Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Biochemical switches in the cell cycle"'
Autor:
John J. Tyson, Wolfgang Zachariae
Publikováno v:
Current Biology
Alternation between DNA replication in the mother cell (S phase) and equal partitioning of the replicated chromosomes to the daughter cells (M phase) during eukaryotic cell division is governed by switches that flip protein kinases on and off. New wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b421e42b6f165af0958e6addb2b853b
https://doi.org/10.1016/j.cub.2016.11.007
https://doi.org/10.1016/j.cub.2016.11.007
Autor:
Gary J. Gorbsky, Sushama Sivakumar
Publikováno v:
Nature Reviews Molecular Cell Biology. 16:82-94
The appropriate timing of events that lead to chromosome segregation during mitosis and cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute to tumorigenesis. Key mitotic regulators are controlled through ubiq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c9b65fdee0e0da4dd42950fd7d7ed6
https://doi.org/10.1038/nrm3934
https://doi.org/10.1038/nrm3934
Publikováno v:
Cell cycle (Georgetown, Tex.). 16(20)
The transitions between phases of the cell cycle have evolved to be robust and switch-like, which ensures temporal separation of DNA replication, sister chromatid separation, and cell division. Mathematical models describing the biochemical interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e521850ba8a89eb8afa07caf67bb8b
https://pubmed.ncbi.nlm.nih.gov/28902568
https://pubmed.ncbi.nlm.nih.gov/28902568
Publikováno v:
The Journal of Cell Biology
PP2ACdc55 dephosphorylates APC/CCdc20 to prevent anaphase, an effect that is counteracted by Cdc28/Clbs to allow for spindle checkpoint adaptation.
The spindle checkpoint arrests cells in metaphase until all chromosomes are properly attached to
The spindle checkpoint arrests cells in metaphase until all chromosomes are properly attached to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee97962fc611e75d0381f1e95297b403
https://doi.org/10.1083/jcb.201303033
https://doi.org/10.1083/jcb.201303033
Publikováno v:
The Journal of Cell Biology
The spindle checkpoint, APC/C-Cdc20, and APC/C-Cdh1 act successively to connect disappearance of geminin and cyclin B1 to a peak of Cdt1 and Cdc6.
DNA replication depends on a preceding licensing event by Cdt1 and Cdc6. In animal cells, relicens
DNA replication depends on a preceding licensing event by Cdt1 and Cdc6. In animal cells, relicens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9aebdaea5f201df900a9f7fe5ce9dc2
https://doi.org/10.1083/jcb.201211019
https://doi.org/10.1083/jcb.201211019
Autor:
Bethany Harker, Gregory Moorhead, Orsolya Kapuy, Nikolaos Parisis, Daniel Fisher, Liliana Krasinska, Michel Rossignol, Bela Novak, Maria Rosa Domingo-Sananes
Bistability of the Cdk1-Wee1-Cdc25 mitotic control network underlies the switch-like transitions between interphase and mitosis. Here, we show by mathematical modeling and experiments in Xenopus egg extracts that protein phosphatase 2A (PP2A), which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91274d1f4a36837f856fcfcfd4279a50
https://ora.ox.ac.uk/objects/uuid:c33a8ead-e80f-4124-8018-df4b23020ae2
https://ora.ox.ac.uk/objects/uuid:c33a8ead-e80f-4124-8018-df4b23020ae2
Autor:
Mariya Georgieva, Shaereh Mashayekhan, Marion Peter, Abdelhalim Loukil, Jean-Marie Blanchard, Fanny Izard, Andrea Parmeggiani
Publikováno v:
Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 6, pp.27215. ⟨10.1038/srep27215⟩
Scientific Reports, Nature Publishing Group, 2016, 6, pp.27215. ⟨10.1038/srep27215⟩
Cyclin A2 is a key player in the regulation of the cell cycle. Its degradation in mid-mitosis depends primarily on the ubiquitin-proteasome system (UPS), while autophagy also contributes. However, a fraction of cyclin A2 persists beyond metaphase. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8154726f1b5503ab7cdaa6b8e6f5a542
https://hal.archives-ouvertes.fr/hal-01345990/document
https://hal.archives-ouvertes.fr/hal-01345990/document
Autor:
Fengchao Liang, Suhui Zhang, Xiaoxuan Chen, Xuan Zou, Bogang Teng, Xiangyu Kong, Suhang Hua, Wei Yang, Dan Ma, Yue Dai, Wenxin Zhuang, Su Wang, Yongxing Zhang, Xiuyi Yu
Publikováno v:
Scientific Reports
Here we show that A-kinase anchoring protein 95 (AKAP95) and connexin 43 (Cx43) dynamically interact during cell cycle progression of lung cancer A549 cells. Interaction between AKAP95 and Cx43 at different cell cycle phases was examined by tandem ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d1f9d41ddc59c292f4f9cf1fe54a927
Publikováno v:
Methods in Molecular Biology ISBN: 9781493929566
Tightly controlled degradation of specific regulatory proteins is crucial for transitioning to the next cell cycle phase, ensuring precise DNA replication and an equal distribution of chromosomes to provide genomic stability and avoid tumorigenesis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b44bb4e6092b58f4a9a0292069c9f5f2
https://doi.org/10.1007/978-1-4939-2957-3_11
https://doi.org/10.1007/978-1-4939-2957-3_11