Global Biobank Meta-analysis Initiative: Powering genetic discovery across human disease

Autor: Zhou, Wei, Kanai, Masahiro, Wu, Kuan-Han H, Rasheed, Humaira, Tsuo, Kristin, Hirbo, Jibril B, Wang, Ying, Bhattacharya, Arjun, Zhao, Huiling, Namba, Shinichi, Surakka, Ida, Wolford, Brooke N, Lo Faro, Valeria, Lopera-Maya, Esteban A, Läll, Kristi, Favé, Marie-Julie, Partanen, Juulia J, Chapman, Sinéad B, Karjalainen, Juha, Kurki, Mitja, Maasha, Mutaamba, Brumpton, Ben M, Chavan, Sameer, Chen, Tzu-Ting, Daya, Michelle, Ding, Yi, Feng, Yen-Chen A, Guare, Lindsay A, Gignoux, Christopher R, Graham, Sarah E, Hornsby, Whitney E, Ingold, Nathan, Ismail, Said I, Johnson, Ruth, Laisk, Triin, Lin, Kuang, Lv, Jun, Millwood, Iona Y, Moreno-Grau, Sonia, Nam, Kisung, Palta, Priit, Pandit, Anita, Preuss, Michael H, Saad, Chadi, Setia-Verma, Shefali, Thorsteinsdottir, Unnur, Uzunovic, Jasmina, Verma, Anurag, Zawistowski, Matthew, Zhong, Xue, Afifi, Nahla, Al-Dabhani, Kawthar M, Al Thani, Asma, Bradford, Yuki, Campbell, Archie, Crooks, Kristy, de Bock, Geertruida H, Damrauer, Scott M, Douville, Nicholas J, Finer, Sarah, Fritsche, Lars G, Fthenou, Eleni, Gonzalez-Arroyo, Gilberto, Griffiths, Christopher J, Guo, Yu, Hunt, Karen A, Ioannidis, Alexander, Jansonius, Nomdo M, Konuma, Takahiro, Lee, Ming Ta Michael, Lopez-Pineda, Arturo, Matsuda, Yuta, Marioni, Riccardo E, Moatamed, Babak, Nava-Aguilar, Marco A, Numakura, Kensuke, Patil, Snehal, Rafaels, Nicholas, Richmond, Anne, Rojas-Muñoz, Agustin, Shortt, Jonathan A, Straub, Peter, Tao, Ran, Vanderwerff, Brett, Vernekar, Manvi, Veturi, Yogasudha, Barnes, Kathleen C, Boezen, Marike, Chen, Zhengming, Chen, Chia-Yen, Cho, Judy, Smith, George Davey, Finucane, Hilary K, Franke, Lude, Gamazon, Eric R, Ganna, Andrea, Gaunt, Tom R, Ge, Tian, Huang, Hailiang, Huffman, Jennifer

Publikováno v: Cell genomics, vol 2, iss 10

Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic loci across a range of human diseases and traits. However, most biobanks are primarily composed of individuals of European ancestry. We introduce the Global Bioban

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::e6577d273afa470b981a31cc49417dce
https://escholarship.org/uc/item/5d40m2b7

Multi-omic analysis elucidates the genetic basis of hydrocephalus

Autor: Eric R. Gamazon, Andrew T. Hale, Lisa Bastarache, Diego M. Morales, David D. Limbrick, John C. Wellons

Publikováno v: Cell Reports, Vol 35, Iss 5, Pp 109085-(2021)
Cell reports

SUMMARY We conducted PrediXcan analysis of hydrocephalus risk in ten neurological tissues and whole blood. Decreased expression of MAEL in the brain was significantly associated (Bonferroni-adjusted p < 0.05) with hydrocephalus. PrediXcan analysis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdedbf51cedeb64475680043d232ad7
http://www.sciencedirect.com/science/article/pii/S2211124721004186

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Phenotype-Driven Plasma Biobanking Strategies and Methods

Autor: Rebecca N Jerome, Quinn S. Wells, Nancy J. Brown, Xiaoming Wang, Raymond L. Mernaugh, Miguel Herrera, Dan M. Roden, Lindsay J. Couch, Jill M. Pulley, Cara Sutcliffe, Candace D. McNaughton, Erica Bowton, Sara L. Van Driest, William E. Alborn, Daniel C. Liebler, Robbert J.C. Slebos, Sarah P. Collier

Publikováno v: Journal of Personalized Medicine
Volume 5
Issue 2
Pages 140-152
Journal of Personalized Medicine, Vol 5, Iss 2, Pp 140-152 (2015)

Biobank development and integration with clinical data from electronic medical record (EMR) databases have enabled recent strides in genomic research and personalized medicine. BioVU, Vanderbilt's DNA biorepository linked to de-identified clinical EM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f887072c61482b895f9daaa60c993a90

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.