Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Evaluation of drug permeability methods recommended by health authorities

Autor: Tugba Gulsun, Selma Sahin

Publikováno v: Medicine Science, Vol 9, Iss 1, Pp 261-4 (2020)

The oral route is the most preferred route for drug administration because of patient compliance. Following oral administration, a drug has to cross several biological barriers before reaching the systemic circulation by transcellular or paracellular

Externí odkaz: https://doaj.org/article/47f52cb8bba641dfab9cc1dc63420c81

Exploring a Bioequivalence Failure for Silodosin Products Due to Disintegrant Excipients

Autor: Isabel González-Álvarez, Bárbara Sánchez-Dengra, Raquel Rodriguez-Galvez, Alejandro Ruiz-Picazo, Marta González-Álvarez, Alfredo García-Arieta, Marival Bermejo

Publikováno v: Pharmaceutics, Vol 14, Iss 12, p 2565 (2022)

Some years ago, excipients were considered inert substances irrelevant in the absorption process. However, years of study have demonstrated that this belief is not always true. In this study, the reasons for a bioequivalence failure between two formu

Externí odkaz: https://doaj.org/article/c59935dd1d544a3f870878e72c51ca57

Investigation of biopharmaceutical and physicochemical drug properties suitable for orally disintegrating tablets

Autor: Asami Ono, Takumi Tomono, Takuo Ogihara, Katsuhide Terada, Kiyohiko Sugano

Publikováno v: ADMET and DMPK, Vol 4, Iss 4, Pp 335-360 (2016)

The purpose of this study was to evaluate the biopharmaceutical drug properties suitable for orally disintegrating tablets (ODTs). The net charge at pH 7.4, log D6.5, the highest dose strength, solubility in water, dose number, and elimination t1/2 o

Externí odkaz: https://doaj.org/article/a5de67cc30c04837a2881b1060b12693

Investigating the Critical Variables of Azithromycin Oral Absorption Using In Vitro Tests and PBPK Modeling

Autor: Maria Vertzoni, Pascal Somville, Mariana Guimarães, Nikoletta Fotaki

Publikováno v: Guimaraes Sa Correia, M, Somville, P, Vertzoni, M & Fotaki, N 2021, ' Investigating the critical variables of azithromycin oral absorption using in vitro tests and PBPK Modeling ', Journal of Pharmaceutical Sciences, vol. 110, no. 12, pp. 3874-3888 . https://doi.org/10.1016/j.xphs.2021.09.013

Azithromycin is an antibiotic listed in the essential list of medicines for adults and pediatrics. Conflicting evidence has been found regarding azithromycin classification according to the Biopharmaceutics classification system (BCS). The purpose of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98589c7e0f4fad2e33d8dde50a0ff70f
https://doi.org/10.1016/j.xphs.2021.09.013