Stigson, Henrik Viberg, Birger Scholz, Per Eriksson

Publikováno v: Environmental Health Perspectives

Exposure to the brominated flame retardant 2,2 ,4,4 ,5-pentabromodiphenyl ether (PBDE-99) during the brain growth spurt disrupts normal brain development in mice and results in disturbed spontaneous behavior in adulthood. The neurodevelopmental toxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eca3f3ace061e4d1d9924e3a18853e5f
https://doi.org/10.1289/ehp.8419