Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Biola-Maria Javierre"'
Autor:
Stephen Watt, Louella Vasquez, Klaudia Walter, Alice L. Mann, Kousik Kundu, Lu Chen, Ying Sims, Simone Ecker, Frances Burden, Samantha Farrow, Ben Farr, Valentina Iotchkova, Heather Elding, Daniel Mead, Manuel Tardaguila, Hannes Ponstingl, David Richardson, Avik Datta, Paul Flicek, Laura Clarke, Kate Downes, Tomi Pastinen, Peter Fraser, Mattia Frontini, Biola-Maria Javierre, Mikhail Spivakov, Nicole Soranzo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
PU.1 is a master regulator of myeloid development but its role in disease-relevant neutrophils is not well known. Here, the authors look at primary neutrophils from a human population and find that genetic variants affecting binding of PU.1 are assoc
Externí odkaz:
https://doaj.org/article/a08e861a297c4eba8c835747ae9b90f8
Autor:
Clara Lopes Novo, Biola-Maria Javierre, Jonathan Cairns, Anne Segonds-Pichon, Steven W. Wingett, Paula Freire-Pritchett, Mayra Furlan-Magaril, Stefan Schoenfelder, Peter Fraser, Peter J. Rugg-Gunn
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2615-2627 (2018)
Summary: Transcriptional enhancers, including super-enhancers (SEs), form physical interactions with promoters to regulate cell-type-specific gene expression. SEs are characterized by high transcription factor occupancy and large domains of active ch
Externí odkaz:
https://doaj.org/article/a9fe24befd3e4a119da1557f07e1eacc
Autor:
Oliver S. Burren, Arcadio Rubio García, Biola-Maria Javierre, Daniel B. Rainbow, Jonathan Cairns, Nicholas J. Cooper, John J. Lambourne, Ellen Schofield, Xaquin Castro Dopico, Ricardo C. Ferreira, Richard Coulson, Frances Burden, Sophia P. Rowlston, Kate Downes, Steven W. Wingett, Mattia Frontini, Willem H. Ouwehand, Peter Fraser, Mikhail Spivakov, John A. Todd, Linda S. Wicker, Antony J. Cutler, Chris Wallace
Publikováno v:
Genome Biology, Vol 18, Iss 1, Pp 1-19 (2017)
Abstract Background Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates iden
Externí odkaz:
https://doaj.org/article/a2ac010742a3449aa23a667a36cbedcf
Autor:
Hannes Ponstingl, Simone Ecker, Manuel Tardaguila, Samantha Farrow, Paul Flicek, Valentina Iotchkova, Ben Farr, Mattia Frontini, Lu Chen, Nicole Soranzo, Louella Vasquez, Peter Fraser, David J. Richardson, Alice L. Mann, Avik Datta, Daniel Mead, Heather Elding, Kate Downes, Klaudia Walter, Tomi Pastinen, Kousik Kundu, Biola-Maria Javierre, Mikhail Spivakov, Ying Sims, Stephen Watt, Frances Burden, Laura Clarke
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Nature Communications
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Funder: MS is funded by Medical Research Council (MC-A652-5QA20)
Funder: This work was supported by the Wellcome Trust grant (206194) and EU FP7 High Impact Project BLUEPRINT (HEALTH-F5-2011-282510)
Neutrophils play fundamental roles in inn
Funder: This work was supported by the Wellcome Trust grant (206194) and EU FP7 High Impact Project BLUEPRINT (HEALTH-F5-2011-282510)
Neutrophils play fundamental roles in inn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f7887c9ca8ee974997e8746c21faa42
https://www.repository.cam.ac.uk/handle/1810/323446
https://www.repository.cam.ac.uk/handle/1810/323446
Autor:
Peter Fraser, Biola-Maria Javierre, Mayra Furlan-Magaril, Stefan Schoenfelder, Steven W. Wingett
Publikováno v:
Journal of Visualized Experiments : JoVE
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
The three-dimensional organization of the genome is linked to its function. For example, regulatory elements such as transcriptional enhancers control the spatio-temporal expression of their target genes through physical contact, often bridging consi
Autor:
Steven W. Wingett, Peter Fraser, Anne Segonds-Pichon, Paula Freire-Pritchett, Stefan Schoenfelder, Biola-Maria Javierre, Jonathan Cairns, Peter J. Rugg-Gunn, Clara Lopes Novo, Mayra Furlan-Magaril
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2615-2627 (2018)
Cell Reports
Cell Reports
Summary Transcriptional enhancers, including super-enhancers (SEs), form physical interactions with promoters to regulate cell-type-specific gene expression. SEs are characterized by high transcription factor occupancy and large domains of active chr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cfaf4bf0e7e0cf324a63be935f4badd
Autor:
Henk Stunnenberg, Cutler A, Ivliev A, Lancashire L, Mattia Frontini, Simon Heath, Stephan Beck, Wallace C, Steven W. Wingett, Peter Fraser, Kate Downes, Biola-Maria Javierre, Emanuele Libertini, Garcia Ar, Martens Jha, Gut M, Luigi Grassi, Debjani Paul, Jonathan Cairns, Willem H. Ouwehand, Gut I, Mikhail Spivakov, Rifat Hamoudi
Understanding the regulatory landscape of human cells requires the integration of genomic and epigenomic maps, capturing combinatorial levels of cell type-specific and invariant activity states.Here, we segmented whole-genome bisulfite sequencing-der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d15c1953d88e83e62396b3904d320bc
The International Human Epigenome Consortium: A Blueprint for Scientific Collaboration and Discovery
Autor:
Sergio Abrignani, David Adams, Melanie de Almeida, ALTUCCI, Lucia, Viren Amin, Ido Amit, Stylianos E, Antonarakis, Samuel Aparicio, Takahiro Arima, Laura Arrigoni, Rob Arts, Vahid Asnafi, Manel Esteller, Jae Bum Bae, Kevin Bassler, Stephan Beck, Benjamin Berkman, Bradley E, Bernstein, Mikhail Bilenky, Adrian Bird, Christoph Bock, Bernhard Boehm, Guillaume Bourque, Charles E, Breeze, Benedikt Brors, David Bujold, Oliver Burren, Marion J, Bussemakers, Adam Butterworth, Elias Campo, Enrique Carrillo de Santa Pau, Lisa Chadwick, Kui Ming Chan, Wei Chen, Tom H, Cheung, Luca Chiapperino, Nak Hyen Choi, Ho Ryun Chung, Laura Clarke, Joseph M, Connors, Philippe Cronet, John Danesh, Manolis Dermitzakis, Gerard Drewes, Pawel Durek, Stephanie Dyke, Tomasz Dylag, Connie J, Eaves, Peter Ebert, Roland Eils, Jürgen Eils, Catherine A, Ennis, Tariq Enver, Elise A, Feingold, Bärbel Felder, Anne Ferguson Smith, Jude Fitzgibbon, Paul Flicek, Roger S, Y, Foo, Peter Fraser, Mattia Frontini, Eileen Furlong, Sitanshu Gakkhar, Nina Gasparoni, Gilles Gasparoni, Daniel H, Geschwind, Petar Glažar, Thomas Graf, Frank Grosveld, Xin Yuan Guan, Roderic Guigo, Ivo G, Gut, Alf Hamann, Bok Ghee Han, R, Alan Harris, Simon Heath, Kristian Helin, Jan G, Hengstler, Alireza Heravi Moussavi, Karl Herrup, Steven Hill, Jason A, Hilton, Benjamin C, Hitz, Bernhard Horsthemke, Ming Hu, Joo Yeon Hwang, Nancy Y, Takashi Ito, Biola Maria Javierre, Sasa Jenko, Thomas Jenuwein, Yann Joly, Steven J, M, Jones, Yae Kanai, Hee Gyung Kang, Aly Karsan, Alexandra K, Kiemer, Song Cheol Kim, Bong Jo Kim, Hyeon Hoe Kim, Hiroshi Kimura, Sarah Kinkley, Filippos Klironomos, In Uk Koh, Myrto Kostadima, Christopher Kressler, Roman Kreuzhuber, Anshul Kundaje, Ralf Küppers, Carolyn Larabell, Paul Lasko, Mark Lathrop, S, Lee, Suman Lee, Hans Lehrach, Elsa Leitão, Thomas Lengauer, Åke Lernmark, David Leslie, Gilberto K, K, Leung, Danny Leung, Markus Loeffler, Yussanne Ma, Antonello Mai, Thomas Manke, Eric R, Marcotte, Marco A, Marra, Joost H, A, Martens, Jose Ignacio Martin Subero, Karen Maschke, Christoph Merten, Aleksandar Milosavljevic, Saverio Minucci, Totai Mitsuyama, Richard A, Moore, Fabian Müller, Andrew J, Mungall, Mihai G, Netea, Karl Nordström, Irene Norstedt, Hiroaki Okae, Vitor Onuchic, Francis Ouellette, Willem Ouwehand, Massimiliano Pagani, Vera Pancaldi, Thomas Pap, Tomi Pastinen, Ronak Patel, Dirk S, Paul, Michael J, Pazin, Pier Giuseppe Pelicci, Anthony G, Phillips, Julia Polansky, Bo Porse, J, Andrew Pospisilik, Shyam Prabhakar, Dena C, Procaccini, Andreas Radbruch, Nikolaus Rajewsky, Vardham Rakyan, Wolf Reik, Bing Ren, David Richardson, Andreas Richter, Daniel Rico, David J, Roberts, Philip Rosenstiel, Mark Rothstein, Abdulrahman Salhab, Hiroyuki Sasaki, John S, Satterlee, Sascha Sauer, Claudia Schacht, Florian Schmidt, Gerd Schmitz, Stefan Schreiber, Christopher Schröder, Dirk Schübeler, Joachim L, Schultze, Ronald P, Schulyer, Marcel Schulz, Martin Seifert, Katsuhiko Shirahige, Reiner Siebert, Thomas Sierocinski, Laura Siminoff, Anupam Sinha, Nicole Soranzo, Salvatore Spicuglia, Mikhail Spivakov, Christian Steidl, Seth Strattan, Michael Stratton, Peter Südbeck, Hao Sun, Narumi Suzuki, Yutaka Suzuki, Amos Tanay, David Torrents, Frederick L, Tyson, Thomas Ulas, Sebastian Ullrich, Toshikazu Ushijima, Alfonso Valencia, Edo Vellenga, Martin Vingron, Chris Wallace, Stefan Wallner, Jörn Walter, Huating Wang, Stephanie Weber, Nina Weiler, Andreas Weller, Andrew Weng, Steven Wilder, Sam M, Wiseman, Angela R, Zhenguo Wu, Jieyi Xiong, Yasuhiro Yamashita, Xinyi Yang, Desmond Y, Yap, Kevin Y, Yip, Stephen Yip, Jae Il Yoo, Daniel Zerbino, Gideon Zipprich
Publikováno v:
Cell, Vol. 167, No 5 (2016) pp. 1145-1149
Cell, 167, 1145-1149
Cell
Cell, 2016, 167 (5), pp.1145--1149. ⟨10.1016/j.cell.2016.11.007⟩
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Cell, 167, 5, pp. 1145-1149
Cell, 167, 1145-1149
Cell
Cell, 2016, 167 (5), pp.1145--1149. ⟨10.1016/j.cell.2016.11.007⟩
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Cell, 167, 5, pp. 1145-1149
Item does not contain fulltext The International Human Epigenome Consortium (IHEC) coordinates the generation of a catalog of high-resolution reference epigenomes of major primary human cell types. The studies now presented (see the Cell Press IHEC w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::845e48803a7d1e4ee8470ca376fb77af
https://archive-ouverte.unige.ch/unige:90729
https://archive-ouverte.unige.ch/unige:90729
Autor:
Ricardo C. Ferreira, Oliver S. Burren, Xaquin Castro Dopico, John J. Lambourne, Kate Downes, Steven W. Wingett, Mikhail Spivakov, Daniel B. Rainbow, Antony J. Cutler, Ellen Schofield, Linda S. Wicker, Nicholas J. Cooper, Jonathan Cairns, Frances Burden, Richard M.R. Coulson, Mattia Frontini, John A. Todd, Sophia Rowlston, Chris Wallace, Biola-Maria Javierre, Willem H. Ouwehand, Arcadio Rubio García, Peter Fraser
Publikováno v:
Genome Biology
Genome Biology, Vol 18, Iss 1, Pp 1-19 (2017)
Genome Biology, Vol 18, Iss 1, Pp 1-19 (2017)
BackgroundAutoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates identification
Autor:
Kerstin Bystricky, Stephen G. Oliver, Sven Sewitz, Karen Lipkow, Simon Andrews, Latifa Aljebali, Steven W. Wingett, Hicham Saad, Hua Wong, Isabelle Goiffon, Jeremy Bancroft, Csilla Várnai, Otávio J. B. Brustolini, Biola-Maria Javierre, Zahra Fahmi, Stefan Schoenfelder, Peter Fraser
Spatial organisation of the genome is essential for regulating gene activity, yet the mechanisms that shape this three-dimensional organisation in eukaryotes are far from understood. Here, we combine bioinformatic determination of chromatin states du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07a8dbd6564b6df7126ac5eee09545b