Zobrazeno 1 - 10
of 572
pro vyhledávání: '"Biophysics and Computational Biology"'
Tissue flow during morphogenesis is commonly driven by local constriction of cell cortices, which is caused by activation of actomyosin contractility. This can lead to long-range flows due to tissue viscosity. However, in the absence of cell-intrinsi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______3430::6a1daf410c2b63700b1692439fbe80be
https://hal.science/hal-03796461
https://hal.science/hal-03796461
Autor:
Dennis A, Hesselink, Karin, Boer
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Hematopoietic cell transplantation is the gold standard treatment for many blood disorders, including blood cancers. Nonetheless, frequent post-transplant complications limit the long-term benefit of HCT. Here, we find that circulating c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc66115af1b47ee959b58159d432ba3b
https://pubmed.ncbi.nlm.nih.gov/35058359
https://pubmed.ncbi.nlm.nih.gov/35058359
Autor:
Nicholas F. Polizzi, Fabio Pirro, Nathan W. Schmidt, Michael J. Therien, Lijun Liu, Marco Chino, Michael Grabe, William F. DeGrado, Angela Lombardi, James Lincoff, Zachary X Widel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 52
Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 52
Significance A major mechanism of evolution involves fusing genes that encode single-domain proteins to create multidomain structures that achieve new functions. Here, we develop methods to design multidomain proteins entirely from scratch and achiev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::051c4ada5e148ffc846505b90f345846
https://doi.org/10.1073/pnas.2017062117
https://doi.org/10.1073/pnas.2017062117
Autor:
Hong-fei Wang, Ethan A. Perets, Daniel Konstantinovsky, Sharon Hammes-Schiffer, Li Fu, Elsa C. Y. Yan, Jiantao Chen
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Biomolecular hydration is fundamental to biological functions. Using phase-resolved chiral sum-frequency generation spectroscopy (SFG), we probe molecular architectures and interactions of water molecules around a self-assembling antiparallel β-shee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac6caf44b298f2050ab2e859ca6f1bd7
https://doi.org/10.1073/pnas.2015567117
https://doi.org/10.1073/pnas.2015567117
Autor:
Herbert Nar, James Hamilton, Florian Binder, Dennis Fiegen, Sven Thamm, Markus Zeeb, James C. King, Margit Bauer, Martin Rübbelke
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance Necroptosis is an emergency controlled cell-death mechanism, which only may be activated in case of impaired apoptosis. Necroptosis leads to unchecked release of proinflammatory cytoplasmatic content of the cells and is thereby implicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b458cb61cb262abaac9298bd16d5bc
https://doi.org/10.1073/pnas.2017406117
https://doi.org/10.1073/pnas.2017406117
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Liquid–liquid phase separation of proteins results in biomolecular condensates, which contribute to the organization of cellular matter into membraneless organelles. It is still unclear, however, whether these condensates represent a c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1f9706d12c6549642ff17a4fd819e58
http://europepmc.org/articles/PMC7777240
http://europepmc.org/articles/PMC7777240
Autor:
Jonas Denk, Erwin Frey
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Propelled agents that align their orientations upon collisions can give rise to macroscopic order. Depending on the details of the agents’ collisions, this ordering process can lead to spatiotemporal patterns, including traveling polar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc48fad3426ba1ecdc9c2800194bd50
https://doi.org/10.1073/pnas.2010302117
https://doi.org/10.1073/pnas.2010302117
Autor:
Hirofumi Morishita, Conor Liston, Mitchell H. Murdock, Cristina Lao-Peregrin, Gregory A. Petsko, Francis S. Lee, Elisa M. Nabel, Benjamin C. Campbell, Pantelis Tsoulfas, Murray Blackmore
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We have developed a fluorescent protein, mGreenLantern, that features exceptionally high brightness in mouse, bacterial, and human cells (up to sixfold brighter than EGFP) and have demonstrated its superior ability to highlight neuronal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7bca5ce728bc3b4f8e66ed9b3b3f27
https://doi.org/10.1073/pnas.2000942117
https://doi.org/10.1073/pnas.2000942117
Autor:
Etana Padan, Ramakanta Mondal, Amit Kessel, Erik Lindahl, Nir Ben-Tal, Abraham Rimon, Gal Masrati
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Membrane-embedded cation/proton antiporters (CPAs) exchange monovalent cations with protons by alternating between two extreme states: inward- and outward-facing. Although atomic-resolution structures are available, there is still an ong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f190c2c36ad1a0067262cfa2580a2453
http://europepmc.org/articles/PMC7749304
http://europepmc.org/articles/PMC7749304
Autor:
Antoine M. van Oijen, Jacob S. Lewis, Stefan H. Mueller, Grant D Schauer, Lisanne M. Spenkelink, Mike O'Donnell, Olga Yurieva
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The replisome machine that duplicates the DNA genome encounters a variety of blocks to replication, such as DNA bound proteins, R-loops, and DNA lesions. Studies in bacterial systems demonstrate that replisome advance through blocks is f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfb793876254c79256aef992d42f822
http://europepmc.org/articles/PMC7720201
http://europepmc.org/articles/PMC7720201