Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Biquan Luo"'
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39047 (2012)
GRP78, a master regulator of the unfolded protein response (UPR) and cell signaling, is required for inner cell mass survival during early embryonic development. However, little is known about its role in adult hematopoietic stem cells (HSCs) and hem
Externí odkaz:
https://doaj.org/article/a2ebcd0064e2421bb6611b8a2dce1de2
Autor:
Biquan Luo, Ben S Lam, Sung Hyung Lee, Shiuan Wey, Hui Zhou, Miao Wang, Si-Yi Chen, Gregor B Adams, Amy S Lee
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20364 (2011)
Hematopoietic stem cell (HSC) homeostasis in the adult bone marrow (BM) is regulated by both intrinsic gene expression products and interactions with extrinsic factors in the HSC niche. GRP94, an endoplasmic reticulum chaperone, has been reported to
Externí odkaz:
https://doaj.org/article/78031abefcef47068e248ce0efb9a3eb
Autor:
Changhui Mao, Miao Wang, Biquan Luo, Shiuan Wey, Dezheng Dong, Robin Wesselschmidt, Stephen Rawlings, Amy S Lee
Publikováno v:
PLoS ONE, Vol 5, Iss 5, p e10852 (2010)
Glucose-regulated protein 94 (GRP94) is one of the most abundant endoplasmic reticulum (ER) resident proteins and is the ER counterpart of the cytoplasmic heat shock protein 90 (HSP90). GRP94, a component of the GRP78 chaperone system in protein proc
Externí odkaz:
https://doaj.org/article/c41164acbf7c4493a0517e180ef1108a
Autor:
Amy S. Lee, Florence M. Hofman, Susan Groshen, Noah Craft, Kevin W. Bruhn, Zhi Liu, Risheng Ye, Genyuan Zhu, Niyati Jhaveri, Yi Zhang, Wei Ye, Shigang Xiong, Biquan Luo, Christopher Stapleton, Dezheng Dong
Supplementary Figure 1 from A Critical Role for GRP78/BiP in the Tumor Microenvironment for Neovascularization during Tumor Growth and Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e6274d07c5d6a81aaaa6fe0e013f19
https://doi.org/10.1158/0008-5472.22389476
https://doi.org/10.1158/0008-5472.22389476
Autor:
Amy S. Lee, Florence M. Hofman, Susan Groshen, Noah Craft, Kevin W. Bruhn, Zhi Liu, Risheng Ye, Genyuan Zhu, Niyati Jhaveri, Yi Zhang, Wei Ye, Shigang Xiong, Biquan Luo, Christopher Stapleton, Dezheng Dong
Supplementary Figure Legend from A Critical Role for GRP78/BiP in the Tumor Microenvironment for Neovascularization during Tumor Growth and Metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::499f981127b12ec12d60836063271ec9
https://doi.org/10.1158/0008-5472.22389473.v1
https://doi.org/10.1158/0008-5472.22389473.v1
Autor:
Amy S. Lee, Biquan Luo
Publikováno v:
Oncogene. 32:805-818
Cancer progression is characterized by rapidly proliferating cancer cells that are in need of increased protein synthesis. Therefore, enhanced endoplasmic reticulum (ER) activity is required to facilitate the folding, assembly and transportation of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196d5d006624a668019795ca7e5cb8a9
https://doi.org/10.1038/onc.2012.130
https://doi.org/10.1038/onc.2012.130
Autor:
Amy S. Lee, Louis Dubeau, Risheng Ye, Yong Fu, Miao Wang, Changhui Mao, Shengzhan Luo, David R. Hinton, Peter Baumeister, Ernesto Barron, Biquan Luo
Publikováno v:
Cell death and differentiation
Neurodegenerative diseases are often associated with dysfunction in protein quality control. The endoplasmic reticulum (ER), a key site for protein synthesis, senses stressful conditions by activating the unfolded protein response (UPR). In this stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffdc01476721f88e3372c6a38dea079
http://europepmc.org/articles/PMC2822118
http://europepmc.org/articles/PMC2822118
Autor:
Chun-Chih Tseng, Biquan Luo, Kyle Pfaffenbach, Gary Kanel, Bangyan L. Stiles, Amy S. Lee, Wan-Ting Chen
Liver cancer is one of the most common solid tumors, with poor prognosis and high mortality. Mutation or deletion of the tumor suppressor phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is strongly correlated with human liver cancer. G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac3bdb99f814051749df0bad8c33528
https://europepmc.org/articles/PMC4214272/
https://europepmc.org/articles/PMC4214272/
Autor:
Biquan Luo
Publikováno v:
Journal of Molecular and Genetic Medicine.
Myeloproliferative neoplasms (MPN) are chronic hematological neoplasms arising from the accumulation of genetic mutations in hematopoietic stem cells (HSCs). This notion is supported by genomic studies on MPN patients, in which recurrent mutations on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56a55a20035a9c1d8e563a4ecc575e2d
https://doi.org/10.4172/1747-0862.1000133
https://doi.org/10.4172/1747-0862.1000133
We have previously reported that acute inducible knockout of the endoplasmic reticulum chaperone GRP94 led to an expansion of the hematopoietic stem and progenitor cell pool. Here, we investigated the effectors and mechanisms for this phenomenon. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74dd15ed0c0a8b2dca78d9e7ad44e146
https://europepmc.org/articles/PMC3856911/
https://europepmc.org/articles/PMC3856911/