Zobrazeno 1 - 10
of 320
pro vyhledávání: '"Biocomputational method"'
Autor:
Aditi Ajith Pujar, Arnab Barua, Partha Sarathi Dey, Divyoj Singh, Ushasi Roy, Mohit Kumar Jolly, Haralampos Hatzikirou
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110569- (2024)
Summary: Notch-Delta-Jagged (NDJ) signaling among neighboring cells contributes crucially to spatiotemporal pattern formation and developmental decision-making. Despite numerous detailed mathematical models, their high-dimensionality parametric space
Externí odkaz:
https://doaj.org/article/d2350b3ceb6e483d85e1a358944fcf42
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110807- (2024)
Summary: To understand the decision process of genomic sequence-to-function models, explainable AI algorithms determine the importance of each nucleotide in a given input sequence to the model’s predictions and enable discovery of cis-regulatory mo
Externí odkaz:
https://doaj.org/article/8f3a383a731246f99583eb388e538124
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110371- (2024)
Summary: Ab initio computational reconstructions of protein-protein interaction (PPI) networks will provide invaluable insights into cellular systems, enabling the discovery of novel molecular interactions and elucidating biological mechanisms within
Externí odkaz:
https://doaj.org/article/37b37cb66f144cc782610e2d61e925b0
Autor:
Gil Sorek, Yulia Haim, Vered Chalifa-Caspi, Or Lazarescu, Maya Ziv-Agam, Tobias Hagemann, Pamela Arielle Nono Nankam, Matthias Blüher, Idit F. Liberty, Oleg Dukhno, Ivan Kukeev, Esti Yeger-Lotem, Assaf Rudich, Liron Levin
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110368- (2024)
Summary: Deconvolution algorithms mostly rely on single-cell RNA-sequencing (scRNA-seq) data applied onto bulk RNA-sequencing (bulk RNA-seq) to estimate tissues’ cell-type composition, with performance accuracy validated on deposited databases. Adi
Externí odkaz:
https://doaj.org/article/120ff37dd2ea4aedb2a1d37c407109f6
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110147- (2024)
Summary: Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease with no cure. Human endogenous retroviruses (HERVs) have been implicated in its pathogenesis but their relevance to ALS is not fully understood. We examined
Externí odkaz:
https://doaj.org/article/ad737de41ccc44ca84dce6fe71068948
Autor:
Paul C. Lee, In-Hyuk Jung, Shreeya Thussu, Ved Patel, Ryan Wagoner, Kendall H. Burks, Junedh Amrute, Jared S. Elenbaas, Chul Joo Kang, Erica P. Young, Philipp E. Scherer, Nathan O. Stitziel
Publikováno v:
iScience, Vol 27, Iss 7, Pp 110104- (2024)
Summary: Coronary artery disease (CAD) remains a leading cause of disease burden globally, and there is a persistent need for new therapeutic targets. Instrumental variable (IV) and genetic colocalization analyses can help identify novel therapeutic
Externí odkaz:
https://doaj.org/article/f1c5ae12bdf0423691d81d9943e37603
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110032- (2024)
Summary: Evaluation of the binding affinities of drugs to proteins is a crucial process for identifying drug pharmacological actions, but it requires three dimensional structures of proteins. Herein, we propose novel computational methods to predict
Externí odkaz:
https://doaj.org/article/080ae99a16964a4c98b048c256e60fb7
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109926- (2024)
Summary: Cytotoxic T lymphocyte (CTL) and terminal exhausted T lymphocyte (ETL) activities crucially influence immune checkpoint inhibitor (ICI) response. Despite this, the efficacy of ETL and CTL transcriptomic signatures for response prediction rem
Externí odkaz:
https://doaj.org/article/647d631436784c3cb665439df96dda14
Autor:
Jize Xie, Xubin Zheng, Jianlong Yan, Qizhi Li, Nana Jin, Shuojia Wang, Pengfei Zhao, Shuai Li, Wanfu Ding, Lixin Cheng, Qingshan Geng
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109908- (2024)
Summary: Accurate detection of pathogens, particularly distinguishing between Gram-positive and Gram-negative bacteria, could improve disease treatment. Host gene expression can capture the immune system’s response to infections caused by various p
Externí odkaz:
https://doaj.org/article/6ff7ccf657524ea2b9a69a9c0693b95d
Autor:
Li Wang, Sudeh Izadmehr, John P. Sfakianos, Michelle Tran, Kristin G. Beaumont, Rachel Brody, Carlos Cordon-Cardo, Amir Horowitz, Robert Sebra, William K. Oh, Nina Bhardwaj, Matthew D. Galsky, Jun Zhu
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109928- (2024)
Summary: Interactions within the tumor microenvironment (TME) significantly influence tumor progression and treatment responses. While single-cell RNA sequencing (scRNA-seq) and spatial genomics facilitate TME exploration, many clinical cohorts are a
Externí odkaz:
https://doaj.org/article/78cfe216b02f40508c2ce44eed5d4500