Výsledky vyhledávání - "Biochemistry/Macromolecular Chemistry"

Structural Basis of Response Regulator Dephosphorylation by Rap Phosphatases

Autor: Vijay Parashar, Matthew B. Neiditch, Nicolas Mirouze, David A. Dubnau

Publikováno v: PLoS Biology
PLoS Biology, Vol 9, Iss 2, p e1000589 (2011)

Crystallographic, biochemical, and genetic studies reveal the mechanism of Rap protein phosphatase activity within the phosphorelay pathway leading to sporulation in Bacillus species.
Bacterial Rap family proteins have been most extensively stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd3c3e646c7cfd25bcbd6bf1d00bdcc7
http://europepmc.org/articles/PMC3035606

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Investigation of parameters that affect the success rate of microarray-based allele-specific hybridization assays

Autor: Lena Poulsen, Lisbeth Birk Møller, Martin Dufva, Martin Jensen Søe

Publikováno v: PLoS ONE, Vol 6, Iss 3, p e14777 (2011)
Poulsen, L, Søe, M J, Moller, L B & Dufva, M 2011, ' Investigation of Parameters that Affect the Success Rate of Microarray-Based Allele-Specific Hybridization Assays ', P L o S One, vol. 6, no. 3, pp. e14777 . https://doi.org/10.1371/journal.pone.0014777
PLoS ONE
ResearcherID

Background The development of microarray-based genetic tests for diseases that are caused by known mutations is becoming increasingly important. The key obstacle to developing functional genotyping assays is that such mutations need to be genotyped r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c4b1b6b48b5131d1611fcd81312436
http://europepmc.org/articles/PMC3062541?pdf=render

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Evolution of a signaling nexus constrained by protein interfaces and conformational States

Autor: Alan M. Jones, Brenda Temple, Corbin D. Jones

Publikováno v: PLoS Computational Biology, Vol 6, Iss 10, p e1000962 (2010)
PLoS Computational Biology

Heterotrimeric G proteins act as the physical nexus between numerous receptors that respond to extracellular signals and proteins that drive the cytoplasmic response. The Gα subunit of the G protein, in particular, is highly constrained due to its m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7941d3013b97c6a2ba71eef7e6ced18
http://europepmc.org/articles/PMC2954821?pdf=render

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Integrating ion mobility mass spectrometry with molecular modelling to determine the architecture of multiprotein complexes

Autor: Ah Young Park, Suk Joon Hyung, Daniel Barsky, Carol V. Robinson, Brandon T. Ruotolo, Argyris Politis

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12080 (2010)
PLoS ONE

Current challenges in the field of structural genomics point to the need for new tools and technologies for obtaining structures of macromolecular protein complexes. Here, we present an integrative computational method that uses molecular modelling,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03fb374e9abe43c12567f376b9b4dea
http://europepmc.org/articles/PMC2919415?pdf=render

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Purification and Functional Characterisation of Rhiminopeptidase A, a Novel Aminopeptidase from the Venom of Bitis gabonica rhinoceros

Autor: Kimberly A. Watson, Robert A. Harrison, E. Gail Hutchinson, Sakthivel Vaiyapuri, Simon C. Wagstaff, Jonathan M. Gibbins

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 4, Iss 8, p e796 (2010)

Background Snake bite is a major neglected public health issue within poor communities living in the rural areas of several countries throughout the world. An estimated 2.5 million people are bitten by snakes each year and the cost and lack of effica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b3f8ac8ead1ff1b2ea964010a1ae5f
http://europepmc.org/articles/PMC2919393

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Characterizing DNA condensation and conformational changes in organic solvents

Autor: Yen K. Luu, Dehai Liang, Fuyou Ke, Michael Hadjiargyrou

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 10, p e13308 (2010)

Organic solvents offer a new approach to formulate DNA into novel structures suitable for gene delivery. In this study, we examined the in situ behavior of DNA in N, N-dimethylformamide (DMF) at low concentration via laser light scattering (LLS), TEM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a70014380f4d7e0c967911b2ecd0615a
https://pubmed.ncbi.nlm.nih.gov/20949017

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Characterization of a novel esterase Rv0045c from Mycobacterium tuberculosis

Autor: Xiangdong Zheng, Hai Pang, Jiubiao Guo, Tingyi Wen, Lipeng Xu, Kehui Xu, Siguo Liu, Shentao Li, Zhongyuan Liu

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 10 (2010)

BackgroundIt was proposed that there are at least 250 enzymes in M. tuberculosis involved in lipid metabolism. Rv0045c was predicted to be a hydrolase by amino acid sequence similarity, although its precise biochemical characterization and function r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69157c30c29dfff9d97f5fb08e4b5e0c
https://pubmed.ncbi.nlm.nih.gov/20957207

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Deciphering the catalytic machinery in 30S ribosome assembly GTPase YqeH

Autor: B Anand, Parag Surana, Balaji Prakash

Publikováno v: PLoS ONE, Vol 5, Iss 4, p e9944 (2010)
PLoS ONE

Background YqeH, a circularly permuted GTPase (cpGTPase), which is conserved across bacteria and eukaryotes including humans is important for the maturation of small (30S) ribosomal subunit in Bacillus subtilis. Recently, we have shown that it binds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2454693d6e7434a3fa34a315a1f672e9
http://europepmc.org/articles/PMC2848588?pdf=render

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Nitrated α-Synuclein Induces the Loss of Dopaminergic Neurons in the Substantia Nigra of Rats

Autor: Zhongwang Yu, Xiao-Hui Xu, Cheng He, Chun Hu, Zhaohuan Zhang, Zhenghua Xiang, Jianfeng Zhou

Publikováno v: PLoS ONE
PLoS ONE, Vol 5, Iss 4, p e9956 (2010)

BACKGROUND: The pathology of Parkinson's disease (PD) is characterized by the degeneration of the nigrostriatal dopaminergic pathway, as well as the formation of intraneuronal inclusions known as Lewy bodies and Lewy neurites in the substantia nigra.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1d23aeae552a20e625ee133ee0110a
http://europepmc.org/articles/PMC2851648

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Quantitative comparison of catalytic mechanisms and overall reactions in convergently evolved enzymes: implications for classification of enzyme function

Autor: John B. O. Mitchell, Daniel Almonacid, Patricia C. Babbitt, Emmanuel R. Yera

Publikováno v: PLoS Computational Biology, Vol 6, Iss 3, p e1000700 (2010)
PLoS computational biology, vol 6, iss 3
PLoS Computational Biology

Functionally analogous enzymes are those that catalyze similar reactions on similar substrates but do not share common ancestry, providing a window on the different structural strategies nature has used to evolve required catalysts. Identification an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabdc56caca29ed63546e8fec5077f9e
http://europepmc.org/articles/PMC2837397?pdf=render

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