Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Biren K. Joshi"'
Autor:
Iris V. Paulus, Biren K. Joshi, Scott L. Sides, Eric S. Kraft, Thomas M. O’Connell, Andrew M. Wolters, Dan W. Reynolds, John M. Campbell, Byron S. Johnson, Stacey T. Long, Kevin L. Facchine
Publikováno v:
Journal of Pharmaceutical Sciences. 106:982-993
The chemical degradation of farglitazar (1) was investigated using a series of controlled stress testing experiments. Farglitazar drug substance was stressed under acidic, natural pH, basic, and oxidative conditions in solution. In the solid state, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1280688633c544c8fe8a50bb240d5b7a
https://doi.org/10.1016/j.xphs.2016.12.004
https://doi.org/10.1016/j.xphs.2016.12.004
Autor:
Matthew Jude Sharp, Will L. Canoy, Kae M. Bullock, Eric Eugene Boros, Xiao-ming M. Zhou, Richard T. Matsuoka, Greg A. Erickson, Vassil I. Elitzin, Mark B. Mitchell, Matthew C. Salmon, David H. Igo, Nicole M. Deschamps, Daniel W. Reynolds, Andrew D. Brown, Gregory E. Peckham, Istvan Kaldor, Jennifer F. Toczko, Shannon Condon, Carpenter Andrew J, Elie Amine Tabet, Jing M. Fang, Biren K. Joshi, Lianming Michael Wu, Jeremy D. Cobb
Publikováno v:
Organic Process Research & Development. 20:1469-1475
Practical and scalable syntheses were developed that were used to prepare multikilogram batches of GSK1292263A (1) and GSK2041706A (15), two potent G protein-coupled receptor 119 (GPR119) agonists. Both syntheses employed relatively cheap and readily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82876eef78eb10aca7f33fb50ec6c1c0
https://doi.org/10.1021/acs.oprd.6b00157
https://doi.org/10.1021/acs.oprd.6b00157
Publikováno v:
Journal of Natural Products. 65:1734-1737
Chemical studies of an organic extract from solid-substrate fermentations of the mycoparasitic fungus Humicola fuscoatra NRRL 22980, originally isolated as a colonist of Aspergillus flavus sclerotia, afforded two new unrelated compounds that we have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca2bfd22452f3cc0828376d3f2569d79
https://doi.org/10.1021/np020295p
https://doi.org/10.1021/np020295p
Autor:
Daniel W. Reynolds, Mark H. Kleinman, Paul Meers, Robert A. Reed, Biren K. Joshi, Christopher James Foti, Karen M. Alsante, Venkatramana M. Rao, Steven W. Baertschi, Andreas Abend, Margaret S. Landis, Kim Huynh-Ba
Publikováno v:
AAPS PharmSciTech. 15(1)
The American Association for Pharmaceutical Scientists (AAPS) Workshop on Predicting and Monitoring Impurities in API and Drug Products: Product Development and Regulatory Issues was held on October 13–14, 2012 at the McCormick Place in Chicago, IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3665b47f331e1843bc92334c7a9d4b6b
https://pubmed.ncbi.nlm.nih.gov/24281749
https://pubmed.ncbi.nlm.nih.gov/24281749
Autor:
Sara M. Hein, Leonard A. Smith, Vicki A. Montgomery, Ilja V. Khavrutskii, Nisarga L. Phatak, Donald T. Wicklow, Yvette Campbell, John H. Cardellina, Gregory J. Tawa, Xin Hu, Vanessa S. Eccard, Virginia I. Roxas-Duncan, Biren K. Joshi, James B. Gloer, Ashish G. Soman, Ulrich Höller, Anders Wallqvist
Publikováno v:
ACS medicinal chemistry letters. 3(5)
An in silico screen of the NIH Molecular Library Small Molecule Repository (MLSMR) of ∼350000 compounds and confirmatory bioassays led to identification of chaetochromin A (1) as an inhibitor of botulinum neurotoxin serotype A (BoNT A). Subsequent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a3df24aeeaece5f99591dbd0083846
https://pubmed.ncbi.nlm.nih.gov/24900483
https://pubmed.ncbi.nlm.nih.gov/24900483
Publikováno v:
ChemInform. 33
The annulation of thioamides with 2-alkynoates and 2,3-dienoates under the catalysis of tri-n-butylphosphine was described. The annulation reaction provided a new entry to thiazolines, particularly those with 2-aryl substituents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4af0f90b08c79fae73024bc29ffb8a6b
https://doi.org/10.1002/chin.200247113
https://doi.org/10.1002/chin.200247113
Autor:
Daniel E. Patterson, Biren K. Joshi, Beverly Ramsey, Michael P. Leblanc, Renetta Bryant-Mills, Scott L. Sides, Martin Osterhout, Royston C. B. Copley, Jeremiah Powers, Byron Johnson, Kevin L. Facchine
Publikováno v:
Journal of pharmaceutical sciences. 99(7)
Stress testing or forced degradation studies of denagliptin (1) tosylate in solution and solid-state, its blends with excipients, and capsules were conducted in order to elucidate degradation pathways, aid formulation development, and generate data t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3c86df700044face7823bc4adf5340
https://pubmed.ncbi.nlm.nih.gov/20112433
https://pubmed.ncbi.nlm.nih.gov/20112433
Publikováno v:
Journal of natural products. 63(7)
Scleramide (1), a new cyclic hexapeptide, and a new oxidized bisindolyl benzenoid derivative (2‘ ‘-oxoasterriquinol D methyl ether, 2) were isolated from extracts of the sclerotia of Aspergillus sclerotiorum (NRRL 5167). The structures of these c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5de12252b49c26210d858044c4112fe0
https://pubmed.ncbi.nlm.nih.gov/10924188
https://pubmed.ncbi.nlm.nih.gov/10924188
Publikováno v:
Journal of natural products. 62(5)
Four new compounds (1-4) have been isolated from solid-substrate fermentation cultures of the sclerotial mycoparasite Gliocladium catenulatum. The structures of verticillins D (1), E (2), and F (3) were assigned on the basis of MS and NMR data and ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebad002087f8d84a99a18e5c825d7c1
https://pubmed.ncbi.nlm.nih.gov/10346956
https://pubmed.ncbi.nlm.nih.gov/10346956