Zobrazeno 1 - 10 of 88 pro vyhledávání: '"Biochemistry/Experimental Biophysical Methods"'
1
Heterologous amyloid seeding: revisiting the role of acetylcholinesterase in Alzheimer's disease
Autor: Michael Shaw, Benjamin Thomas, David J. Vaux, Létitia Jean, Abdessamad Tahiri-Alaoui
Publikováno v: PLoS ONE, Vol 2, Iss 7, p e652 (2007)
PLoS ONE
Neurodegenerative diseases associated with abnormal protein folding and ordered aggregation require an initial trigger which may be infectious, inherited, post-inflammatory or idiopathic. Proteolytic cleavage to generate vulnerable precursors, such a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b80e17594101239d96b635b77d695e
https://doi.org/10.1371/journal.pone.0000652
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2
Force-Velocity Measurements of a Few Growing Actin Filaments
Autor: Alexis Mazurier, Marie-France Carlier, Emmanuèle Helfer, Coraline Brangbour, Olivia du Roure, Jean Baudry, Jérôme Bibette, Damien Demoulin, Marc Fermigier
Publikováno v: PLoS Biology
PLoS Biology, Public Library of Science, 2011, 9, pp.e1000613. ⟨10.1371/journal.pbio.1000613⟩
PLoS Biology, 2011, 9, pp.e1000613. ⟨10.1371/journal.pbio.1000613⟩
PLoS Biology, Vol 9, Iss 4, p e1000613 (2011)
The authors propose a new mechanism for actin-based force generation based on results using chains of actin-grafted magnetic colloids.
The polymerization of actin in filaments generates forces that play a pivotal role in many cellular processes.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5ea9de9a9e656fdf1f15bb5856feda2
https://hal.archives-ouvertes.fr/hal-00647601
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3
Membrane Permeabilization by Oligomeric α-Synuclein: In Search of the Mechanism
Autor: Mireille Maria Anna Elisabeth Claessens, Vinod Subramaniam, Bart D. van Rooijen
Publikováno v: PLoS ONE, 5(12). Public Library of Science
van Rooijen, B D, Claessens, M M A E & Subramaniam, V 2010, ' Membrane Permeabilization by Oligomeric α-Synuclein : In Search of the Mechanism ', PLoS ONE, vol. 5, no. 12, pp. e14292 . https://doi.org/10.1371/journal.pone.0014292
PLoS ONE, Vol 5, Iss 12, p e14292 (2010)
PLoS ONE
BACKGROUND: The question of how the aggregation of the neuronal protein α-synuclein contributes to neuronal toxicity in Parkinson's disease has been the subject of intensive research over the past decade. Recently, attention has shifted from the amy
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f346c4ba1c7ca8b6134d652634489a
https://research.vu.nl/en/publications/1653345f-fd80-4e66-a836-99e220cb5285
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4
The G215R mutation in the Cl-/H+-antiporter ClC-7 found in ADO II osteopetrosis does not abolish function but causes a severe trafficking defect
Autor: Schulze, K., Werner, J., Stauber, T., Henriksen, K., Fendler, K.
Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12585 (2010)
PLoS ONE
BackgroundClC-7 is a ubiquitous transporter which is broadly expressed in mammalian tissues. It is implied in the pathogenesis of lysosomal storage disease and osteopetrosis. Because of its endosomal/lysosomal localization it is still poorly characte
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5fb313a2a98a8c8b4be1dde69e8fbd8d
http://publikationen.ub.uni-frankfurt.de/files/22629/journal.pone.0012585.pdf
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5
Quantitative phosphoproteomics of proteasome inhibition in multiple myeloma cells
Autor: Chuan-Le Xiao, Li-Jun Bi, Feng Ge, Xin-Feng Yin, Sheng-Ce Tao, Sheng Xiong, Liping Li, Hai-Tao Jia, Chun-Hua Lu, Qing-Yu He
Publikováno v: PLoS ONE, Vol 5, Iss 9 (2010)
PLoS ONE
BackgroundThe proteasome inhibitor bortezomib represents an important advance in the treatment of multiple myeloma (MM). Bortezomib inhibits the activity of the 26S proteasome and induces cell death in a variety of tumor cells; however, the mechanism
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8462d815a59759bba1e34715d083c47
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20927383/?tool=EBI
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6
Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation
Autor: Dominik Wiemuth, Fiona J. McDonald, Peter M. Snyder, Kevin Ly, Paul H. Teesdale-Spittle, J. Shaun Lott, Ying Ke
Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12163 (2010)
PLoS ONE
Background The epithelial sodium channel (ENaC) is an integral component of the pathway for Na+ absorption in epithelial cells. The ubiquitin ligases Nedd4 and Nedd4-2 bind to ENaC and decrease its activity. Conversely, Serum- and Glucocorticoid regu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4e57d03f9ed9d1b5617179ea6be87e
http://europepmc.org/articles/PMC2921341?pdf=render
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7
Insights into the mechanism of ligand binding to octopine dehydrogenase from Pecten maximus by NMR and crystallography
Autor: Sander H. J. Smits, Tatu Meyer, Nadine van Os, Lutz Schmitt, Andre Mueller, Manfred K. Grieshaber, Dieter Willbold, Matthias Stoldt
Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12312 (2010)
PLoS ONE
PLoS one 5, e12312 (2010). doi:10.1371/journal.pone.0012312
Octopine dehydrogenase (OcDH) from the adductor muscle of the great scallop, Pecten maximus, catalyzes the NADH dependent, reductive condensation of L-arginine and pyruvate to octopine, NAD(+), and water during escape swimming and/or subsequent recov
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463256cc0a194d4d0ccc509b986e0e4a
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20808820/?tool=EBI
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8
Imaging beta-galactosidase activity in human tumor xenografts and transgenic mice using a chemiluminescent substrate
Autor: Ralph P. Mason, Li Liu
Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12024 (2010)
PLoS ONE
Background Detection of enzyme activity or transgene expression offers potential insight into developmental biology, disease progression, and potentially personalized medicine. Historically, the lacZ gene encoding the enzyme β-galactosidase has been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::913a782e3200d33a5539f16dc07f6be2
http://europepmc.org/articles/PMC2917367?pdf=render
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9
Integrating ion mobility mass spectrometry with molecular modelling to determine the architecture of multiprotein complexes
Autor: Ah Young Park, Suk Joon Hyung, Daniel Barsky, Carol V. Robinson, Brandon T. Ruotolo, Argyris Politis
Publikováno v: PLoS ONE, Vol 5, Iss 8, p e12080 (2010)
PLoS ONE
Current challenges in the field of structural genomics point to the need for new tools and technologies for obtaining structures of macromolecular protein complexes. Here, we present an integrative computational method that uses molecular modelling,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03fb374e9abe43c12567f376b9b4dea
http://europepmc.org/articles/PMC2919415?pdf=render
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10
Characterisation of Peptide Microarrays for Studying Antibody-Antigen Binding Using Surface Plasmon Resonance Imagery
Autor: Claude Nogues, Ashley M. Buckle, Ruby H. P. Law, Malcolm Buckle, Christopher G. Langendorf, Hervé Leh
Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2010, ⟨10.1371/journal.pone.0012152⟩
PLoS ONE, Vol 5, Iss 8, p e12152 (2010)
Background Non-specific binding to biosensor surfaces is a major obstacle to quantitative analysis of selective retention of analytes at immobilized target molecules. Although a range of chemical antifouling monolayers has been developed to address t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb403ae041b81968f12bc9f1bc7e767
http://europepmc.org/articles/PMC2921342
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