Zobrazeno 1 - 10
of 471
pro vyhledávání: '"Biobank Team"'
Autor:
Robert F. Hillary, Danni A. Gadd, Zhana Kuncheva, Tasos Mangelis, Tinchi Lin, Kyle Ferber, Helen McLaughlin, Heiko Runz, Biogen Biobank Team, Riccardo E. Marioni, Christopher N. Foley, Benjamin B. Sun
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Understanding how gene-environment interactions (GEIs) influence the circulating proteome could aid in biomarker discovery and validation. The presence of GEIs can be inferred from single nucleotide polymorphisms that associate with phenotyp
Externí odkaz:
https://doaj.org/article/b3af4159742445ef8cc58e96088e9052
Autor:
Ruoyu Tian, Tian Ge, Hyeokmoon Kweon, Daniel B. Rocha, Max Lam, Jimmy Z. Liu, Kritika Singh, Biogen Biobank Team, Daniel F. Levey, Joel Gelernter, Murray B. Stein, Ellen A. Tsai, Hailiang Huang, Christopher F. Chabris, Todd Lencz, Heiko Runz, Chia-Yen Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Nearly two hundred common-variant depression risk loci have been identified by genome-wide association studies (GWAS). However, the impact of rare coding variants on depression remains poorly understood. Here, we present whole-exome sequenci
Externí odkaz:
https://doaj.org/article/1855eca93fd445689cfb3f9e92f93eee
Autor:
Yunfeng Huang, Dora Bodnar, Chia-Yen Chen, Gabriela Sanchez-Andrade, Mark Sanderson, Biogen Biobank Team, Jun Shi, Katherine G. Meilleur, Matthew E. Hurles, Sebastian S. Gerety, Ellen A. Tsai, Heiko Runz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Abstract Muscle strength is highly heritable and predictive for multiple adverse health outcomes including mortality. Here, we present a rare protein-coding variant association study in 340,319 individuals for hand grip strength, a proxy measure of m
Externí odkaz:
https://doaj.org/article/de6b6e551a394c89b17455966b598956
Autor:
Chen-Yang Su, Sirui Zhou, Edgar Gonzalez-Kozlova, Guillaume Butler-Laporte, Elsa Brunet-Ratnasingham, Tomoko Nakanishi, Wonseok Jeon, David R. Morrison, Laetitia Laurent, Jonathan Afilalo, Marc Afilalo, Danielle Henry, Yiheng Chen, Julia Carrasco-Zanini, Yossi Farjoun, Maik Pietzner, Nofar Kimchi, Zaman Afrasiabi, Nardin Rezk, Meriem Bouab, Louis Petitjean, Charlotte Guzman, Xiaoqing Xue, Chris Tselios, Branka Vulesevic, Olumide Adeleye, Tala Abdullah, Noor Almamlouk, Yara Moussa, Chantal DeLuca, Naomi Duggan, Erwin Schurr, Nathalie Brassard, Madeleine Durand, Diane Marie Del Valle, Ryan Thompson, Mario A. Cedillo, Eric Schadt, Kai Nie, Nicole W. Simons, Konstantinos Mouskas, Nicolas Zaki, Manishkumar Patel, Hui Xie, Jocelyn Harris, Robert Marvin, Esther Cheng, Kevin Tuballes, Kimberly Argueta, Ieisha Scott, The Mount Sinai COVID-19 Biobank Team, Celia M. T. Greenwood, Clare Paterson, Michael A. Hinterberg, Claudia Langenberg, Vincenzo Forgetta, Joelle Pineau, Vincent Mooser, Thomas Marron, Noam D. Beckmann, Seunghee Kim-schulze, Alexander W. Charney, Sacha Gnjatic, Daniel E. Kaufmann, Miriam Merad, J. Brent Richards
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Predicting COVID-19 severity is difficult, and the biological pathways involved are not fully understood. To approach this problem, we measured 4701 circulating human protein abundances in two independent cohorts totaling 986 individuals. We
Externí odkaz:
https://doaj.org/article/01337ffce78741589c060c556f78383f
Akademický článek
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Autor:
Benjamin B. Sun, Stephanie J. Loomis, Fabrizio Pizzagalli, Natalia Shatokhina, Jodie N. Painter, Christopher N. Foley, Biogen Biobank Team, Megan E. Jensen, Donald G. McLaren, Sai Spandana Chintapalli, Alyssa H. Zhu, Daniel Dixon, Tasfiya Islam, Iyad Ba Gari, Heiko Runz, Sarah E. Medland, Paul M. Thompson, Neda Jahanshad, Christopher D. Whelan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Genetic associations with particular patterns of brain folding may provide insight into brain development and function. Here, the authors identify and replicate 388 genetic associations with brain sulcal morphology across 40,169 UK Biobank MRI scans,
Externí odkaz:
https://doaj.org/article/6a31732e43d94e97bac89d4842fe34f4
Autor:
Weiguang Mao, Clare M Miller, Venugopalan D Nair, Yongchao Ge, Mary Anne S Amper, Antonio Cappuccio, Mary‐Catherine George, Carl W Goforth, Kristy Guevara, Nada Marjanovic, German Nudelman, Hanna Pincas, Irene Ramos, Rachel S G Sealfon, Alessandra Soares‐Schanoski, Sindhu Vangeti, Mital Vasoya, Dawn L Weir, Elena Zaslavsky, Biobank Team, Seunghee Kim‐Schulze, Sacha Gnjatic, Miriam Merad, Andrew G Letizia, Olga G Troyanskaya, Stuart C Sealfon, Maria Chikina
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 5, Pp n/a-n/a (2023)
Abstract DNA methylation comprises a cumulative record of lifetime exposures superimposed on genetically determined markers. Little is known about methylation dynamics in humans following an acute perturbation, such as infection. We characterized the
Externí odkaz:
https://doaj.org/article/4218baf29182454bb07788f37ce0f8e4
Autor:
Noam D. Beckmann, Phillip H. Comella, Esther Cheng, Lauren Lepow, Aviva G. Beckmann, Scott R. Tyler, Konstantinos Mouskas, Nicole W. Simons, Gabriel E. Hoffman, Nancy J. Francoeur, Diane Marie Del Valle, Gurpawan Kang, Anh Do, Emily Moya, Lillian Wilkins, Jessica Le Berichel, Christie Chang, Robert Marvin, Sharlene Calorossi, Alona Lansky, Laura Walker, Nancy Yi, Alex Yu, Jonathan Chung, Matthew Hartnett, Melody Eaton, Sandra Hatem, Hajra Jamal, Alara Akyatan, Alexandra Tabachnikova, Lora E. Liharska, Liam Cotter, Brian Fennessy, Akhil Vaid, Guillermo Barturen, Hardik Shah, Ying-chih Wang, Shwetha Hara Sridhar, Juan Soto, Swaroop Bose, Kent Madrid, Ethan Ellis, Elyze Merzier, Konstantinos Vlachos, Nataly Fishman, Manying Tin, Melissa Smith, Hui Xie, Manishkumar Patel, Kai Nie, Kimberly Argueta, Jocelyn Harris, Neha Karekar, Craig Batchelor, Jose Lacunza, Mahlet Yishak, Kevin Tuballes, Ieisha Scott, Arvind Kumar, Suraj Jaladanki, Charuta Agashe, Ryan Thompson, Evan Clark, Bojan Losic, Lauren Peters, The Mount Sinai COVID-19 Biobank Team, Panagiotis Roussos, Jun Zhu, Wenhui Wang, Andrew Kasarskis, Benjamin S. Glicksberg, Girish Nadkarni, Dusan Bogunovic, Cordelia Elaiho, Sandeep Gangadharan, George Ofori-Amanfo, Kasey Alesso-Carra, Kenan Onel, Karen M. Wilson, Carmen Argmann, Supinda Bunyavanich, Marta E. Alarcón-Riquelme, Thomas U. Marron, Adeeb Rahman, Seunghee Kim-Schulze, Sacha Gnjatic, Bruce D. Gelb, Miriam Merad, Robert Sebra, Eric E. Schadt, Alexander W. Charney
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Multisystem inflammatory syndrome in children (MIS-C) onsets in COVID-19 patients with manifestations similar to Kawasaki disease (KD). Here the author probe the peripheral blood transcriptome of MIS-C patients to find signatures related to natural k
Externí odkaz:
https://doaj.org/article/7233a40d610f443eac2e6011b12c9368
Autor:
Tian, Ruoyu, Ge, Tian, Kweon, Hyeokmoon, Rocha, Daniel B., Lam, Max, Liu, Jimmy Z., Singh, Kritika, Biogen Biobank Team, Levey, Daniel F., Gelernter, Joel, Stein, Murray B., Tsai, Ellen A., Huang, Hailiang, Chabris, Christopher F., Lencz, Todd, Runz, Heiko, Chen, Chia-Yen
Publikováno v:
Nature Communications; 2/26/2024, p1-12, 12p
Autor:
Hillary RF; Optima Partners, Edinburgh, EH2 4HQ, UK.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Translational Sciences, Research and Development, Biogen Inc., Cambridge, MA, USA., Gadd DA; Optima Partners, Edinburgh, EH2 4HQ, UK.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Translational Sciences, Research and Development, Biogen Inc., Cambridge, MA, USA., Kuncheva Z; Optima Partners, Edinburgh, EH2 4HQ, UK.; Translational Sciences, Research and Development, Biogen Inc., Cambridge, MA, USA.; Bayes Centre, The University of Edinburgh, Edinburgh, EH8 9BT, UK., Mangelis T; Optima Partners, Edinburgh, EH2 4HQ, UK.; Translational Sciences, Research and Development, Biogen Inc., Cambridge, MA, USA.; Bayes Centre, The University of Edinburgh, Edinburgh, EH8 9BT, UK., Lin T; Translational Sciences, Research and Development, Biogen Inc., Cambridge, MA, USA., Ferber K; Translational Sciences, Research and Development, Biogen Inc., Cambridge, MA, USA., McLaughlin H; Translational Sciences, Research and Development, Biogen Inc., Cambridge, MA, USA., Runz H; Translational Sciences, Research and Development, Biogen Inc., Cambridge, MA, USA., Marioni RE; Optima Partners, Edinburgh, EH2 4HQ, UK. riccardo.marioni@ed.ac.uk.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK. riccardo.marioni@ed.ac.uk.; Translational Sciences, Research and Development, Biogen Inc., Cambridge, MA, USA. riccardo.marioni@ed.ac.uk., Foley CN; Optima Partners, Edinburgh, EH2 4HQ, UK. chris.foley@optimapartners.co.uk.; Translational Sciences, Research and Development, Biogen Inc., Cambridge, MA, USA. chris.foley@optimapartners.co.uk.; Bayes Centre, The University of Edinburgh, Edinburgh, EH8 9BT, UK. chris.foley@optimapartners.co.uk., Sun BB; Translational Sciences, Research and Development, Biogen Inc., Cambridge, MA, USA. bbsun92@outlook.com.; Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK. bbsun92@outlook.com.
Publikováno v:
Nature communications [Nat Commun] 2024 Aug 26; Vol. 15 (1), pp. 7346. Date of Electronic Publication: 2024 Aug 26.