Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Biochemistry/RNA Structure"'
Autor:
Birgit Seidelt, Shashi Bhushan, Jens Frauenfeld, Thomas Hoffmann, Thorsten Mielke, Otto Berninghausen, Roland Beckmann, Daniel N. Wilson
Publikováno v:
PLoS Biology, Vol 9, Iss 1, p e1000581 (2011)
PLoS Biology
PLoS Biology
A structure of a ribosome stalled during translation of the SecM peptide provides insight into the mechanism by which the large subunit active site is inactivated.
As nascent polypeptide chains are synthesized, they pass through a tunnel in the
As nascent polypeptide chains are synthesized, they pass through a tunnel in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24be6da517483871896722bc99e337da
http://europepmc.org/articles/PMC3022528?pdf=render
http://europepmc.org/articles/PMC3022528?pdf=render
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
PLoS ONE
PLoS ONE
Alzheimer's disease (AD) is the main cause of dementia in our increasingly aging population. The debilitating cognitive and behavioral symptoms characteristic of AD make it an extremely distressing illness for patients and carers. Although drugs have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6003ebab15a9de512a9502a0e4769cbd
http://europepmc.org/articles/PMC2946912?pdf=render
http://europepmc.org/articles/PMC2946912?pdf=render
Autor:
Julien Lescar, Christian G. Noble, Li Jian Yap, Christophe Bodenreider, Siew Pheng Lim, Ka Yan Chung, Pei Yong Shi, Dahai Luo
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 9 (2010)
PLoS ONE, Vol 5, Iss 9 (2010)
The N-terminal domain of the flavivirus NS5 protein functions as a methyltransferase (MTase). It sequentially methylates the N7 and 2'-O positions of the viral RNA cap structure (GpppA→(7me)GpppA→(7me)GpppA(2'-O-me)). The same NS5 domain could al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8fc4e466ab870736880ae673c525a6
http://europepmc.org/articles/PMC2941465
http://europepmc.org/articles/PMC2941465
Autor:
John Martin, Aled O. Phillips, James E. Redman, Robert H. Jenkins, Rasha Bennagi, Donald James Fraser
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12283 (2010)
PLoS ONE
PLoS ONE
Transforming growth factor-β(1) (TGF-β(1)) regulates cellular proliferation, differentiation, migration, and survival. The human TGF-β(1) transcript is inherently poorly translated, and translational activation has been documented in relation to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e29d960564044330fef2524c948ec66
https://orca.cardiff.ac.uk/id/eprint/9639/1/Conserved_Stem_Loop_Motif_5.pdf
https://orca.cardiff.ac.uk/id/eprint/9639/1/Conserved_Stem_Loop_Motif_5.pdf
Publikováno v:
PLoS Pathogens, Vol 6, Iss 7, p e1000999 (2010)
PLoS Pathogens
PLoS Pathogens
The cap structure of eukaryotic messenger RNAs is initially elaborated through three enzymatic reactions: hydrolysis of the 5′-triphosphate, transfer of guanosine through a 5′-5′ triphosphate linkage and N7-methylation of the guanine cap. Three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e31d367f737ad551468381322880b379
http://europepmc.org/articles/PMC2904801?pdf=render
http://europepmc.org/articles/PMC2904801?pdf=render
Autor:
Martin Hammarström, P. Schutz, Wolfram Tempel, R. Collins, Hee-Won Park, L. Holmberg-Schiavone, Martin Högbom, Tobias Karlberg, Susanne van den Berg, Herwig Schüler, Martin Moche, Lari Lehtiö, Ann-Gerd Thorsell
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 9 (2010)
PLoS ONE, Vol 5, Iss 9 (2010)
DEAD-box RNA helicases play various, often critical, roles in all processes where RNAs are involved. Members of this family of proteins are linked to human disease, including cancer and viral infections. DEAD-box proteins contain two conserved domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2db3199991ef82b3af3cbc9cf9bb303
https://pubmed.ncbi.nlm.nih.gov/20941364
https://pubmed.ncbi.nlm.nih.gov/20941364
Publikováno v:
PLoS Biology
PLoS Biology, Vol 8, Iss 6, p e1000392 (2010)
PLoS Biology, Vol 8, Iss 6, p e1000391 (2010)
PLoS Biology, Vol 8, Iss 6, p e1000392 (2010)
PLoS Biology, Vol 8, Iss 6, p e1000391 (2010)
Studies of mobile group II introns from a thermophilic cyanobacterium reveal how these introns proliferate within genomes and might explain the origin of introns and retroelements in higher organisms.
Mobile group II introns, which are found in
Mobile group II introns, which are found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0202f208b2529d677ca934617008f5c7
https://pubmed.ncbi.nlm.nih.gov/20543989
https://pubmed.ncbi.nlm.nih.gov/20543989
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 8, p e12235 (2010)
PLoS ONE, Vol 5, Iss 8, p e12235 (2010)
Mitochondrial mRNA editing in Trypanosoma brucei requires the specific interaction of a guide RNA with its cognate mRNA. Hundreds of gRNAs are involved in the editing process, each needing to target their specific editing domain within the target mes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62bcf38d99ab5889c062e61d7b4ac3c0
https://pubmed.ncbi.nlm.nih.gov/20808932
https://pubmed.ncbi.nlm.nih.gov/20808932
Autor:
Kevin M. Weeks, Caia D. S. Duncan
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e8983 (2010)
PLoS ONE
PLoS ONE
Most large ribozymes require protein cofactors in order to function efficiently. The yeast mitochondrial bI3 group I intron requires two proteins for efficient splicing, Mrs1 and the bI3 maturase. Mrs1 has evolved from DNA junction resolvases to func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cba50e772e80efb7893163b4c015869
http://europepmc.org/articles/PMC2813881?pdf=render
http://europepmc.org/articles/PMC2813881?pdf=render
Autor:
Philippe Clerc, Agnès Dubois, Magali Blaud, Laetitia Fouillen, Philip Avner, Sylvain Maenner, Christiane Branlant, Athanase Visvikis, Virginie Marchand, Alain Van Dorsselaer, Sarah Sanglier-Cianférani, Anne Savoye
Publikováno v:
PLoS Biology
PLoS Biology, Public Library of Science, 2010, 8 (1), pp.e1000276. ⟨10.1371/journal.pbio.1000276⟩
PLoS Biology, Public Library of Science, 2010, 8 (1), pp.1000276-1-1000276-16. ⟨10.1371/journal.pbio.1000276⟩
PLoS Biology, Vol 8, Iss 1, p e1000276 (2010)
PLoS Biology, 2010, 8 (1), pp.e1000276. ⟨10.1371/journal.pbio.1000276⟩
PLoS Biology, Public Library of Science, 2010, 8 (1), pp.e1000276. ⟨10.1371/journal.pbio.1000276⟩
PLoS Biology, Public Library of Science, 2010, 8 (1), pp.1000276-1-1000276-16. ⟨10.1371/journal.pbio.1000276⟩
PLoS Biology, Vol 8, Iss 1, p e1000276 (2010)
PLoS Biology, 2010, 8 (1), pp.e1000276. ⟨10.1371/journal.pbio.1000276⟩
Structural analyses provide new insights into the folding of the A region of the Xist RNA, which plays a crucial role in X chromosome inactivation, and its mechanism of protein recruitment.
In placental mammals, inactivation of one of the X chro
In placental mammals, inactivation of one of the X chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb0e59dff809bb992855409961ef0b0
https://hal.univ-lorraine.fr/hal-02270594
https://hal.univ-lorraine.fr/hal-02270594