Zobrazeno 1 - 10
of 970
pro vyhledávání: '"Biophysique"'
Autor:
Lemay-St-Denis, Claudèle
L’habileté des enzymes à évoluer joue un rôle fondamental dans l'adaptation des organismes à leur environnement, leur permettant de s'adapter aux changements de température, aux nutriments disponibles ou encore à l'introduction de composés
Autor:
Lacroix, Gabriel
Les canaux de potassium voltage-dépendant (Kv) sont des tétramères séparés en 12 familles. Chaque sous-unité est composée de six segments transmembranaires (S1-S6). Les quatre premiers (S1-S4) forment le senseur de voltage dont le rôle est de
Externí odkaz:
http://hdl.handle.net/1866/32250
Publikováno v:
Biochemical Society Transactions. 51:447-456
RAS drug development has made enormous strides in the past ten years, with the first direct KRAS inhibitor being approved in 2021. However, despite the clinical success of covalent KRAS-G12C inhibitors, we are immediately confronted with resistances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24f9df84b6601766900c8063de8aa8d
https://doi.org/10.1042/bst20221343
https://doi.org/10.1042/bst20221343
The small GTPase Ras is frequently mutated in cancer and a driver of tumorigenesis. The recent years have shown great progress in drug-targeting Ras and understanding how it operates on the plasma membrane. We now know that Ras is non-randomly organi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100f9f08e13a1bc414ac43e3eb65bab5
http://hdl.handle.net/10138/358333
http://hdl.handle.net/10138/358333
Autor:
Sciortino, Alessia
Affecting over 10 million people worldwide, Parkinson’s disease is the second most common neurodegenerative disorder. With only 10% of cases having a known genetic cause, PD aetiology largely remains an enigma. Endogenous factors such as genetic pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2658::4c92b97be88bf749b5ae8f3d5de12a2c
http://orbilu.uni.lu/handle/10993/55283
http://orbilu.uni.lu/handle/10993/55283
Autor:
Mulica, Patrycja
With its high prevalence among the elderly, the movement disorder Parkinson’s disease (PD) poses a major challenge for our society. Unfortunately, despite continuous efforts from the research community, we still lack the disease-modifying treatment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2658::a963799a4155c5a51ca73126e9f88fe8
http://orbilu.uni.lu/handle/10993/55426
http://orbilu.uni.lu/handle/10993/55426
Autor:
Antonello E. Rigamonti, Gianfranco Frigerio, Diana Caroli, Alessandra De Col, Silvano G. Cella, Alessandro Sartorio, Silvia Fustinoni
Publikováno v:
Nutrients
Volume 15
Issue 3
Pages: 529
Volume 15
Issue 3
Pages: 529
Metabolomics applied to assess the response to a body weight reduction program (BWRP) may generate valuable information concerning the biochemical mechanisms/pathways underlying the BWRP-induced cardiometabolic benefits. The aim of the present study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41ce14ce4662536a3e13d21797d7267
http://orbilu.uni.lu/handle/10993/54010
http://orbilu.uni.lu/handle/10993/54010
Autor:
Assia Tiane, Melissa Schepers, Rick A. Reijnders, Lieve van Veggel, Sarah Chenine, Ben Rombaut, Emma Dempster, Catherine Verfaillie, Kobi Wasner, Anne Grünewald, Jos Prickaerts, Ehsan Pishva, Niels Hellings, Daniel van den Hove, Tim Vanmierlo
IntroductionIn the progressive phase of multiple sclerosis (MS), the hampered differentiation capacity of oligodendrocyte precursor cells (OPCs) eventually results in remyelination failure. We have previously shown that DNA methylation ofId2/Id4is hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e91886886523bd2564b11995719c83ae
https://doi.org/10.1101/2023.01.12.523740
https://doi.org/10.1101/2023.01.12.523740
Autor:
Tiane, Assia, Schepers, Melissa, Reijnders, Rick A., Veggel, Lieve Van, Chenine, Sarah, Rombaut, Ben, Dempster, Emma, Verfaillie, Catherine, Wasner, Kobi, Grünewald, Anne, Prickaerts, Jos, Pishva, Ehsan, Hellings, Niels, Hove, Daniel Van Den, Vanmierlo, Tim
Introduction In the progressive phase of multiple sclerosis (MS), the hampered differentiation capacity of oligodendrocyte precursor cells (OPCs) eventually results in remyelination failure. We have previously shown that DNA methylation of Id2/Id4 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2658::757caf6952bd0984bd197044e9e5fae2
http://orbilu.uni.lu/handle/10993/55270
http://orbilu.uni.lu/handle/10993/55270
Autor:
Karolina Pavic, Nikhil Gupta, Judit Domènech Omella, Rita Derua, Anna Aakula, Riikka Huhtaniemi, Juha A. Määttä, Nico Höfflin, Juha Okkeri, Zhizhi Wang, Otto Kauko, Roosa Varjus, Henrik Honkanen, Daniel Abankwa, Maja Köhn, Vesa P. Hytönen, Wenqing Xu, Jakob Nilsson, Rebecca Page, Veerle Janssens, Alexander Leitner, Jukka Westermarck
Publikováno v:
Nature Communications, 14 (1)
Pavic, K, Gupta, N, Omella, J D, Derua, R, Aakula, A, Huhtaniemi, R, Määttä, J A, Höfflin, N, Okkeri, J, Wang, Z, Kauko, O, Varjus, R, Honkanen, H, Abankwa, D, Köhn, M, Hytönen, V P, Xu, W, Nilsson, J, Page, R, Janssens, V, Leitner, A & Westermarck, J 2023, ' Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A ', Nature Communications, vol. 14, 1143 . https://doi.org/10.1038/s41467-023-36693-9
Pavic, K, Gupta, N, Omella, J D, Derua, R, Aakula, A, Huhtaniemi, R, Määttä, J A, Höfflin, N, Okkeri, J, Wang, Z, Kauko, O, Varjus, R, Honkanen, H, Abankwa, D, Köhn, M, Hytönen, V P, Xu, W, Nilsson, J, Page, R, Janssens, V, Leitner, A & Westermarck, J 2023, ' Structural mechanism for inhibition of PP2A-B56α and oncogenicity by CIP2A ', Nature Communications, vol. 14, 1143 . https://doi.org/10.1038/s41467-023-36693-9
The protein phosphatase 2A (PP2A) heterotrimer PP2A-B56α is a human tumour suppressor. However, the molecular mechanisms inhibiting PP2A-B56α in cancer are poorly understood. Here, we report molecular level details and structural mechanisms of PP2A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a638973e7be8ff61baa72320d130abe
https://trepo.tuni.fi/handle/10024/147130
https://trepo.tuni.fi/handle/10024/147130