Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Bipin N. Desai"'
Autor:
Christopher R. Dalton, Nizal S. Chandrakumar, Mark L. Boys, G. Allen Nickols, Mark Russell, Maureen A. Nickols, Michael Clare, Dale P. Spangler, John A. Wendt, Christina N. Steininger, William F. Westlin, Yaping Wang, Tiffany Duffin, Michael B. Tollefson, Jon A. Klover, Sandra K. Freeman, Melanie L. Hanneke, Scott B. Mohler, Mary Beth Finn, Maria N. Nguyen, Heather G. Stenmark, Jeffery L. Keene, Hongwei Wu, Bipin N. Desai, Barbara B. Chen, V. Wayne Engleman, Yi X. Yu, Sarah A. Norring, Marisa M. Westlin, Lori A. Schretzman, Downs Victoria Leigh, Ish K. Khanna, Thomas D. Penning
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:839-844
We describe a series of 1,2,4-oxadiazoles, which are potent antagonists of the integrin alpha(v)beta3 and, in addition, show selectivity relative to the other beta3 integrin alpha(IIb)beta3. In whole cells, the majority of these analogs also demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::701f9513e934e8bf576a289475c31d0e
https://doi.org/10.1016/j.bmcl.2005.11.008
https://doi.org/10.1016/j.bmcl.2005.11.008
Autor:
Thomas D. Penning, Nizal S. Chandrakumar, Barbara B. Chen, Helen Y. Chen, Bipin N. Desai, Stevan W. Djuric, Stephen H. Docter, Alan F. Gasiecki, Richard A. Haack, Julie M. Miyashiro, Mark A. Russell, Stella S. Yu, David G. Corley, Richard C. Durley, Brian F. Kilpatrick, Barry L. Parnas, Leslie J. Askonas, James K. Gierse, Elizabeth I. Harding, Maureen K. Highkin, James F. Kachur, Suzanne H. Kim, Gwen G. Krivi, Doreen Villani-Price, E. Yvonne Pyla, Walter G. Smith, Nayereh S. Ghoreishi-Haack
Publikováno v:
Journal of Medicinal Chemistry. 43:721-735
Leukotriene B(4) (LTB(4)) is a pro-inflammatory mediator that has been implicated in the pathogenesis of a number of diseases including inflammatory bowel disease (IBD) and psoriasis. Since the action of LTA(4) hydrolase is the rate-limiting step for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2c8b8f857645ec82bda0e73ed60429
https://doi.org/10.1021/jm990496z
https://doi.org/10.1021/jm990496z
Autor:
Bipin N. Desai, Aziz Karim, Susan M. Garthwaite, Chyung S. Cook, Keitaro Hashimoto, James M. Andress, J. Gerald Toole, Ferro Leonard J
Publikováno v:
Cardiovascular Drug Reviews. 13:19-32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba70e22300cb40ba67d4bd6abbcfa2f8
https://doi.org/10.1111/j.1527-3466.1995.tb00211.x
https://doi.org/10.1111/j.1527-3466.1995.tb00211.x
Autor:
Doreen Villani-Price, Suzanne H Kim, Walter G. Smith, Leslie J Askonas, Elizabeth I Harding, Maureen K Highkin, Thomas D. Penning, Alan F. Gasiecki, Nayereh S Ghoreishi-Haack, Nizal S Chandrakumar, E.Yvonne Pyla, Bipin N Desai, James F Kachur, Mark A Russell, Stevan W Djuric, James W. Malecha, James K. Gierse, Julie M Miyashiro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:1137-1139
The synthesis and biological evaluation of a series of heterocyclic analogues of the previously reported LTA(4) hydrolase inhibitor 1b are described. Imidazopyridine and purine analogues are specifically highlighted with several demonstrating excelle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6830ee52b64cb2d30d9d134d0185d9a9
https://doi.org/10.1016/s0960-894x(03)00039-8
https://doi.org/10.1016/s0960-894x(03)00039-8
Autor:
Kristen E. Shannon, Barbara B. Chen, James W. Malecha, Stephen H Docter, G. Allen Nickols, Thomas D. Penning, Marisa M. Westlin, Glen J. Gesicki, Chi-Dean Liang, Helen Y. Chen, David J. Edwards, Melanie L. Hanneke, Bipin N. Desai, Stella S. Yu, Sandra K. Freeman, Mark A. Russell, V. Wayne Engleman
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(6)
We describe a series of conformationally-restricted cinnamic acid peptidomimetics as well as several cinnamic acid isosteres, including 3-phenylpropionic acids, 2-amino-3-phenylpropionic acids, phenoxyacetic acids and 2-phenylcyclopropylcarboxylic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4de8232a0f6064585fd6a250b89418
https://pubmed.ncbi.nlm.nih.gov/15006384
https://pubmed.ncbi.nlm.nih.gov/15006384
Autor:
Maureen K Highkin, Leslie J Askonas, Doreen Villani-Price, Chi-Dean Liang, Bipin N Desai, Thomas D. Penning, James F Kachur, Elizabeth I Harding, Nayereh S Ghoreishi-Haack, Mark A Russell, Julie M Miyashiro, Walter G. Smith, E.Yvonne Pyla, Nizal S Chandrakumar, Stevan W Djuric, Suzanne H Kim, James K. Gierse, Alan F. Gasiecki
Publikováno v:
Bioorganicmedicinal chemistry letters. 12(23)
The synthesis and biological evaluation of a series of functionalized pyrrolidine- and piperidine-containing analogues of our lead LTA(4) hydrolase inhibitor, SC-57461A, is described. A number of compounds showed excellent potency in our in vitro scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bec3c88d96d40830db918a67cb8307f
https://pubmed.ncbi.nlm.nih.gov/12419366
https://pubmed.ncbi.nlm.nih.gov/12419366
Autor:
Robert J. Chorvat, Bipin N. Desai, J. E. Miller, E. Rohrbacher, Suzanne Evans Radak, K. T. Mclaughlin, C. Jett
Publikováno v:
Journal of Medicinal Chemistry. 28:194-200
A series of 22-hydroxycholesterol derivatives with a modified side chain terminus was prepared. These agents were evaluated in vitro and in vivo for their ability to suppress HMG CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2abc32e70bf670eb459e967500122744
https://doi.org/10.1021/jm00380a008
https://doi.org/10.1021/jm00380a008
Autor:
John H. Dygos, Bipin N. Desai
Publikováno v:
The Journal of Organic Chemistry. 44:1590-1596
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4085f3003eca8af404890ebce06ac7f7
https://doi.org/10.1021/jo01324a002
https://doi.org/10.1021/jo01324a002
Publikováno v:
The Journal of Organic Chemistry. 40:1328-1331
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29796656d5fa6b34074d2bc927ad9968
https://doi.org/10.1021/jo00897a032
https://doi.org/10.1021/jo00897a032
Autor:
Robert J. Chorvat, James D. Hirsch, Suzanne Evans Radak, James L. Bloss, Stanley S. Tenen, Bipin N. Desai
Publikováno v:
Journal of Medicinal Chemistry. 26:845-850
A series of oxopyridobenzothiazines (azaphenothiazines) were prepared and evaluated for binding to the benzodiazepine receptor, anticonvulsant activity in the pentylenetetrazole-induced convulsion assay, and, in two cases, ability to increase punishe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65702037fa73874c9c5da87829709518
https://doi.org/10.1021/jm00360a011
https://doi.org/10.1021/jm00360a011