Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Biology experimental methods"'
Autor:
Signe Adamberg, Torben Sølbeck Rasmussen, Sabina Brigitte Larsen, Xiaotian Mao, Dennis Sandris Nielsen, Kaarel Adamberg
Publikováno v:
iScience, Vol 27, Iss 8, Pp 110460- (2024)
Summary: Recent studies indicate an important role of bacteriophages for successful fecal microbiota transplantation (FMT). However, wider clinical applications of FMT are hampered by to donor variability and concerns of infection risks by bacteria a
Externí odkaz:
https://doaj.org/article/1500aafb3aee4b789eb1e93665b01f0c
Autor:
Romina J. Bevacqua, Weichen Zhao, Emilio Merheb, Seung Hyun Kim, Alexander Marson, Anna L. Gloyn, Seung K. Kim
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108693- (2024)
Summary: Successful genome editing in primary human islets could reveal features of the genetic regulatory landscape underlying β cell function and diabetes risk. Here, we describe a CRISPR-based strategy to interrogate functions of predicted regula
Externí odkaz:
https://doaj.org/article/de99b45ae5104da68c614e2231a5ccff
Autor:
Collyn M. Kellogg, Kevin Pham, Sunghwan Ko, Jillian E.J. Cox, Adeline H. Machalinski, Michael B. Stout, Amanda L. Sharpe, Michael J. Beckstead, Ana J. Chucair-Elliott, Sarah R. Ocañas, Willard M. Freeman
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108413- (2023)
Summary: Temporally controlling Cre recombination through tamoxifen (Tam) induction has many advantages for biomedical research. Most studies report early post-natal/juvenile (12 m.o.). While anecdotally reported as problematic, there are no publishe
Externí odkaz:
https://doaj.org/article/efa2f29c8faf4f80b3c9fffa0d593cbf
Autor:
Deronisha Arceneaux, Zhengyi Chen, Alan J. Simmons, Cody N. Heiser, Austin N. Southard-Smith, Michael J. Brenan, Yilin Yang, Bob Chen, Yanwen Xu, Eunyoung Choi, Joshua D. Campbell, Qi Liu, Ken S. Lau
Publikováno v:
iScience, Vol 26, Iss 7, Pp 107242- (2023)
Summary: Droplet-based single-cell RNA-seq (scRNA-seq) data are plagued by ambient contaminations caused by nucleic acid material released by dead and dying cells. This material is mixed into the buffer and is co-encapsulated with cells, leading to a
Externí odkaz:
https://doaj.org/article/023e2b611ee743e9a29a87c90b558a38
Publikováno v:
iScience, Vol 26, Iss 1, Pp 105796- (2023)
Summary: To use regeneratively active cells for cell therapeutic applications, the cells must be isolated from their resident tissues. Different isolation procedures subject these cells to varying degrees of mechanical strain, which can affect the yi
Externí odkaz:
https://doaj.org/article/833ca64bc6f1424abb6a6161421e117c
Autor:
Nan An, Fuzhi Cao, Wen Li, Wenli Wang, Weinan Xu, Chunhui Wang, Min Xiang, Yang Gao, Binbin Sui, Dawei Wang, Dexin Yu, Xiaolin Ning
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105177- (2022)
Summary: The emergence of the optically pumped magnetometer (OPM)-based magnetoencephalography (MEG) has led to new developments in MEG technology. The source imaging results of different magnetic source imaging (MSI) methods show considerable differ
Externí odkaz:
https://doaj.org/article/e93892c3f1244b04bd5d6ad07229ea0a
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105046- (2022)
Summary: Cell-free DNA (cfDNA) has become the predominant analyte of liquid biopsy; however, recent studies suggest the presence of subnucleosomal-sized DNA fragments in circulation that are likely single-stranded. Here, we report a method called dir
Externí odkaz:
https://doaj.org/article/43d6c0b12503424abaa9c7b457a5e6b6
Autor:
Tanveer Teranikar, Cameron Villarreal, Nabid Salehin, Toluwani Ijaseun, Jessica Lim, Cynthia Dominguez, Vivian Nguyen, Hung Cao, Cheng–Jen Chuong, Juhyun Lee
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104876- (2022)
Summary: In vivo quantitative assessment of structural and functional biomarkers is essential for characterizing the pathophysiology of congenital disorders. In this regard, fixed tissue analysis has offered revolutionary insights into the underlying
Externí odkaz:
https://doaj.org/article/1bb96940588141d3a765a8506a1d736c
Autor:
Shuangyi Cai, Thomas Hu, Mythreye Venkatesan, Mayar Allam, Frank Schneider, Suresh S. Ramalingam, Shi-Yong Sun, Ahmet F. Coskun
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104980- (2022)
Summary: Protein-protein interaction networks are altered in multi-gene dysregulations in many disorders. Image-based protein multiplexing sheds light on signaling pathways to dissect cell-to-cell heterogeneity, previously masked by the bulk assays.
Externí odkaz:
https://doaj.org/article/2973f78274a64a138c9d983aadb5dd2c
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