Zobrazeno 1 - 10
of 821
pro vyhledávání: '"BioID"'
Autor:
Hasam Madarati, Veronica DeYoung, Kanwal Singh, Taylor Sparring, Andrew C. Kwong, James C. Fredenburgh, Cherie Teney, Marlys L. Koschinsky, Michael B. Boffa, Jeffrey I. Weitz, Colin A. Kretz
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract ADAMTS13, a disintegrin and metalloprotease with a thrombospondin type 1 motif, member 13, regulates the length of Von Willebrand factor (VWF) multimers and their platelet-binding activity. ADAMTS13 is constitutively secreted as an active pr
Externí odkaz:
https://doaj.org/article/e6c1de69cded4b81ba05feac596653ea
Publikováno v:
eLife, Vol 13 (2024)
Immunofluorescence localises proteins via fluorophore-labelled antibodies. However, some proteins evade detection due to antibody-accessibility issues or because they are naturally low abundant or antigen density is reduced by the imaging method. Her
Externí odkaz:
https://doaj.org/article/7935edb07619427ea4286357d94e9d4a
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Synapses play a pivotal role in forming neural circuits, with critical implications for brain functions such as learning, memory, and emotions. Several advances in synaptic research have demonstrated the diversity of synaptic structure and function,
Externí odkaz:
https://doaj.org/article/966d12f508c748cbaa72f250f9834260
Autor:
Marie C. Wesener, Sofia M. E. Weiler, Michaela Bissinger, Tobias F. Klessinger, Fabian Rose, Sabine Merker, Marcin Luzarowski, Thomas Ruppert, Barbara Helm, Ursula Klingmüller, Peter Schirmacher, Kai Breuhahn
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8549 (2024)
The Hippo pathway transducers yes-associated protein (YAP) and WW-domain containing transcription regulator 1 (WWTR1/TAZ) are key regulators of liver tumorigenesis, promoting tumor formation and progression. Although the first inhibitors are in clini
Externí odkaz:
https://doaj.org/article/bee2e341f10846118590b9e85a14fbfa
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Protein‒protein, protein‒RNA, and protein‒DNA interaction networks form the basis of cellular regulation and signal transduction, making it crucial to explore these interaction networks to understand complex biological processes. Tradi
Externí odkaz:
https://doaj.org/article/799bf1f5074c4df399069d6cf42c7240
Autor:
Sarah Fox, Antoine Gaudreau-LaPierre, Ryan Reshke, Irina Podinic, Derrick J. Gibbings, Laura Trinkle-Mulcahy, John W. Copeland
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5686 (2024)
Formin Homology Proteins (Formins) are a highly conserved family of cytoskeletal regulatory proteins that participate in a diverse range of cellular processes. FMNL2 is a member of the Diaphanous-Related Formin sub-group, and previous reports suggest
Externí odkaz:
https://doaj.org/article/451ea99e8678477aa936a8257405b5da
Autor:
Juha Saarikettu, Saara Lehmusvaara, Marko Pesu, Ilkka Junttila, Juha Partanen, Petra Sipilä, Matti Poutanen, Jie Yang, Teemu Haikarainen, Olli Silvennoinen
Publikováno v:
FASEB BioAdvances, Vol 5, Iss 5, Pp 183-198 (2023)
Abstract Snd1 is an evolutionarily conserved RNA‐binding protein implicated in several regulatory processes in gene expression including activation of transcription, mRNA splicing, and microRNA decay. Here, we have investigated the outcome of Snd1
Externí odkaz:
https://doaj.org/article/16f18b224da54a86aa8f9e82d02f1857
Autor:
Yanfei Zhang, Jiayu Jin, Heming Wu, Jingwen Huang, Shuting Ye, Jinhua Qiu, Gaoliang Ouyang, Tiantian Wu, Fan Liu, Yingfu Liu
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 15, Iss 6, Pp 1475-1504 (2023)
Background & Aims: The matricellular protein periostin plays a critical role in liver inflammation, fibrosis, and even carcinoma. Here, the biological function of periostin in alcohol-related liver disease (ALD) was investigated. Methods: We used wil
Externí odkaz:
https://doaj.org/article/3cd17ea61a824ed587045428aea057ac
Autor:
Camila de Castro Ferezin, Terry C. C. Lim Kam Sian, Yunjian Wu, Xiuquan Ma, Anderly C. Chüeh, Cheng Huang, Ralf B. Schittenhelm, Jörg Kobarg, Roger J. Daly
Publikováno v:
Cell Communication and Signaling, Vol 20, Iss 1, Pp 1-15 (2022)
Abstract Specific members of the Nima-Related Kinase (NEK) family have been linked to cancer development and progression, and a role for NEK5, one of the least studied members, in breast cancer has recently been proposed. However, while NEK5 is known
Externí odkaz:
https://doaj.org/article/c378bb59b2cf411a9627920228787a5e
Autor:
Berta Duran-Arqué, Manuel Cañete, Chiara Lara Castellazzi, Anna Bartomeu, Anna Ferrer-Caelles, Oscar Reina, Adrià Caballé, Marina Gay, Gianluca Arauz-Garofalo, Eulalia Belloc, Raúl Mendez
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-27 (2022)
Abstract Background Vertebrate CPEB proteins bind mRNAs at cytoplasmic polyadenylation elements (CPEs) in their 3′ UTRs, leading to cytoplasmic changes in their poly(A) tail lengths; this can promote translational repression or activation of the mR
Externí odkaz:
https://doaj.org/article/f2d44e0e32c84e0b8bb39e127da46f6f