A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease RatsSummary

Autor: Jeremy D. Semrau, Roman S. Polishchuk, Andreas E. Kremer, Bipin S. Baral, Claudia Einer, Christine von Toerne, Gerald Denk, Hans Zischka, Sabine Borchard, Tamara Rieder, Josef Lichtmannegger, Karl Heinz Weiss, Stefanie M. Hauck, Alan A. DiSpirito, Jennifer-Christin Müller, Uwe Karst, Elena V. Polishchuk, Carola Eberhagen, Ralf Wimmer, Christin Leitzinger, Frauke Neff, Simon Hohenester, Bastian Popper

Publikováno v: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 3, Pp 571-596 (2019)
Cellular and Molecular Gastroenterology and Hepatology
Cell. Mol. Gast. Hept. 7, 571-596 (2019)

Background & Aims In Wilson disease, ATP7B mutations impair copper excretion into bile. Hepatic copper accumulation may induce mild to moderate chronic liver damage or even acute liver failure. Etiologic factors for this heterogeneous phenotype remai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f0127ca524307588532a6af17ccfa54
http://www.sciencedirect.com/science/article/pii/S2352345X18301802

Methanobactin from Methylocystis sp. Strain SB2 Affects Gene Expression and Methane Monooxygenase Activity in Methylosinus trichosporium OB3b

Autor: Alan A. DiSpirito, Alexey Vorobev, Bipin S. Baral, Jeremy D. Semrau, Bhagyalakshmi Kalidass, Muhammad Farhan Ul-Haque

Publikováno v: Applied and Environmental Microbiology. 81:2466-2473

Methanotrophs can express a cytoplasmic (soluble) methane monooxygenase (sMMO) or membrane-bound (particulate) methane monooxygenase (pMMO). Expression of these MMOs is strongly regulated by the availability of copper. Many methanotrophs have been fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6438bbc25701985810f8571256893d19
https://doi.org/10.1128/aem.03981-14

An Aminotransferase Is Responsible for the Deamination of the N-Terminal Leucine and Required for Formation of Oxazolone Ring A in Methanobactin of Methylosinus trichosporium OB3b

Autor: Bipin S. Baral, Alan A. DiSpirito, Wenyu Gu, Jeremy D. Semrau

Publikováno v: Applied and Environmental Microbiology. 83

Gene expression in methanotrophs has been shown to be affected by the availability of a variety of metals, most notably copper-regulating expression of alternative forms of methane monooxygenase. A copper-binding compound, or chalkophore, called meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2028f852ca8e87d06113fbe71986336
https://doi.org/10.1128/aem.02619-16

A TonB-dependent transporter is responsible for methanobactin uptake by Methylosinus trichosporium OB3b

Autor: Alan A. DiSpirito, Jeremy D. Semrau, Bipin S. Baral, Hans Zischka, Muhammad Farhan Ul Haque, Erick A. Turpin, Andrew Flatley, Wenyu Gu, Elisabeth Kremmer, Nathan L. Bandow

Publikováno v: Appl. Environ. Microbiol. 82, 1917-1923 (2016)

Methanobactin, a small modified polypeptide synthesized by methanotrophs for copper uptake, has been found to be chromosomally encoded. The gene encoding the polypeptide precursor of methanobactin, mbnA , is part of a gene cluster that also includes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc995a2400c4e19be2af9bba7aa55a02
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=47700

Methanobactin and MmoD work in concert to act as the 'copper-switch' in methanotrophs

Autor: Jeremy D, Semrau, Sheeja, Jagadevan, Alan A, DiSpirito, Ashraf, Khalifa, Julie, Scanlan, Brandt H, Bergman, Brittani C, Freemeier, Bipin S, Baral, Nathan L, Bandow, Alexey, Vorobev, Daniel H, Haft, Stéphane, Vuilleumier, J Colin, Murrell

Publikováno v: Environmental microbiology. 15(11)

Biological oxidation of methane to methanol by aerobic bacteria is catalysed by two different enzymes, the cytoplasmic or soluble methane monooxygenase (sMMO) and the membrane-bound or particulate methane monooxygenase (pMMO). Expression of MMOs is c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::486e427f4e7a116830527d41d902558c
https://pubmed.ncbi.nlm.nih.gov/23682956