Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Bioseparations and Downstream Processing"'
Autor:
Anna Christler, Theresa Scharl, Michael Melcher, Johannes Köppl, Anne Tscheließnig, Cabir Toy, Astrid Dürauer, Alois Jungbauer, Dominik G. Sauer
Publikováno v:
Biotechnology and Bioengineering
Technological developments require the transfer to their location of application to make use of them. We describe the transfer of a real‐time monitoring system for lab‐scale preparative chromatography to two new sites where it will be used and de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c01d3eeb848f75ef6fad5b05663b7c
http://europepmc.org/articles/PMC8518415
http://europepmc.org/articles/PMC8518415
Publikováno v:
Biotechnology and Bioengineering
Straight‐through chromatography, wherein the eluate from one column passes directly onto another column without adjustment, is one strategy to integrate and intensify manufacturing processes for biologics. Development and optimization of such strai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517eed128a248e06b073ea4a34c0ff17
https://doi.org/10.1002/bit.27767
https://doi.org/10.1002/bit.27767
Publikováno v:
Biotechnology and Bioengineering
A new method was proposed for increasing the capture chromatography process efficiency, linear flow‐velocity gradient (LFG). The method uses a linear decreasing flow‐velocity gradient with time during the sample loading. The initial flow velocity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ccf101b555c60134e9f122cb45634f
https://doi.org/10.1002/bit.27649
https://doi.org/10.1002/bit.27649
Autor:
Jure Sencar, Nikolaus Hammerschmidt, Thomas R. Kreil, Alois Jungbauer, Johanna Kindermann, Andreas Flicker, Duarte L. Martins
Publikováno v:
Biotechnology and Bioengineering
Continuous virus inactivation (VI) has received little attention in the efforts to realize fully continuous biomanufacturing in the future. Implementation of continuous VI must assure a specific minimum incubation time, typically 60 min. To guarantee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f7ad716973b315309da0a060c68c24e
https://doi.org/10.1002/bit.27292
https://doi.org/10.1002/bit.27292
Publikováno v:
Biotechnology and Bioengineering
This study describes the use of a previously reported chimerised monoclonal antibody (mAb), ch2448, to kill human embryonic stem cells (hESCs) in vivo and prevent or delay the formation of teratomas. ch2448 was raised against hESCs and was previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd9e6af291b401f2eed087ecbac073a
https://doi.org/10.1002/bit.27135
https://doi.org/10.1002/bit.27135
Autor:
Nicole Walch, Theresa Scharl-Hirsch, Dominik Georg Sauer, Magdalena Mosor, Friedrich Leisch, Astrid Dürauer, Alois Jungbauer, Michael Melcher, Matthias Berkemeyer
Publikováno v:
Biotechnology and Bioengineering
Process analytical technology combines understanding and control of the process with real‐time monitoring of critical quality and performance attributes. The goal is to ensure the quality of the final product. Currently, chromatographic processes i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7effe83279dafe67c7c749939fd611c0
https://doi.org/10.1002/bit.26984
https://doi.org/10.1002/bit.26984
Publikováno v:
Biotechnology and Bioengineering
We evaluated filtration behavior and virus removal capability for a monoclonal antibodies (mAb) and plasma IgG under constant flow rate directly following flow‐through column chromatography in an integrated process. mAb solution with quantified hos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5305c0e18ef6e91c80dc55b79fc9e0ff
https://pubmed.ncbi.nlm.nih.gov/34032276
https://pubmed.ncbi.nlm.nih.gov/34032276
Autor:
Jing Liao, Yan An, Xinliu Gao, Michael Swanson, Kirby Martinez-Fonts, Fengqiang Wang, Li Xiao, Vibha Jawa, Jorge Alexander Pavon, Simon Letarte, Douglas D. Richardson, Edward C. Sherer, Xuanwen Li
Publikováno v:
Biotechnology Progress
Host cell proteins (HCPs) are process‐related impurities derived from host organisms, which need to be controlled to ensure adequate product quality and safety. In this study, product quality attributes were tracked for several monoclonal antibodie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbb6f7d6bd798e79aaa24c0e36af4654
https://doi.org/10.1002/btpr.3128
https://doi.org/10.1002/btpr.3128
Autor:
Shawn Liu, Ivan Cui, Shyam Panjwani, June X. Zou, Konstantinos Spetsieris, Oliver Hesse, Wensheng Wang, Michal Mleczko, Roger Canales, Mohammad Anwaruzzaman
Publikováno v:
Biotechnology Progress
The production of recombinant therapeutic proteins from animal or human cell lines entails the risk of endogenous viral contamination from cell substrates and adventitious agents from raw materials and environment. One of the approaches to control su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4a9087be43d594b4415d56de107268
https://doi.org/10.1002/btpr.3135
https://doi.org/10.1002/btpr.3135
Autor:
J. Christopher Love, Chaz Goodwine, Neil C. Dalvie, Kerry R. Love, Sergio A. Rodriguez, Mariana Puntel, Steven M. Cramer, Viviana Parreño, Lucia Rocha, Andrés Wigdorovitz, Carla Sosa Holt, Laura E. Crowell, Mary Kate Tracey, Celina G. Vega
Publikováno v:
Wiley
Biotechnology and Bioengineering
Biotechnology and Bioengineering
Single‐domain antibodies (sdAbs) offer the affinity and therapeutic value of conventional antibodies, with increased stability and solubility. Unlike conventional antibodies, however, sdAbs do not benefit from a platform manufacturing process. Whil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a19bb206b6d4f767346acc2fd54fd50
https://hdl.handle.net/1721.1/135524
https://hdl.handle.net/1721.1/135524
