A Modular In Vitro Platform for the Production of Terpenes and Polyketides from CO 2

Autor: Christoph Diehl, Srividhya Sundaram, Jan Bamberger, Tobias J. Erb, Niña Socorro Cortina, Nicole Paczia

Publikováno v: Angew Chem Int Ed Engl
Angewandte Chemie (International Ed. in English)

A long‐term goal in realizing a sustainable biocatalysis and organic synthesis is the direct use of the greenhouse gas CO2 as feedstock for the production of bulk and fine chemicals, such as pharmaceuticals, fragrances and food additives. Here we d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088a8aae2106a1dba777c8d35325571f
https://doi.org/10.1002/anie.202102333

Discovery and Design of Family VIII Carboxylesterases as Highly Efficient Acyltransferases

Autor: Müller, Henrik, Godehard, Simon P., Palm, Gottfried J., Berndt, Leona, Badenhorst, Christoffel P. S., Becker, Ann‐Kristin, Lammers, Michael, Bornscheuer, Uwe T.

Publikováno v: Angewandte Chemie (International Ed. in English)

Promiscuous acyltransferase activity is the ability of certain hydrolases to preferentially catalyze acyl transfer over hydrolysis, even in bulk water. However, poor enantioselectivity, low transfer efficiency, significant product hydrolysis, and lim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14db59dc7b312a887d7316e4b8873cc6
https://doi.org/10.1002/anie.202014169

Responsive Emulsions for Sequential Multienzyme Cascades

Autor: Qingcai Zhao, Changzhu Wu, Rainer Haag, Zhiyong Sun

Publikováno v: Sun, Z, Zhao, Q, Haag, R & Wu, C 2021, ' Responsive Emulsions for Sequential Multienzyme Cascades ', Angewandte Chemie-International Edition, vol. 60, no. 15, pp. 8410-8414 . https://doi.org/10.1002/anie.202013737
Angewandte Chemie (International Ed. in English)

Multienzyme cascade biocatalysis is an efficient synthetic process, avoiding the isolation/purification of intermediates and shifting the reaction equilibrium to the product side.. However, multienzyme systems are often limited by their incompatibili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d4f29e2b3aec4ece988a68aecf92545
https://findresearcher.sdu.dk:8443/ws/files/181450121/anie.202013737.pdf

Less Unfavorable Salt Bridges on the Enzyme Surface Result in More Organic Cosolvent Resistance

Autor: Ulrich Schwaneberg, Lobna Eltoukhy, Karl-Erich Jaeger, Haiyang Cui, Lingling Zhang, Ulrich Markel, Mehdi D. Davari

Publikováno v: Angewandte Chemie 133(20), 11549-11557 (2021). doi:10.1002/ange.202101642
Angewandte Chemie / International edition 60(20), 11448-11456 (2021). doi:10.1002/anie.202101642
Angewandte Chemie (International Ed. in English)

Biocatalysis for the synthesis of fine chemicals is highly attractive but usually requires organic (co‐)solvents (OSs). However, native enzymes often have low activity and resistance in OSs and at elevated temperatures. Herein, we report a smart sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245c202938353841cddeddf30b0eb56f

Biocatalytic Friedel-Crafts Acylation and Fries Reaction

Autor: Nina G. Schmidt, Nina Richter, Karl Gruber, Birgit Wiltschi, Wolfgang Kroutil, Tea Pavkov-Keller

Publikováno v: Angewandte Chemie (International Ed. in English)

The Friedel–Crafts acylation is commonly used for the synthesis of aryl ketones, and a biocatalytic version, which may benefit from the chemo‐ and regioselectivity of enzymes, has not yet been introduced. Described here is a bacterial acyltransfe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54894b6a29b58d19565d99b001075d26
https://doi.org/10.1002/ange.201703270