Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media

Autor: Alexandra Teleki, Olivia Nylander, Christel A.S. Bergström

Publikováno v: Pharmaceutics, Vol 12, Iss 6, p 493 (2020)

The intrinsic dissolution rate (IDR) of active pharmaceutical ingredients (API) is a key property that aids in early drug development, especially selecting formulation strategies to improve dissolution and thereby drug absorption in the intestine. He

Externí odkaz: https://doaj.org/article/f2860a4247de420888264313978915b0

APPLICATION OF A NATURAL ANTIOXIDANT FOR PROTECT FEED VITAMIN A

Autor: Li, N.G., Senotrusova, T.A., Son, O.M., Podvolotskaya, A.B., Ershova, T.A., Levchuk, T.V.

The article discusses aspects that affect the stability and bioavailability of feed vitamin A, as well as the importance of using antioxidants to protect feed vitamin A during storage. The aim of the study was to study the effect of antioxidants from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::629ad1d864e87db1d09ff1996655a37f

Affinity of Lipophilic Drugs to Mixed Lipid Aggregates in Simulated Gastrointestinal Fluids

Autor: Panagiota Zarmpi, Jonas H Fagerberg, Hasnaa Jabbar, Nikoletta Fotaki

Publikováno v: Fagerberg, J H, Zarmpi, P, Jabbar, H & Fotaki, N 2021, ' Affinity of Lipophilic Drugs to Mixed Lipid Aggregates in Simulated Gastrointestinal Fluids ', Journal of Pharmaceutical Sciences, vol. 110, no. 1, pp. 186-197 . https://doi.org/10.1016/j.xphs.2020.09.053

Mixed lipid aggregates, comprising of bile salts and phospholipids, present in the small intestine assist in drug solubilization and subsequent drug dissolution and absorption through the intestinal epithelium. The increased variability in their leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca67a0cd726ecd4f6056ae6a46860e5
https://purehost.bath.ac.uk/ws/files/214916433/Lipophilic_drugs_and_mixed_aggregates_Dr_N_Fotaki.pdf

Intrinsic Dissolution Rate Profiling of Poorly Water-Soluble Compounds in Biorelevant Dissolution Media

Autor: Teleki, Alexandra, Nylander, Olivia, Bergström, Christel A.S.

Publikováno v: Pharmaceutics
Volume 12
Issue 6
Pharmaceutics, Vol 12, Iss 493, p 493 (2020)

The intrinsic dissolution rate (IDR) of active pharmaceutical ingredients (API) is a key property that aids in early drug development, especially selecting formulation strategies to improve dissolution and thereby drug absorption in the intestine. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::0e6f106c4d538f42fdf6405c7f0f701b

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