Mertk Signaling and Immune Regulation in T cells.

Autor: Varsanyi C; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ, 07103., Birge RB; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ, 07103.

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2024 Dec 17. Date of Electronic Publication: 2024 Dec 17.

Regulation of Mertk Surface Expression via ADAM17 and γ-Secretase Proteolytic Processing.

Autor: Lahey KC; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, USA., Varsanyi C; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, USA., Wang Z; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, USA., Aquib A; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, USA., Gadiyar V; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, USA., Rodrigues AA; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, USA., Pulica R; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, USA., Desind S; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, USA., Davra V; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, USA., Calianese DC; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, USA., Liu D; Department of Pathology, Immunology and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07101, USA., Cho JH; Department of Pathology, Immunology and Laboratory Medicine, Center for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, NJ 07101, USA., Kotenko SV; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, USA., De Lorenzo MS; Department of Cell Biology and Molecular Medicine, New Jersey Medical School, 185 South Orange Ave, Newark, NJ 07103, USA., Birge RB; Department of Microbiology, Biochemistry and Molecular Genetics, Center for Cell Signaling, Rutgers New Jersey Medical School, 205 South Orange Ave, Newark, NJ 07103, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2024 Apr 17; Vol. 25 (8). Date of Electronic Publication: 2024 Apr 17.

Correction: Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis.

Autor: Gao L; Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, National Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China., He C; Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, National Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China., Yang A; Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, National Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China. yangaizhen@suda.edu.cn., Zhou H; Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215123, China., Lu Q; Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, 40202, USA., Birge RB; Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School Cancer Center, Rutgers University, Newark, NJ, USA. birgera@njms.rutgers.edu., Wu Y; Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Prevention, National Clinical Research Center for Hematologic Diseases, Cyrus Tang Medical Institute, Soochow University, Suzhou, 215123, China. yiwu99@gmail.com.; Sol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA, USA. yiwu99@gmail.com.

Publikováno v: Cell communication and signaling : CCS [Cell Commun Signal] 2023 Aug 31; Vol. 21 (1), pp. 225. Date of Electronic Publication: 2023 Aug 31.

Targeted degradation of MERTK and other TAM receptor paralogs by heterobifunctional targeted protein degraders.

Autor: Gadiyar V; Department of Microbiology, Biochemistry and Molecular Genetics, Cancer Center, Rutgers- New Jersey Medical School, Newark, NJ, United States., Patel G; Department of Microbiology, Biochemistry and Molecular Genetics, Cancer Center, Rutgers- New Jersey Medical School, Newark, NJ, United States., Chen J; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Vigil D; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Ji N; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Campbell V; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Sharma K; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Shi Y; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Weiss MM; Department of Research and Development, Kymera Therapeutics, Watertown, MA, United States., Birge RB; Department of Microbiology, Biochemistry and Molecular Genetics, Cancer Center, Rutgers- New Jersey Medical School, Newark, NJ, United States., Davra V; Department of Microbiology, Biochemistry and Molecular Genetics, Cancer Center, Rutgers- New Jersey Medical School, Newark, NJ, United States.

Publikováno v: Frontiers in immunology [Front Immunol] 2023 Jul 20; Vol. 14, pp. 1135373. Date of Electronic Publication: 2023 Jul 20 (Print Publication: 2023).

Dual Axl/MerTK inhibitor INCB081776 creates a proinflammatory tumor immune microenvironment and enhances anti-PDL1 efficacy in head and neck cancer.

Autor: Kostecki KL; Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Iida M; Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Wiley AL; Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Kimani S; Rutgers Biomedical Health and Sciences, Rutgers University, Newark, New Jersey, USA., Mehall B; Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Tetreault K; Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Alexandridis R; Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Yu M; Department of Biostatistics and Medical Informatics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Hong S; Pharmaceutical Sciences Division, University of Wisconsin School of Pharmacy, Madison, Wisconsin, USA.; Yonsei Frontier Lab and Department of Pharmacy, Yonsei University, Seoul, South Korea.; University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA., Salgia R; Department of Medical Oncology and Experimental Therapeutics, Comprehensive Cancer Center, City of Hope, Duarte, California, USA., Bruce JY; University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA., Birge RB; Rutgers Biomedical Health and Sciences, Rutgers University, Newark, New Jersey, USA., Harari PM; Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA., Wheeler DL; Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.; University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, USA.

Publikováno v: Head & neck [Head Neck] 2023 May; Vol. 45 (5), pp. 1255-1271. Date of Electronic Publication: 2023 Mar 20.