Exploring Porcine Gastric and Intestinal Fluids using Microscopic and Solubility Estimates:Impact of Placebo Self-Emulsifying Drug Delivery System Administration to Inform Bio-Predictive in vitro Tools

Autor: Laura J. Henze, Joseph P. O'Shea, Jacob Rune Jørgensen, Niklas J. Koehl, Harriet Bennett-Lenane, Anette Müllertz, Brendan T. Griffin

Publikováno v: Bennett-Lenane, H, Jørgensen, J R, Koehl, N J, Henze, L J, O'Shea, J P, Müllertz, A & Griffin, B T 2021, ' Exploring Porcine Gastric and Intestinal Fluids using Microscopic and Solubility Estimates : Impact of Placebo Self-Emulsifying Drug Delivery System Administration to Inform Bio-Predictive in vitro Tools ', European Journal of Pharmaceutical Sciences, vol. 161, 105778 . https://doi.org/10.1016/j.ejps.2021.105778

Validation and characterisation of in vitro and pre-clinical animal models to support bio-enabling formulation development is of paramount importance. In this work, post-mortem gastric and small intestinal fluids were collected in the fasted, fed sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4fb52694411d08daffa803bad79c3bc
https://curis.ku.dk/ws/files/263034089/1_s2.0_S0928098721000804_main.pdf

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Food for thought: formulating away the food effect - a PEARRL review

Autor: Joseph P. O'Shea, Caitriona M. O'Driscoll, Brendan T. Griffin, René Holm

Publikováno v: Journal of Pharmacy and Pharmacology

Objectives Co-ingestion of oral dosage forms with meals can cause substantial changes in bioavailability relative to the fasted state. Food-mediated effects on bioavailability can have significant consequences in drug development, regulatory and clin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21f64b7eb25eb0cf4a2955ed88913f36
https://hdl.handle.net/10468/7108

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