Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Biobreeding rat"'
Autor:
Brian L. Furman
Publikováno v:
Current Protocols in Pharmacology
Streptozotocin (STZ) is an antibiotic that causes pancreatic islet β-cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this article are protocols for producing STZ-induced insulin d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b109ab37653d24001c13fcd73830ac
https://pubmed.ncbi.nlm.nih.gov/33905609
https://pubmed.ncbi.nlm.nih.gov/33905609
Publikováno v:
Cellular Physiology and Biochemistry, Vol 39, Iss 2, Pp 760-767 (2016)
Background/Aims: Type 1 diabetes (T1D) is characterized by absolute insulin deficiency due to destruction of pancreatic β-cells by cytokines (e.g., interleukin-1β; IL-1β) released by invading immune cells. The mechanisms by which these cytokines i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41862181092c4fe5261e70c0df2cf5b
https://doi.org/10.1159/000445666
https://doi.org/10.1159/000445666
Autor:
Tim Vanuytsel, Lucas Wauters, Mathieu Meleine, Joran Toth, Guillaume Gourcerol, Ricard Farré, Alison Accarie, Jan Tack
Publikováno v:
Neurogastroenterology and Motility
Neurogastroenterology and Motility, Wiley, 2019, pp.e13614. ⟨10.1111/nmo.13614⟩
Neurogastroenterology & Motility
Neurogastroenterology & Motility, Wiley, 2019, pp.e13614. ⟨10.1111/nmo.13614⟩
Neurogastroenterology and Motility, Wiley, 2019, pp.e13614. ⟨10.1111/nmo.13614⟩
Neurogastroenterology & Motility
Neurogastroenterology & Motility, Wiley, 2019, pp.e13614. ⟨10.1111/nmo.13614⟩
BACKGROUND: A complex interplay between a failing intestinal barrier and low-grade inflammation leading to sensorimotor disturbances is an often-cited mechanism in the pathogenesis of functional gastrointestinal disorders (FGID). However, the cause-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4710bc5967bd5618f764ae8f36d17ef2
https://doi.org/10.1111/nmo.13614
https://doi.org/10.1111/nmo.13614
Autor:
Norihide Yokoi
Publikováno v:
Diabetology International. 6:255-260
Although genetic factors are involved in the development of both type 1 (T1D) and type 2 (T2D) diabetes, a complete picture of those factors remains to be elucidated. T1D is an autoimmune disease in which the major histocompatibility complex (MHC) se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a40aaf8a2804fc3cd591fdde3a0bde40
https://doi.org/10.1007/s13340-015-0228-9
https://doi.org/10.1007/s13340-015-0228-9
Autor:
Janice Sarmiento, Åke Lernmark, Leili Marandi, Philippe Poussier, Robert H. Wallis, Gary Chao, André Veillette, Terri Ning, Andrew D. Paterson
Publikováno v:
The Journal of Immunology. 194:615-629
The R620W variant of PTPN22 is one of the major genetic risk factors for several autoimmune disorders including type 1 diabetes (T1D) in humans. In the BioBreeding T1D-prone (BBDP) rat, a single nucleotide polymorphism in Ptpn22 results in an A629T s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f85fdb6d4e3650b47e3890f7d5a1b55
https://doi.org/10.4049/jimmunol.1302689
https://doi.org/10.4049/jimmunol.1302689
Autor:
Åke Lernmark, Martin J. Hessner, Shuang Jia, Lina Åkesson, Daria La Torre, Thomas Moritz, Simon E. Regnell, Hans Stenlund
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0171372 (2017)
PLoS ONE, Vol 12, Iss 2, p e0171372 (2017)
Type 1 diabetes is associated with abberations of fat metabolism before and after the clinical onset of disease. It has been hypothesized that the absence of the effect of insulin in the liver contributes to reduced hepatic fat synthesis. We measured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e4164ae65877e2577e4514b0650a20
http://europepmc.org/articles/PMC5305198
http://europepmc.org/articles/PMC5305198
Publikováno v:
Diabetologia. 57:2366-2373
The CD40–CD154 interaction directs autoimmune inflammation. Therefore, a long-standing goal in the treatment of autoimmune disease has been to control the formation of that interaction and thereby prevent destructive inflammation. Antibodies blocki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab23c5ca5816b0c62336d76ee6e90a45
https://doi.org/10.1007/s00125-014-3342-5
https://doi.org/10.1007/s00125-014-3342-5
Autor:
Gen-Sheng Wang, Dirk Wedekind, Conny Gysemans, Lorella Marselli, Hans-Jürgen Hedrich, Sigurd Lenzen, Yutaka Nakaya, Piero Marchetti, Fraser W. Scott, T Arndt, Jürgen Klempnauer, Chantal Mathieu, Andreas Meyer zu Vilsendorf, Anne Jörns, Nagakatsu Harada
Publikováno v:
Diabetologia; Vol 57
Research on the pathogenesis of type 1 diabetes relies heavily on good animal models. The aim of this work was to study the translational value of animal models of type 1 diabetes to the human situation.We compared the four major animal models of spo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5d9f05654439b67da06497382547ce
https://doi.org/10.1007/s00125-013-3125-4
https://doi.org/10.1007/s00125-013-3125-4
Autor:
Leili Marandi, Marie-Thérèse Bihoreau, Philippe Poussier, Dominique Gauguier, Sheela Ramanathan, Andrew D. Paterson
Publikováno v:
Scopus-Elsevier
Spontaneous type 1 diabetes in BB rats is dependent on the RT1u MHC haplotype and homozygosity for an allele at the Lyp locus, which is responsible for a peripheral T-lymphopenia. Genetic studies have shown that there are other, as yet unidentified,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e478eea29cf1548bfe212adf1d6dd8
https://ora.ox.ac.uk/objects/uuid:5a2be81c-dcc2-4e7d-8c50-ce115419652b
https://ora.ox.ac.uk/objects/uuid:5a2be81c-dcc2-4e7d-8c50-ce115419652b
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