Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Bioreductive drug"'
Autor:
Nicole Lecot, Belén Dávila, Carina Sánchez, Marcelo Fernández, Mercedes González, Pablo Cabral, Hugo Cerecetto, Romina Glisoni
Publikováno v:
Polymers; Volume 14; Issue 1; Pages: 71
Polymers
Polymers, Vol 14, Iss 71, p 71 (2022)
Polymers
Polymers, Vol 14, Iss 71, p 71 (2022)
2-Amino-7-fluorophenazine 5,10-dioxide (FNZ) is a bioreducible prodrug, poorly soluble in water, with potential anticancer activity on hypoxic-tumors. This poor solubility limits its potential applications in clinic. Amphiphilic pristine polymeric mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3338cf758e16ecac830ac9fa517a75a
Autor:
Eun K. Choi, Kaoru Terai, In-Mi Ji, Yeon H. Kook, Kyung H. Park, Eun T. Oh, Robert J. Griffin, Byung U. Lim, Jin-Seok Kim, Doo S. Lee, David A. Boothman, Melissa Loren, Chang W. Song, Heon Joo Park
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 8, Pp 634-642 (2007)
We found that (β-Lapachone ((β-Lap), a novel bioreductive drug, caused rapid apoptosis, clonogenic cell death in A549 human lung epithelial cancer cells in vitro in a dose-dependent manner. The clonogenic cell death caused by (β-Lap could be signi
Externí odkaz:
https://doaj.org/article/d5fb5abdfc0140cea846617cc3fda72d
Akademický článek
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Publikováno v:
Chinese Chemical Letters. 27(1):51-54
We have explored the chemistry of N -oxide heterocycles and imidazoles replacing ring D of the natural product (+)-calanolide A, and have synthesized 12 new analogues, two of which were active against both R Mtb and NR Mtb with MIC values of 12.5 μg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab29c01b9b296e801148f5c89e832298
Akademický článek
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Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 9:1595-1606
Bioreductive drugs are a class of hypoxia selective drugs that are designed to eradicate the hypoxic fraction of solid tumors. Their activity depends upon a number of biological and pharmacological factors and we used a mathematical modeling approach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34bde012c5475b8cd0523e2085e0a8c5
https://doi.org/10.1109/tcbb.2012.118
https://doi.org/10.1109/tcbb.2012.118
Autor:
Dinorah Gambino
Publikováno v:
Current Medicinal Chemistry. 17:3616-3631
Medicinal Inorganic Chemistry offers the high diversity of metal coordination chemistry for the development of bioactive compounds for therapeutic or diagnostic medicinal purposes. The design of novel metal-based antitumor agents occupies a privilege
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004320317d7a051e6d19fad858735e90
https://doi.org/10.2174/092986710793213797
https://doi.org/10.2174/092986710793213797
Autor:
Kaoru Terai, Heon Joo Park, Yeon Hee Kook, Doo Sung Lee, David A. Boothman, Jin-Seok Kim, Kyung Hwa Park, In-Mi Ji, Robert J. Griffin, Byung U. Lim, Chang W. Song, Eun Tax Oh, Eun Kyung Choi, Melissa L. Loren
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 8, Pp 634-642 (2007)
We found that (β-Lapachone ((β-Lap), a novel bioreductive drug, caused rapid apoptosis, clonogenic cell death in A549 human lung epithelial cancer cells in vitro in a dose-dependent manner. The clonogenic cell death caused by (β-Lap could be signi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c3ca70315c54c706307a7537aa892d
Autor:
Körner, Cindy
Hypoxia (low physiological O2 levels) is a characteristic of solid tumours. It not only alters the chemical microenvironment of a tumour but initiates a number of mechanisms which enable cells to cope and thrive under these conditions, resulting in t
Externí odkaz:
http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.692870
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 1:17-29
Advances in the chemistry of bioreductive drug activation have led to the design of hypoxia-selective drug delivery systems. These prodrugs, comprising a bioreductive "trigger", "linker" and "effector" were first explored with nitrobenzyl quaternary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e748c592f1c95ea7343383d49033f7
https://doi.org/10.2174/1389557013407241
https://doi.org/10.2174/1389557013407241