Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Biology of Aging: Interventions"'
Publikováno v:
Innovation in Aging
Exercise is beneficial for physical functions across all ages. However, the response to exercise shifts from anabolism, resulting in limited gain of muscle strength and endurance. These changes likely reflect age-related alterations in transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bae91855dc473934fdafec852642b18b
https://doi.org/10.1093/geroni/igab046.2554
https://doi.org/10.1093/geroni/igab046.2554
Autor:
Carlos Isales, Ke-Hong Ding, Wendy Bollag, Meghan McGee-Lawrence, William Hill, Xing-ming Shi, Sadanand Fulzele, Mark Hamrick
Publikováno v:
Innovation in Aging
Aging is associated with accumulation of various tryptophan degradation products that may having either bone anabolic or catabolic effects. In epidemiologic studies, elevated levels of 3-hydroxyanthranilic acid (3-HAA) are associated with a higher bo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cafdb05710527bbec27d4d6b28ef774
http://europepmc.org/articles/PMC8681452
http://europepmc.org/articles/PMC8681452
Autor:
Castro-Portuguez, Raul, Meyers, Jeremy, Freitas, Sam, Dang, Hope, Turner, Emily, DeNicola, Destiny, Espejo, Luis, Sutphin, George
Publikováno v:
Innovation in Aging
Aging is characterized by a progressive decline in the normal physiological functions of an organism, ultimately leading to mortality. Metabolic changes throughout the aging process disrupt the balance and homeostasis of the cell. The kynurenine meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::025423603971ab08d9729846274009f9
https://doi.org/10.1093/geroni/igab046.2557
https://doi.org/10.1093/geroni/igab046.2557
Publikováno v:
Innovation in Aging
To assess the differential effects of exercise with age, Young (Y, 10-12 weeks) and Old (O, 23-25 months) mice were subjected to regimented treadmill running or no regimented exercise. Y, trained mice experienced a significant increase in maximal dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::065e87abf4d2aa8a0eea1b7082b1a608
http://europepmc.org/articles/PMC8680761
http://europepmc.org/articles/PMC8680761
Autor:
Ken Seldeen, Ramkumar Thiyagarajan, Merced Leiker, Reem Berman, Yonas Redae, Carleara Weiss, Lee Chaves, Bruce Troen
Publikováno v:
Innovation in Aging
Frailty is a condition of poor response to stressors that increases susceptibility to adverse outcomes - including disability and death. Declining physical function is an important hallmark of frailty, and we previously published that long term vitam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070393ea25d82e78daf730a1423bfa0c
http://europepmc.org/articles/PMC8681264
http://europepmc.org/articles/PMC8681264
Publikováno v:
Innovation in Aging
Preclinical exercise studies typically use two forms of exercise training protocols: 1) voluntary wheel running and 2) forced treadmill running. Previous work from our group clearly demonstrates that older (18-month-old) male mice do not voluntarily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf779753a10003044a021485f8f3aad
https://doi.org/10.1093/geroni/igab046.2570
https://doi.org/10.1093/geroni/igab046.2570
Autor:
George Sutphin, Hope Dang, Luis Espejo, Raul Castro-Portuguez, Bradford Hull, Jeremy Meyers, Emily Turner, Destiny DeNicola
Publikováno v:
Innovation in Aging
Aberrant kynurenine pathway metabolism is increasingly linked to aging and age-associated disease. Kynurenine metabolic activity increases with age and becomes dysregulated during various forms of age-associated pathology in humans. By manipulating o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3b98194a28abef5315b36cd7c730a2c
http://europepmc.org/articles/PMC8680976
http://europepmc.org/articles/PMC8680976
Autor:
Zhang, Lei, Hughes, Brian, Angelini, Luise, O’Kelly, Ryan, Yousefzadeh, Matthew, Kamenecka, Ted, Niedernhofer, Laura, Robbins, Paul
Publikováno v:
Innovation in Aging
Senescent cells accumulate with age in various tissues and organs, leading to the decline in tissue function and deterioration of many age-related diseases and aging. Senolytics have emerged as an effective therapeutic approach to eliminate senescent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d367caeef98037c8a63a75154ec9ecc
https://doi.org/10.1093/geroni/igab046.2564
https://doi.org/10.1093/geroni/igab046.2564
The relationship between physical activity intensity and volume on prospective falls in older adults
Publikováno v:
Innovation in Aging
The benefits of Physical Activity (PA) for older adults have been well documented relative to several physiological and neuromuscular factors, but the direct relationship of PA to fall incidence is unclear. In particular, the influence of the intensi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792aaa786352f4eca90bf50e0c98538d
https://doi.org/10.1093/geroni/igab046.2568
https://doi.org/10.1093/geroni/igab046.2568
Autor:
Marin, Sela, Nidadavolu, Lolita S, Walston, Jeremy D, Gilkes, Daniele, Abadir, Peter M, Godet, Ines
Publikováno v:
Innovation in Aging
Collagen is a major component of the skin’s support system, allowing for firmness, elasticity, and mechanical strength. In older adults, skin collagen production decreases significantly, and is associated with increased sagging, wrinkling, and thin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c30f60ebf9b4cb23a1bf26e4555b92
https://doi.org/10.1093/geroni/igab046.2571
https://doi.org/10.1093/geroni/igab046.2571