SecM-stalled ribosomes adopt an altered geometry at the peptidyl transferase center

Autor: Birgit Seidelt, Shashi Bhushan, Jens Frauenfeld, Thomas Hoffmann, Thorsten Mielke, Otto Berninghausen, Roland Beckmann, Daniel N. Wilson

Publikováno v: PLoS Biology, Vol 9, Iss 1, p e1000581 (2011)
PLoS Biology

A structure of a ribosome stalled during translation of the SecM peptide provides insight into the mechanism by which the large subunit active site is inactivated.
As nascent polypeptide chains are synthesized, they pass through a tunnel in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24be6da517483871896722bc99e337da
http://europepmc.org/articles/PMC3022528?pdf=render

TRANSAT-- method for detecting the conserved helices of functional RNA structures, including transient, pseudo-knotted and alternative structures

Autor: Nicholas J. P. Wiebe, Irmtraud M. Meyer

Publikováno v: PLoS Computational Biology, Vol 6, Iss 6, p e1000823 (2010)
PLoS Computational Biology

The prediction of functional RNA structures has attracted increased interest, as it allows us to study the potential functional roles of many genes. RNA structure prediction methods, however, assume that there is a unique functional RNA structure and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1135f44d4593f7a750953ec3217c9ce
http://europepmc.org/articles/PMC2891591?pdf=render

Preparation of group I introns for biochemical studies and crystallization assays by native affinity purification

Autor: Luis F. Duarte, Quentin Vicens, Anne R. Gooding, Robert T. Batey

Publikováno v: PLoS ONE, Vol 4, Iss 8, p e6740 (2009)
PLoS ONE

The study of functional RNAs of various sizes and structures requires efficient methods for their synthesis and purification. Here, 23 group I intron variants ranging in length from 246 to 341 nucleotides -- some containing exons -- were subjected to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3e2dc9a4dffed62cd65883663434ff2
http://europepmc.org/articles/PMC2729099?pdf=render

Prediction of RNA Pseudoknots Using Heuristic Modeling with Mapping and Sequential Folding

Autor: Wayne Dawson, Kazuya Fujiwara, Gota Kawai

Publikováno v: PLoS ONE
PLoS ONE, Vol 2, Iss 9, p e905 (2007)

Predicting RNA secondary structure is often the first step to determining the structure of RNA. Prediction approaches have historically avoided searching for pseudoknots because of the extreme combinatorial and time complexity of the problem. Yet neg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5a17d1057cb04d3bf9115eed4709728

A Probabilistic Model of RNA Conformational Space

Autor: Jes Frellsen, Martin Thiim, Kanti V. Mardia, Ida Moltke, Thomas Hamelryck, Jesper Ferkinghoff-Borg

Publikováno v: Frellsen, J, Moltke, I, Thiim, M, Mardia, K V, Ferkinghoff-Borg, J & Hamelryck, T 2009, ' A probabilistic model of RNA conformational space ', PLoS Computational Biology, vol. 5, no. 6, pp. e1000406 . https://doi.org/10.1371/journal.pcbi.1000406
Frellsen, J, Moltke, I, Thiim, M, Mardia, K, Ferkinghoff-Borg, J & Hamelryck, T 2009, ' A probabilistic model of RNA conformational space ', P L o S Computational Biology (Online), vol. 5, no. 6, pp. e1000406 . https://doi.org/10.1371/journal.pcbi.1000406
PLoS Computational Biology
PLoS Computational Biology, Vol 5, Iss 6, p e1000406 (2009)

The increasing importance of non-coding RNA in biology and medicine has led to a growing interest in the problem of RNA 3-D structure prediction. As is the case for proteins, RNA 3-D structure prediction methods require two key ingredients: an accura

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7941f4c330daa16cb55f749b0beef95
https://doi.org/10.1371/journal.pcbi.1000406