Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Binyuan, Sun"'
Autor:
Prasanthi Geda, Mark A. McCoy, Liping Yang, Chaomin Li, Armetta D. Hill, Xavier Fradera, Marianne L. Spatz, Matthew Ernst Voss, Carolyn Michele Cammarano, Pierre Daublain, Xiao Wang, Christopher F. Thompson, B. Wesley Trotter, C. Gary Marshall, Michael H. Reutershan, Peter Goldenblatt, Latha G. Nair, Manami Shizuka, Tammie C. Yeh, John G. Cryan, Isabelle Dussault, Michelle Martinez, Mingmei Cai, Raymond A. Kemper, Binyuan Sun, Michelle R. Machacek, Dietrich Steinhuebel, Giovanna Scapin, Michael D. Altman, Stephane L. Bogen, Matthew Christopher, Dapeng Chen, Victoria Kutilek, Weidong Pan
Publikováno v:
Journal of Medicinal Chemistry. 64:16213-16241
Identification of low-dose, low-molecular-weight, drug-like inhibitors of protein-protein interactions (PPIs) is a challenging area of research. Despite the challenges, the therapeutic potential of PPI inhibition has driven significant efforts toward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9f003ba884dc7f950fc132b2a33cadf
https://doi.org/10.1021/acs.jmedchem.1c01524
https://doi.org/10.1021/acs.jmedchem.1c01524
Autor:
Michael H, Reutershan, Michelle R, Machacek, Michael D, Altman, Stephane, Bogen, Mingmei, Cai, Carolyn, Cammarano, Dapeng, Chen, Matthew, Christopher, John, Cryan, Pierre, Daublain, Xavier, Fradera, Prasanthi, Geda, Peter, Goldenblatt, Armetta D, Hill, Raymond A, Kemper, Victoria, Kutilek, Chaomin, Li, Michelle, Martinez, Mark, McCoy, Latha, Nair, Weidong, Pan, Christopher F, Thompson, Giovanna, Scapin, Manami, Shizuka, Marianne L, Spatz, Dietrich, Steinhuebel, Binyuan, Sun, Matthew E, Voss, Xiao, Wang, Liping, Yang, Tammie C, Yeh, Isabelle, Dussault, C Gary, Marshall, B Wesley, Trotter
Publikováno v:
Journal of medicinal chemistry. 64(21)
Identification of low-dose, low-molecular-weight, drug-like inhibitors of protein-protein interactions (PPIs) is a challenging area of research. Despite the challenges, the therapeutic potential of PPI inhibition has driven significant efforts toward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c70be0458a74b9595c42b9269bd0b63
https://pubmed.ncbi.nlm.nih.gov/34714078
https://pubmed.ncbi.nlm.nih.gov/34714078
Publikováno v:
Tetrahedron Letters. 54:6373-6377
Acid-mediated cyclizations of SEM-protected heterocyclic anilines and adjacent hydroxyls or enol ethers during SEM deprotection are reported. Strategies to suppress these side reactions and their potential synthetic utilities are also described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0720e553ad1530d87c8d73deca76c78d
https://doi.org/10.1016/j.tetlet.2013.09.059
https://doi.org/10.1016/j.tetlet.2013.09.059
Autor:
Sheila M. Galloway, Binyuan Sun, Nancy Kelly, John W. Butcher, Grace H. C. Woo, Kerrie Spencer, J. Michael Ellis, Ryan D. Otte, Ekundayo Osimboni, Alan S. Bass, Sandra Lee, J. Richard Miller, Chiming Yang, Erica Leccese, Andrew M. Haidle, Alan B. Northrup, Lily Y. Moy, James P. Jewell, Alan Byford, Hani Houshyar, Gwendolyn J. Ward, Anthony Donofrio, Matthew L. Maddess, Michael D. Altman, M. Vijay Reddy, Stella H. Vincent
Publikováno v:
Journal of medicinal chemistry. 58(4)
Development of a series of highly kinome-selective spleen tyrosine kinase (Syk) inhibitors with favorable druglike properties is described. Early leads were discovered through X-ray crystallographic analysis, and a systematic survey of cores within a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::040b080e82842dc9548a30636c5cf5d6
https://pubmed.ncbi.nlm.nih.gov/25625541
https://pubmed.ncbi.nlm.nih.gov/25625541
Publikováno v:
Proceedings of the National Academy of Sciences. 100:5658-5663
Bacterial transglycosylases are enzymes that couple the disaccharide subunits of peptidoglycan to form long carbohydrate chains. These enzymes are the target of the pentasaccharide antibiotic moenomycin as well as the proposed target of certain glyco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b891cd79cfa599961ec33087fc6a3dc3
https://doi.org/10.1073/pnas.0931492100
https://doi.org/10.1073/pnas.0931492100
Autor:
Binyuan Sun, John V. LaTour, Daniel Kahne, Steven D Dong, Ulrike S. Eggert, Zhong Chen, Simon J. Shaw
Publikováno v:
Tetrahedron. 58:6585-6594
We have prepared several sets of glycopeptide analogues in order to probe the molecular basis for the activity of derivatives that overcome vanA resistance. The results described in this paper provide compelling evidence that good vanA activity is du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ced795e8fd39516e2a81287fb690029
https://doi.org/10.1016/s0040-4020(02)00743-3
https://doi.org/10.1016/s0040-4020(02)00743-3
Publikováno v:
ChemInform. 45
Substrates (I) undergo unexpected acid mediated cyclization involving the Sem-protecting amino group and a neighboring enol ether moiety to produce tricyclic heterocycles (II).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::560efba1e82f33f7e1d9013c7462c855
https://doi.org/10.1002/chin.201413177
https://doi.org/10.1002/chin.201413177
Autor:
Binyuan Sun, Paul A. Mann, Peter Orth, Gerald W. Shipps, Li Xiao, Aileen Soriano, Kyle Ann Soucy, Todd A. Black, Noriyuki Kawahata, Zhiwei Yang, Cliff C. Cheng
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(23)
The biotin carboxylase (AccC) is part of the multi-component bacterial acetyl coenzyme-A carboxylase (ACCase) and is essential for pathogen survival. We describe herein the affinity optimization of an initial hit to give 2-(2-chlorobenzylamino)-1-(cy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0525b2d41dfa39e32e197f38c79d66
https://pubmed.ncbi.nlm.nih.gov/19875284
https://pubmed.ncbi.nlm.nih.gov/19875284
Publikováno v:
Journal of the American Chemical Society. 128(43)
Moenomycin A is the only known natural product that inhibits peptidoglycan biosynthesis by binding the bacterial transglycosylases. We describe a degradation/reconstruction route to manipulate the reducing end of moenomycin A. A comparison of the bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5616cd36f192df40e7c8335f577b552e
https://pubmed.ncbi.nlm.nih.gov/17061868
https://pubmed.ncbi.nlm.nih.gov/17061868
Autor:
Gianbattista Panzone, Markus Oberthür, Catherine Leimkuhler, Dianah Barrett, Daniel Kahne, Brian Falcone, Suzanne Walker, Lan Chen, Binyuan Sun, Stefano Donadio
Publikováno v:
Journal of the American Chemical Society. 127:3250-3251
The glycopeptide antibiotics prevent maturation of the bacterial cell wall by binding to the terminal d-alanyl-d-alanine moiety of peptidoglycan precursors, thereby inhibiting the enzymes involved in the final stages of peptidoglycan synthesis. Howev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0866545f2b731cc4d75c33d24c90d627
https://doi.org/10.1021/ja043849e
https://doi.org/10.1021/ja043849e