Chronic morphine treatment induces sex- and synapse-specific cellular tolerance on thalamo-cortical mu opioid receptor signaling.

Autor: Jaeckel ER; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, United States., Arias-Hervert ER; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, United States., Perez-Medina AL; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, United States., Schulz S; Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich-Schiller University, Jena, Germany., Birdsong WT; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan, United States.

Publikováno v: Journal of neurophysiology [J Neurophysiol] 2024 Sep 01; Vol. 132 (3), pp. 968-978. Date of Electronic Publication: 2024 Aug 07.

Chronic morphine induces adaptations in opioid receptor signaling in a thalamo-cortico-striatal circuit that are projection-dependent, sex-specific and regulated by mu opioid receptor phosphorylation.

Autor: Jaeckel ER; Department of Pharmacology, University of Michigan, Ann Arbor, MI., Arias-Hervert ER; Department of Pharmacology, University of Michigan, Ann Arbor, MI., Perez-Medina AL; Department of Pharmacology, University of Michigan, Ann Arbor, MI., Herrera YN; Department of Pharmacology, University of Michigan, Ann Arbor, MI., Schulz S; Institute of Pharmacology and Toxicology, Jena University Hospital, Friedrich-Schiller University, Jena, Germany., Birdsong WT; Department of Pharmacology, University of Michigan, Ann Arbor, MI.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Feb 14. Date of Electronic Publication: 2023 Feb 14.

Mu Opioid Receptors Acutely Regulate Adenosine Signaling in Striatal Glutamate Afferents.

Autor: Adhikary S; Vollum Institute, Oregon Health & Science University, Portland, Oregon, 97229., Jaeckel ER; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109., Birdsong WT; Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109 wtbird@umich.edu.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2022 Mar 23; Vol. 42 (12), pp. 2404-2417. Date of Electronic Publication: 2022 Jan 28.

Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry.

Autor: Arttamangkul S; The Vollum Institute, Oregon Health & Science University, Portland, United States., Plazek A; Medicinal Chemistry Core, Oregon Health & Science University, Portland, United States., Platt EJ; Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health & Science University, Portland, United States., Jin H; Medicinal Chemistry Core, Oregon Health & Science University, Portland, United States., Murray TF; Department of Pharmacology, School of Medicine, Creighton University, Omaha, United States., Birdsong WT; The Vollum Institute, Oregon Health & Science University, Portland, United States., Rice KC; Drug Design and Synthesis Section, Intramural Research Program, NIDA and NIAAA, Bethesda, United States., Farrens DL; Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health & Science University, Portland, United States., Williams JT; The Vollum Institute, Oregon Health & Science University, Portland, United States.

Publikováno v: ELife [Elife] 2019 Oct 07; Vol. 8. Date of Electronic Publication: 2019 Oct 07.

Synapse-specific opioid modulation of thalamo-cortico-striatal circuits.

Autor: Birdsong WT; Vollum Institute, Oregon Health & Science University, Portland, United States., Jongbloets BC; Vollum Institute, Oregon Health & Science University, Portland, United States., Engeln KA; Vollum Institute, Oregon Health & Science University, Portland, United States., Wang D; Department of Anesthesiology Perioperative and Pain Medicine, Stanford Neurosciences Institute, Stanford University, Stanford, United States.; Department of Molecular and Cellular Physiology, Stanford Neurosciences Institute, Stanford University, Stanford, United States.; Department of Neurosurgery, Stanford Neurosciences Institute, Stanford University, Stanford, United States., Scherrer G; Department of Anesthesiology Perioperative and Pain Medicine, Stanford Neurosciences Institute, Stanford University, Stanford, United States.; Department of Molecular and Cellular Physiology, Stanford Neurosciences Institute, Stanford University, Stanford, United States.; Department of Neurosurgery, Stanford Neurosciences Institute, Stanford University, Stanford, United States.; New York Stem Cell Foundation - Robertson Investigator, Stanford University, Palo Alto, United States., Mao T; Vollum Institute, Oregon Health & Science University, Portland, United States.

Publikováno v: ELife [Elife] 2019 May 17; Vol. 8. Date of Electronic Publication: 2019 May 17.