Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Birendra K. Bhattacharya"'
Publikováno v:
Nucleosides and Nucleotides. 14:1269-1287
A convenient synthesis of N1-methyl-2′-deoxy-ψ-uridine (ψ-thymidine, ψT, 7a) has been accomplished in good yield. The structural conformation of 7a was derived by 2D NMR and 1D NOE experiments. The nucleoside 7a has been incorporated into G-rich
Publikováno v:
Nucleosides and Nucleotides. 14:45-63
A convenient synthesis of 1-(2-deoxy-β-D-erythro-pentofuranosyl)quinazoline-2,4(3H)-dione ( 6 ) has been accomplished. The structural conformation of ( 6 ) was derived by 2D NMR, COSY and NOESY experiments. Nucleoside ( 6 ) was incorporated into G-r
Publikováno v:
J. Chem. Soc., Perkin Trans. 1. :1543-1550
A total synthesis of novel nucleosides 2′-deoxy-2′-arafluoro-tubercidin 12, -toyocamycin 23, -sangivamycin 24 and -thiosangivamycin 25 has been accomplished for the first time starting from 4-chloropyrrolo[2,3-d]pyrimidine 4, and 2-bromo-5-(ethox
Autor:
Birendra K. Bhattacharya, Yogesh S. Sanghvi, T. Sudhakar Rao, Ganapathi R. Revankar, Arthur F. Lewis, Roland K. Robins
Publikováno v:
Journal of Heterocyclic Chemistry. 30:1341-1349
A number of N- and C-alkyl derivatives of selected guanine analogs have been synthesized as potential antiviral agents. n-Pentyl, n-hexyl and 6-hydroxyhexyl derivatives in the imidazo[1,2-α]-s-triazine, 9–11, imid-azo[1,2-α]pyrimidine, 13–17, a
Publikováno v:
ChemInform. 26
Total synthesis of 2′-deoxy-2′-arafluoro analogues of toyocamycin 11, sangivamycin 12 and thiosangivamycin 13, starting from 5-bromo-2-ethoxymethyleneaminopyrrole-3,4-dicarbonitrile 4 has been accomplished for the first time.
Autor:
Ganapathi R. Revankar, Robert F. Rando, John H. Huffman, Joshua O. Ojwang, Birendra K. Bhattacharya
Publikováno v:
ChemInform. 27
Publikováno v:
Nucleosides and Nucleotides. 9:1021-1043
Methods are described for the synthesis of the α and β anomers of 7-D−ribofuranosylfuro[3,2-d]pyrimidines substituted at C-4 with either amino, oxo, thiono, or methylthio groups. The analogous 2,4-dithiono compounds are also described. The key st
Publikováno v:
Journal of Heterocyclic Chemistry. 27:787-793
6-Amino-1-(β-D-ribofuranosyl)-1H-pyrazolo[3,4-d]-1,3-oxazin-4-one (4), an isostere of the nucleoside antibiotic oxanosine has been synthesized from ethyl 5-amino-1-(2,3-O-isopropylidene-β-D-ribofuranosyl)pyrazole-4-carboxylate (6). Treatment of 6 w
Publikováno v:
Journal of Heterocyclic Chemistry. 27:795-801
A number of pyrazole ribonucleosides, structurally related to AICA riboside and ribavirin have been prepared and evaluated for their biological activity in vitro. Deisopropylidenation of 5-amino-1-(2,3-O-isopropylidene-β-D-ribofuranosyl)pyrazole-4-c
Autor:
Steven B. Larson, Ganesh D. Kini, Roland K. Robins, Birendra K. Bhattacharya, Steven S. Matsumoto, Yogesh S. Sanghvi, Ganapathi R. Revankar, Weldon B. Jolley
Publikováno v:
Journal of Medicinal Chemistry. 33:336-344
A series of 1,2,3-triazole (2), pyrazole (3 and 5), and pyrrole (4) ribonucleosides with two adjacent carbamoyl groups have been synthesized and evaluated for cell growth inhibition and induction of cellular differentiation of HL-60 cells in culture.