Výsledky vyhledávání

Dissertation/ Thesis

Determining neighbouring aminoacids impact on protein sequencing with nanopores using Molecular Dynamics

Autor: Freedman, Victor

One focus goal that science always works towards is an understanding of biological structures, with proteins being one of the main research goals. Sequencing proteins is currently a time-exhausting task, so focus is being put on trying to use nanopor

Externí odkaz: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-531502

Zobrazit plný text záznamu

Dissertation/ Thesis

Water and Ions Dynamics in Modified Hydrophobic Si3N4 Nanopores for Protein Sequencing

Autor: Tabasso, Fabrizio

This thesis presents a computational study of water and ion dynamics in modified hydrophobic silicon nitride (Si3N4) nanopores, aimed at enhancing protein sequenc- ing technologies. By employing molecular dynamics (MD) simulations, the research inves

Externí odkaz: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-533469

Zobrazit plný text záznamu

Dissertation/ Thesis

Molecular Dynamics Simulations of Water Encapsulated Proteins : An investigation of energy and orientability of gas-phase biomolecules in electric fields

Autor: Jakobsson, Ellen

Recent developments in x-ray single particle imaging and diffraction pattern analysis would benefit if the analysis can be made easier and less computationally costly. One way of doing this is to control the orientation of the sample molecules. There

Externí odkaz: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-533712

Zobrazit plný text záznamu

Dissertation/ Thesis

Inducing high Z atoms into DNA to enhance radiation damage - a fragmentation study using first principle simulations

Autor: Rydgren, Brian

Existing cancer treatments, while perhaps proving effective in being destructive of tumours, can also cause significant damage to surrounding healthy tissue. This can cause severe side effects which one would wish to avoid. In order to improve the lo

Externí odkaz: http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-531030

Zobrazit plný text záznamu

Nonionic Surfactants can Modify the Thermal Stability of Globular and Membrane Proteins Interfering with the Thermal Proteome Profiling Principles to Identify Protein Targets

Autor: Emmanuel Berlin, Veronica Lizano-Fallas, Ana Carrasco del Amor, Olatz Fresnedo, Susana Cristobal

Publikováno v: Analytical Chemistry. 95:4033-4042

The membrane proteins are essential targets for understanding cellular function. The unbiased identification of membrane protein targets is still the bottleneck for a system-level understanding of cellular response to stimuli or perturbations. It has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5695ddfa3ab9fa6173e125f05dc4027a
https://doi.org/10.1021/acs.analchem.2c04500

Zobrazit plný text záznamu

Dissertation/ Thesis

Approaches to Structural Characterization of a Heteromeric GABA(A)R

Autor: Stevens, Alexander

Structural biology has become an important part of researching various diseases and drug development. In this thesis, I provide details on how I worked with approaches to structural characterization of a heteromeric GABA(A)R. These pentameric ligand

Externí odkaz: http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-323235

Zobrazit plný text záznamu

Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization

Publikováno v: Sahin, C, Østerlund, E C, Österlund, N, Costeira-Paulo, J, Pedersen, J N, Christiansen, G, Nielsen, J, Grønnemose, A L, Amstrup, S K, Tiwari, M K, Rao, R S P, Bjerrum, M J, Ilag, L L, Davies, M J, Marklund, E G, Pedersen, J S, Landreh, M, Møller, I M, Jørgensen, T J D & Otzen, D E 2022, ' Structural Basis for Dityrosine-Mediated Inhibition of α-Synuclein Fibrillization ', Journal of the American Chemical Society, vol. 144, no. 27, pp. 11949-11954 . https://doi.org/10.1021/jacs.2c03607
Sahin, C, Osterlund, E C, Osterlund, N, Costeira-Paulo, J, Pedersen, J N, Christiansen, G, Nielsen, J, Grønnemose, A L, Amstrup, S K, Tiwari, M K, Rao, R S P, Bjerrum, M J, Ilag, L L, Davies, M J, Marklund, E G, Pedersen, J S, Landreh, M, Moller, I M, Jorgensen, T J D & Otzen, D E 2022, ' Structural Basis for Dityrosine-Mediated Inhibition of alpha-Synuclein Fibrillization ', Journal of the American Chemical Society, vol. 144, no. 27, pp. 11949-11954 . https://doi.org/10.1021/jacs.2c03607

alpha-Synuclein (alpha-Syn) is an intrinsically disordered protein which self-assembles into highly organized beta-sheet structures that accumulate in plaques in brains of Parkinson's disease patients. Oxidative stress influences alpha-Syn structure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a12848347027ec45af73136d3afcb59
https://doi.org/10.1021/jacs.2c03607

Zobrazit plný text záznamu

Unveiling molecular interactions that stabilize bacterial adhesion pili

Autor: Tobias Dahlberg, Joseph L. Baker, Esther Bullitt, Magnus Andersson

Publikováno v: Biophysical Journal. 121:2096-2106

Adhesion pili assembled by the chaperone-usher pathway are superelastic helical filaments on the surface of bacteria, optimized for attachment to target cells. Here, we investigate the biophysical function and structural interactions that stabilize P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e9cf8bd8b017c7ca6fbeb23160070df
https://doi.org/10.1016/j.bpj.2022.04.036

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání