Zobrazeno 1 - 10
of 896
pro vyhledávání: '"Biofarmaci"'
Autor:
Persson, Maja
Glioblastoma is the most aggressive type of primary tumor in the central nervous system (CNS tumors). It is hard to treat and has a poor prognosis for survival. Primary CSN tumors occur in approximately 1400 adults in Sweden every year and is the thi
Externí odkaz:
http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-128910
Autor:
Jessica Wagner, Karoline Degenhardt, Marleen Veit, Nikolaos Louros, Katerina Konstantoulea, Angelos Skodras, Katleen Wild, Ping Liu, Ulrike Obermüller, Vikas Bansal, Anupriya Dalmia, Lisa M. Häsler, Marius Lambert, Matthias De Vleeschouwer, Hannah A. Davies, Jillian Madine, Deborah Kronenberg-Versteeg, Regina Feederle, Domenico Del Turco, K. Peter R. Nilsson, Tammaryn Lashley, Thomas Deller, Marla Gearing, Lary C. Walker, Peter Heutink, Frederic Rousseau, Joost Schymkowitz, Mathias Jucker, Jonas J. Neher
Publikováno v:
Nature 612(7938), 123-131 (2022). doi:10.1038/s41586-022-05440-3
Nature 612, 123-131 (2022)
Nature 612, 123-131 (2022)
Aggregates of medin amyloid (a fragment of the protein MFG-E8, also known as lactadherin) are found in the vasculature of almost all humans over 50 years of age1,2, making it the most common amyloid currently known. We recently reported that medin al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c91db7a3628281af11389c3f665f1a
https://doi.org/10.1038/s41586-022-05440-3
https://doi.org/10.1038/s41586-022-05440-3
Autor:
Jose H Arteaga, Jorma Hinkula, Edvard C.I Smith, Britta Wahren, Abdalla J. Mohamed, Maria E. Cardona, Kristin Gustafsson, Birger Christensson
Publikováno v:
Molecular Biology Reports. 49:11187-11192
Treatment with RNAi against HIV-1 transcripts efficiently inhibits viral replication but induces selection of escape mutants; therefore, the CCR5 coreceptor was suggested as an additional target. Blocking viral and host transcripts improved the antiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fe54446ea0ada4efdf481db98f99483
https://doi.org/10.1007/s11033-022-07899-9
https://doi.org/10.1007/s11033-022-07899-9
Autor:
Heather H. C. Lau, Ivan Martinez-Valbuena, Raphaella W. L. So, Surabhi Mehra, Nicholas R. G. Silver, Alison Mao, Erica Stuart, Cian Schmitt-Ulms, Bradley T. Hyman, Martin Ingelsson, Gabor G. Kovacs, Joel C. Watts
Publikováno v:
Acta Neuropathologica Communications. 11
Unique strains of α-synuclein aggregates have been postulated to underlie the spectrum of clinical and pathological presentations seen across the synucleinopathies. Whereas multiple system atrophy (MSA) is associated with a predominance of oligodend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8190434c1d603f1f747b008cb070367
https://doi.org/10.1186/s40478-023-01570-5
https://doi.org/10.1186/s40478-023-01570-5
Autor:
Thomas Wieloch
Publikováno v:
New Phytologist. 235:1310-1314
Despite significant research efforts, the question of whether rising atmospheric CO2 concentrations (Ca) affect leaf respiration remains unanswered. Here, I reanalyse published hydrogen isotope abundances in starch glucose of sunflower leaves. I repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b717d408f75eabf8a2a340be65e27d38
https://doi.org/10.1111/nph.18226
https://doi.org/10.1111/nph.18226
Autor:
Lu Lu, Linda Åkerbladh, Shabbir Ahmad, Vivek Konda, Sha Cao, Anthony Vocat, Louis Maes, Stewart T. Cole, Diarmaid Hughes, Mats Larhed, Peter Brandt, Anders Karlén, Sherry L. Mowbray
Publikováno v:
ACS Infectious Diseases
Type II NADH dehydrogenase (NDH-2) is an essential component of electron transfer in many microbial pathogens but has remained largely unexplored as a potential drug target. Previously, quinolinyl pyrimidines were shown to inhibit Mycobacterium tuber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a39718c8f3bfe61b328322f78be178
https://doi.org/10.1021/acsinfecdis.1c00413
https://doi.org/10.1021/acsinfecdis.1c00413
Autor:
Salphale, Sumant Yogesh
Under senare år har målinriktad terapi varit ett växande område inom cancerterapi som en mer målinriktad behandling än kemoterapi. Dessa behandlingar baseras främst på antikroppsbaserade läkemedel som är ganska stora och komplexa, vilket ö
Externí odkaz:
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-341764
Autor:
Salim, Intisar
Huntingtons sjukdom (HD) är ett neurodegenerativt tillstånd som orsakas av mutationer i huntingtin gen (Htt), och resulterar till upprepade glutamin (polyQ) i Htt-proteinet. Muterad Htt kan inte vika sig ordentligt och börjar därför aggregera i
Externí odkaz:
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-341730
Autor:
Lindén, Ellinor
microRNA (miRNA) är korta icke-kodande RNA sekvenser som har fått ökande uppmärksamhet då de kan binda till mRNA och styra vårt genuttryck. Omkring trettio procent av våra proteinkodande gener styrs av miRNA. miRNA binder till mRNA vilket hind
Externí odkaz:
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-341724
Autor:
Lin, Yuyang
Ubiquitinbindande protein 2-liknande (UBAP2L) och Ras GTPas-aktiverande proteinsbindande protein 1 (G3BP1) är två kärn-RNA-bindande proteiner (RBPs) som är involverade i bildandet av SGs. Nyligen genomförda studier föreslog att UBAP2L kan funge
Externí odkaz:
http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-341766