Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Biophysics/Biocatalysis"'
Autor:
Jiahai Shi, Shixiong Lua, Yuguang Mu, Lushan Wang, Nanyu Han, Liangzhong Lim, J. Sivaraman, Jianxing Song
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, Vol 7, Iss 2, p e1001084 (2011)
PLoS Computational Biology, Vol 7, Iss 2, p e1001084 (2011)
Despite utilizing the same chymotrypsin fold to host the catalytic machinery, coronavirus 3C-like proteases (3CLpro) noticeably differ from picornavirus 3C proteases in acquiring an extra helical domain in evolution. Previously, the extra domain was
Publikováno v:
PLoS Computational Biology, Vol 6, Iss 11, p e1000978 (2010)
PLoS Computational Biology
Buslje, C M, Teppa, E, Di Doménico, T, Delfino, J M & Nielsen, M 2010, ' Networks of High Mutual Information Define the Structural Proximity of Catalytic Sites: Implications for Catalytic Residue Identification ', P L o S Computational Biology (Online), vol. 6, no. 11 . https://doi.org/10.1371/journal.pcbi.1000978
Scopus-Elsevier
PLoS Computational Biology
Buslje, C M, Teppa, E, Di Doménico, T, Delfino, J M & Nielsen, M 2010, ' Networks of High Mutual Information Define the Structural Proximity of Catalytic Sites: Implications for Catalytic Residue Identification ', P L o S Computational Biology (Online), vol. 6, no. 11 . https://doi.org/10.1371/journal.pcbi.1000978
Scopus-Elsevier
Identification of catalytic residues (CR) is essential for the characterization of enzyme function. CR are, in general, conserved and located in the functional site of a protein in order to attain their function. However, many non-catalytic residues
Autor:
Nicastro, G., Todi, S. V., Karaca, E., Bonvin, A.M.J.J., Paulson, H. L., Pastore, A., NMR Spectroscopy, Sub NMR Spectroscopy
Publikováno v:
PLoS ONE
PLoS One, 5(8), e12430/1. Public Library of Science
PLoS ONE, Vol 5, Iss 8, p e12430 (2010)
PLoS One, 5(8), e12430/1. Public Library of Science
PLoS ONE, Vol 5, Iss 8, p e12430 (2010)
Ataxin-3, the disease protein in the neurodegenerative disorder Spinocerebellar Ataxia Type 3 or Machado Joseph disease, is a cysteine protease implicated in the ubiquitin proteasome pathway. It contains multiple ubiquitin binding sites through which
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12026 (2010)
PLoS ONE, Vol 5, Iss 8, p e12026 (2010)
Background Bisubstrate enzymes, such as 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1), exist in solution as an ensemble of conformations. 17beta-HSD1 catalyzes the last step of the biosynthesis of estradiol and, thus, it is a potentially a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da661a278ab1932c5a627227e106dbf8
http://hdl.handle.net/11585/90948
http://hdl.handle.net/11585/90948
Autor:
Fabien Giroud, Aymeric Pellissier, Philippe Cinquin, Simon Mazabrard, Serge Cosnier, Jean-Pierre Alcaraz, Chantal Gondran, Paolo Porcu, Karine Gorgy, François Lenouvel, Stephane Mathe, François Boucher
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2010, 5 (5), pp.e10476. ⟨10.1371/journal.pone.0010476⟩
PLoS ONE, Vol 5, Iss 5, p e10476 (2010)
PLoS ONE, 2010, 5 (5), pp.e10476. ⟨10.1371/journal.pone.0010476⟩
PLoS ONE, Public Library of Science, 2010, 5 (5), pp.e10476. ⟨10.1371/journal.pone.0010476⟩
PLoS ONE, Vol 5, Iss 5, p e10476 (2010)
PLoS ONE, 2010, 5 (5), pp.e10476. ⟨10.1371/journal.pone.0010476⟩
International audience; Powering future generations of implanted medical devices will require cumbersome transcutaneous energy transfer or harvesting energy from the human body. No functional solution that harvests power from the body is currently av
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58a9b70d4ec90dfbc1e822cc72d783b8
https://hal.archives-ouvertes.fr/hal-00688232
https://hal.archives-ouvertes.fr/hal-00688232
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6740 (2009)
PLoS ONE
PLoS ONE
The study of functional RNAs of various sizes and structures requires efficient methods for their synthesis and purification. Here, 23 group I intron variants ranging in length from 246 to 341 nucleotides -- some containing exons -- were subjected to
Publikováno v:
PLoS ONE
PLoS ONE, Vol 4, Iss 5, p e5736 (2009)
PLoS ONE, Vol 4, Iss 5, p e5736 (2009)
Background: The members of cupin superfamily exhibit large variations in their sequences, functions, organization of domains, quaternary associations and the nature of bound metal ion, despite having a conserved beta-barrel structural scaffold. Here,
Publikováno v:
Aranko, A S, Züger, S, Buchinger, E & Iwai, H 2009, ' In Vivo and In Vitro Protein Ligation by Naturally Occurring and Engineered Split DnaE Inteins ', PLOS ONE, vol. 4, no. 4, pp. e5185 .
PLoS ONE
PLoS ONE, Vol 4, Iss 4, p e5185 (2009)
PLoS ONE
PLoS ONE, Vol 4, Iss 4, p e5185 (2009)
BACKGROUND: Protein trans-splicing by naturally occurring split DnaE inteins is used for protein ligation of foreign peptide fragments. In order to widen biotechnological applications of protein trans-splicing, it is highly desirable to have split in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::722d238acfaa4e7143196d05eac3ef82
https://vbn.aau.dk/da/publications/9a7a9e30-3570-11de-8a17-000ea68e967b
https://vbn.aau.dk/da/publications/9a7a9e30-3570-11de-8a17-000ea68e967b
Publikováno v:
PLoS ONE
PLoS ONE, Vol 4, Iss 6, p e5773 (2009)
PLoS ONE, Vol 4, Iss 6, p e5773 (2009)
The origin of the genetic code in the context of an RNA world is a major problem in the field of biophysical chemistry. In this paper, we describe how the polymerization of amino acids along RNA templates can be affected by the properties of both mol
Autor:
Jeffrey J. Gray, Michael D. Daily
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 2, p e1000293 (2009)
PLoS Computational Biology
PLoS Computational Biology
Allosteric proteins bind an effector molecule at one site resulting in a functional change at a second site. We hypothesize that allosteric communication in proteins relies upon networks of quaternary (collective, rigid-body) and tertiary (residue–